INT5453

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 11
Speculated 19
Reported most in Abstract
Documents 114
Total Number 133
Disease Relevance 20.56
Pain Relevance 56.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
pituitary 22
blood 8
melanocyte 8
plasma 6
hypothalamus 6
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 218 100.00 Very High Very High Very High
Opioid 158 100.00 Very High Very High Very High
Enkephalin 142 100.00 Very High Very High Very High
antagonist 108 100.00 Very High Very High Very High
agonist 101 100.00 Very High Very High Very High
Neuropeptide 66 100.00 Very High Very High Very High
Clonidine 65 100.00 Very High Very High Very High
gABA 65 100.00 Very High Very High Very High
opiate 64 100.00 Very High Very High Very High
Morphine 45 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 26 100.00 Very High Very High Very High
Disease 111 99.98 Very High Very High Very High
Pituitary Cancer 7 99.68 Very High Very High Very High
Eating Disorder 19 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 11 99.52 Very High Very High Very High
Stress 325 99.36 Very High Very High Very High
Hemorrhage 24 99.34 Very High Very High Very High
Anxiety Disorder 22 99.16 Very High Very High Very High
Diuresis 4 99.16 Very High Very High Very High
Schizophrenia 10 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of dexamethasone on exercise-induced adrenocorticotropin (ACTH) secretion and dental analgesia was studied in healthy human subjects.
Regulation (effect) of Localization (secretion) of ACTH associated with dexamethasone and analgesia
1) Confidence 0.62 Published 1990 Journal Brain Res. Section Abstract Doc Link 2168784 Disease Relevance 0.24 Pain Relevance 0.59
This study was carried out to investigate whether the regulation of beta-endorphin secretion may be different in different phenotypes of obesity.
Regulation (regulation) of Localization (secretion) of beta-endorphin associated with obesity
2) Confidence 0.62 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8242128 Disease Relevance 0.67 Pain Relevance 0.10
In the present paper the intracellular signalling pathways involved in regulation of the secretion of immunoreactive (ir) beta-endorphin by human peripheral blood mononuclear cells are described.
Regulation (regulation) of Localization (secretion) of beta-endorphin in blood
3) Confidence 0.62 Published 1991 Journal Endocrinology Section Abstract Doc Link 1824933 Disease Relevance 0 Pain Relevance 0.14
Adrenergic mechanisms play an important role in regulation of ACTH release.
Regulation (regulation) of Localization (release) of ACTH
4) Confidence 0.62 Published 1990 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2160341 Disease Relevance 0 Pain Relevance 0.58
We conclude that glucocorticoids and morphine agonists exert interactive inhibitory effects on ACTH release in humans, probably by virtue of their suppression of CRH release from the hypothalamus.
Regulation (effects) of Localization (release) of ACTH in hypothalamus associated with agonist and morphine
5) Confidence 0.62 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3036903 Disease Relevance 0 Pain Relevance 0.73
We aimed to investigate this hypothesis by measuring the effect of the highly specific serotonin re-uptake inhibitor fluoxetine (FX) on ACTH and cortisol release in the morning and in the afternoon in humans, both by itself and in combination with the opioid antagonist naloxone (Nal).
Regulation (effect) of Localization (release) of ACTH associated with antagonist, narcan, opioid, serotonin and fluoxetine
6) Confidence 0.62 Published 1997 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9171947 Disease Relevance 0.10 Pain Relevance 0.82
The aim of this study was to investigate the effect of the mu-opiate agonist, loperamide, and the opiate antagonist, naloxone, on ceruletide-induced ACTH secretion in man.
Spec (investigate) Regulation (effect) of Localization (secretion) of ACTH associated with antagonist, narcan, agonist and opiate
7) Confidence 0.62 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090278 Disease Relevance 0.08 Pain Relevance 0.55
Based on the lack of an effect of DT on the ACTH response to CRH, we postulate that DT may modulate the secretion of ACTH through suprapituitary mechanisms.
Regulation (modulate) of Localization (secretion) of ACTH
8) Confidence 0.62 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322422 Disease Relevance 0.34 Pain Relevance 0.23
[Exogenous effects on ACTH and cortisol secretion].
Regulation (effects) of Localization (secretion) of ACTH
9) Confidence 0.62 Published 1995 Journal Fortschr. Med. Section Title Doc Link 7883264 Disease Relevance 0.09 Pain Relevance 0.15
Effect of sodium valproate on naloxone-stimulated ACTH and cortisol release in humans.
Regulation (Effect) of Localization (release) of ACTH associated with narcan
10) Confidence 0.62 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.73
In conclusion, SV had no effect on naloxone-induced ACTH and cortisol release in normal humans at the dose and plasma drug concentrations studied.
Neg (no) Regulation (effect) of Localization (release) of ACTH in plasma associated with narcan
11) Confidence 0.62 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.48
However, recent evidence suggests that some of the sensory convergence and temporal plasticity within the system that controls ACTH release may exist at the brain-stem level.
Regulation (controls) of Localization (release) of ACTH in stem
12) Confidence 0.61 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981738 Disease Relevance 0 Pain Relevance 0.05
In conclusion, it was shown that the stimuli mentioned above directly affect ACTH secretion by the pituitary tumor cells.
Regulation (affect) of Localization (secretion) of ACTH in pituitary associated with pituitary cancer
13) Confidence 0.61 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6270182 Disease Relevance 0.33 Pain Relevance 0.51
The influence of the intrapallidal application of GABA-related compounds on the release of Met-enkephalin in the globus pallidus and the caudate nucleus in the two hemispheres was investigated in vivo in the cat.
Spec (investigated) Regulation (influence) of Localization (release) of Met-enkephalin in globus pallidus associated with gaba and enkephalin
14) Confidence 0.60 Published 1982 Journal Brain Res. Section Abstract Doc Link 7139278 Disease Relevance 0 Pain Relevance 0.45
These data indicate that the action of D is mediated through opioid receptors, and are consistent with the conclusion that 1) D, a new opioid peptide, increases PRA levels, perhaps via activation of the sympathetic nervous system, providing evidence that opioid peptides may exert an influence on renin secretion; and 2) D suppresses PC levels, perhaps by affecting ACTH secretion, corroborating previous observations that opioid peptides might affect the function of the pituitary-adrenocortical axis.
Regulation (affecting) of Localization (secretion) of ACTH in pituitary associated with opioid receptor and opioid
15) Confidence 0.60 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313731 Disease Relevance 0 Pain Relevance 0.60
The effects of cocaine on pulsatile secretion of adrenocorticotropic hormone (ACTH) in men were studied under controlled clinical research ward conditions.
Regulation (effects) of Localization (secretion) of adrenocorticotropic hormone associated with cocaine
16) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932162 Disease Relevance 0.08 Pain Relevance 0.29
The aim of our study in rats was to characterize the effects of general anesthesia without any surgery on HPA regulation of corticosterone and adrenocorticotropic hormone (ACTH) secretions.
Regulation (regulation) of Localization (secretions) of ACTH associated with anesthesia
17) Confidence 0.60 Published 2009 Journal Chronobiol. Int. Section Abstract Doc Link 19444750 Disease Relevance 0.09 Pain Relevance 0.58
Third, the effects of propofol anesthesia on corticosterone and ACTH secretion were studied in rats instrumented with intracarotid cannulation.
Regulation (effects) of Localization (secretion) of ACTH associated with anesthesia
18) Confidence 0.60 Published 2009 Journal Chronobiol. Int. Section Abstract Doc Link 19444750 Disease Relevance 0.06 Pain Relevance 0.72
Morphine had no effect on the spontaneous or ACTH-induced secretion of cortisol by interrenal tissue incubated in vitro.
Neg (no) Regulation (effect) of Localization (secretion) of ACTH in interrenal tissue associated with morphine
19) Confidence 0.60 Published 1987 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 2822527 Disease Relevance 0.10 Pain Relevance 1.04
The present study was undertaken in order to establish whether alterations in the endogenous opioid control of luteinizing hormone (LH) and ACTH/cortisol secretion occur in bulimic women with normal body weight and normal menstrual cycles.
Spec (whether) Regulation (control) of Localization (secretion) of ACTH in body associated with body weight, endogenous opioid and eating disorder
20) Confidence 0.60 Published 1990 Journal Psychoneuroendocrinology Section Abstract Doc Link 2101966 Disease Relevance 0.40 Pain Relevance 0.35

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