INT54515

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Context Info
Confidence 0.12
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.33
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
neuronal 2
grey matter 2
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 3 99.84 Very High Very High Very High
Analgesic 8 99.56 Very High Very High Very High
ischemia 173 99.52 Very High Very High Very High
IPN 1 98.20 Very High Very High Very High
Periaqueductal grey 1 97.72 Very High Very High Very High
Intracerebroventricular 5 97.62 Very High Very High Very High
mu opioid receptor 5 96.52 Very High Very High Very High
Pain 6 93.76 High High
sodium channel 7 89.08 High High
Hippocampus 41 86.44 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 110 99.52 Very High Very High Very High
Death 49 99.24 Very High Very High Very High
Inflammatory Pain 1 98.20 Very High Very High Very High
Urological Neuroanatomy 2 97.72 Very High Very High Very High
Pain 3 93.76 High High
Hypothermia 14 93.08 High High
Stress 67 71.76 Quite High
Apoptosis 50 70.40 Quite High
Cv Unclassified Under Development 61 66.40 Quite High
INFLAMMATION 25 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analgesic response due to CNF1 requires both the sustained activation of the Rac GTPase, with consequent cerebral actin cytoskeleton remodeling, and the up-regulation of the mu-opioid receptors (MORs), the most important receptors controlling pain perception.
Positive_regulation (requires) of Positive_regulation (activation) of Rac GTPase associated with pain, analgesic and mu opioid receptor
1) Confidence 0.12 Published 2009 Journal Pain Section Abstract Doc Link 19608345 Disease Relevance 0.25 Pain Relevance 0.85
In fact, many shared genes are readily identified as being immune related, such as immunity related GTPase, very large Ifn inducible GTPase, IL1?
Positive_regulation (inducible) of Positive_regulation (large) of GTPase
2) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.42 Pain Relevance 0.17
Intracerebroventricular (i.c.v.) administration to mice of IgGs raised against alpha subunits of Gi2 or Gx/z transducer proteins lessened the activation of low Km GTPase induced by morphine, DAMGO and DADLE in P2 membranes from mouse periaqueductal grey matter (PAG).
Positive_regulation (induced) of Positive_regulation (activation) of Km GTPase in grey matter associated with periaqueductal grey, urological neuroanatomy, intracerebroventricular and morphine
3) Confidence 0.06 Published 1994 Journal Life Sci. Section Abstract Doc Link 7915394 Disease Relevance 0.19 Pain Relevance 0.80
Rac GTPase activation is critical for enhanced NADPH oxidase activity and O2?
Positive_regulation (critical) of Positive_regulation (activation) of Rac GTPase
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.50 Pain Relevance 0.25
NSC23766 treatment markedly attenuated hippocampal CA1 neuronal death following GCI, suggesting a critical role for Rac GTPase activation in delayed neuronal cell degeneration and death in the hippocampal CA1 region following GCI.


Positive_regulation (role) of Positive_regulation (activation) of Rac GTPase in neuronal associated with ischemia and death
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.83 Pain Relevance 0.27
It has been reported that C-terminal GTPase effector (GED) domains are important for stimulation of GTPase activity, formation and stability of higher order complexes and efficient mitochondrial division [47].
Positive_regulation (important) of Positive_regulation (stimulation) of GTPase
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677674 Disease Relevance 0.13 Pain Relevance 0

General Comments

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