INT5452

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 3
Speculated 6
Reported most in Abstract
Documents 56
Total Number 63
Disease Relevance 15.32
Pain Relevance 12.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
cervix 10
AtT-20 5
plasma 4
neurons 4
pituitary 4
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 94 100.00 Very High Very High Very High
narcan 40 100.00 Very High Very High Very High
dexamethasone 19 100.00 Very High Very High Very High
Opioid 2 99.98 Very High Very High Very High
Inflammation 98 99.96 Very High Very High Very High
Dopamine 3 99.76 Very High Very High Very High
monoamine 28 99.58 Very High Very High Very High
noradrenaline 8 99.36 Very High Very High Very High
Enkephalin 14 99.30 Very High Very High Very High
fluoxetine 21 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 321 100.00 Very High Very High Very High
INFLAMMATION 95 99.96 Very High Very High Very High
Depressive Disorder 49 99.84 Very High Very High Very High
Schizophrenia 332 99.68 Very High Very High Very High
Affective Disorder 74 99.64 Very High Very High Very High
Depression 135 98.32 Very High Very High Very High
Hypoglycemia 4 97.92 Very High Very High Very High
Endometriosis 224 97.74 Very High Very High Very High
Anxiety Disorder 18 97.24 Very High Very High Very High
Post-traumatic Stress Disorder 13 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.
Regulation (regulation) of Corticotropin releasing factor in ileum associated with stress
1) Confidence 0.62 Published 2009 Journal J. Physiol. Pharmacol. Section Title Doc Link 20388944 Disease Relevance 0.46 Pain Relevance 0.06
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Regulation (effect) of CRH gene associated with antidepressant
2) Confidence 0.62 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
Forskolin (an activator of adenylate cyclase), but not phorbol 12-myristate 13-acetate (an activator of protein kinase C), ca. 3-fold increased reporter gene activity, which confirms the critical role of the cAMP-responsive element in regulation of the CRH gene.
Regulation (regulation) of CRH gene associated with kinase c
3) Confidence 0.62 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.30
Effect of antidepressant drugs on the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells.
Regulation (Effect) of corticotropin-releasing-hormone gene promoter associated with antidepressant
4) Confidence 0.62 Published 2002 Journal Pol J Pharmacol Section Title Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.28
The regulation of CRH gene promoter activity is similar in Neuro-2A cells, both intact and differentiated, and in AtT-20 cell line, and cAMP/PKA-dependent pathway plays an important role in the stimulation of CRH gene.
Regulation (regulation) of CRH gene in AtT-20
5) Confidence 0.62 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.14 Pain Relevance 0.34
Regulation of the human corticotropin-releasing-hormone gene promoter activity by antidepressant drugs in Neuro-2A and AtT-20 cells.
Regulation (Regulation) of corticotropin-releasing-hormone gene promoter in AtT-20 associated with antidepressant
6) Confidence 0.62 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 14735130 Disease Relevance 0.19 Pain Relevance 0.31
In order to find out whether antidepressants directly affect CRH gene promoter activity, we studied their effect on undifferentiated and differentiated Neuro-2A cells, and for comparison the effect of the selected antidepressants on AtT-20 cells was also determined.
Spec (whether) Regulation (affect) of CRH gene in AtT-20 associated with antidepressant
7) Confidence 0.62 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.17 Pain Relevance 0.25
In this study, the biochemical and molecular mechanisms involved in transcriptional regulation of the corticotropin-releasing hormone (CRH) gene by depolarization were investigated.
Regulation (regulation) of CRH
8) Confidence 0.61 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.04
In this study, the biochemical and molecular mechanisms involved in transcriptional regulation of the corticotropin-releasing hormone (CRH) gene by depolarization were investigated.
Regulation (regulation) of corticotropin-releasing hormone
9) Confidence 0.61 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.04
Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels.
Regulation (alters) of CRF associated with dopamine, noradrenaline, serotonin and monoamine
10) Confidence 0.60 Published 1996 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 8917909 Disease Relevance 0.07 Pain Relevance 0.56
The detection of substantial expression of the CRH and its receptor proteins, as well as receptor mRNA in the cervix suggests that the cervix may be a target for CRH action.
Regulation (target) of CRH in cervix
11) Confidence 0.59 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.07 Pain Relevance 0.03
In contrast, bilateral truncal vagotomy did not affect the gastric inhibitory action of CRF.
Neg (not) Regulation (affect) of CRF
12) Confidence 0.50 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3544874 Disease Relevance 0.20 Pain Relevance 0.29
In addition, their function is dependent upon other intracellular signals via communication between signalling cascades, suggesting potential multiple roles of CRH and other CRH-like peptides during pregnancy and labor.
Regulation (roles) of CRH
13) Confidence 0.45 Published 2007 Journal Front. Biosci. Section Abstract Doc Link 17127317 Disease Relevance 0.14 Pain Relevance 0.17
Studies utilizing the DST did not require a control group since the rate of non-suppression of cortisol during this test in the general population is well documentedStudies measuring the response of the HPA axis to psychological stress used a psychological stressor with the ability to produce a measurable stress response as assessed by the cortisol, ACTH or CRH response in a non-psychiatric control group.
Regulation (response) of CRH associated with stress
14) Confidence 0.45 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.62 Pain Relevance 0.03
On the other hand, the serum levels of Met-enk, epinephrin, CRF, cortisol and CD57 were not significantly different between the two groups.
Neg (not) Regulation (different) of CRF
15) Confidence 0.44 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11072598 Disease Relevance 0.06 Pain Relevance 0
We studied the responses of plasma CRH, ACTH, cortisol, norepinephrine, epinephrine, and renin activity in 11 patients undergoing parathyroid or thyroid surgery after identical preoperative sedation and during isoflurane (Forane) anesthesia.
Regulation (responses) of CRH in parathyroid associated with anesthesia, isoflurane and sleep disorders
16) Confidence 0.44 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3031124 Disease Relevance 0.17 Pain Relevance 0.14
These two examples illustrate the potential therapeutic significance of the CRH in regulating inflammatory phenomena in an ad hoc approach without affecting the rest of the immune system.
Regulation (regulating) of CRH in immune system associated with inflammation
17) Confidence 0.44 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 15974983 Disease Relevance 1.27 Pain Relevance 0.52
Effects of corticotropin-releasing factor (CRF), tuftsin and dermorphin on behavior of squirrel monkeys maintained by different events.
Regulation (Effects) of CRF associated with narcan
18) Confidence 0.44 Published 1989 Journal Peptides Section Title Doc Link 2576126 Disease Relevance 0.35 Pain Relevance 0.24
Blood samples were collected for cortisol, beta-EP and CRH assay on most of these occasions and during labour.
Regulation (collected) of CRH in Blood
19) Confidence 0.44 Published 1990 Journal J Psychosom Res Section Abstract Doc Link 2138227 Disease Relevance 0.29 Pain Relevance 0.08
The exaggerated cortisol response to the dex/CRH test in mood disorder patients who do not report high levels of childhood emotional neglect suggests reduced GR mediated negative feedback in these patients.
Regulation (response) of CRH associated with affective disorder
20) Confidence 0.44 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.31 Pain Relevance 0

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