INT5454

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.79
First Reported 1985
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 124
Total Number 127
Disease Relevance 79.18
Pain Relevance 41.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
hypothalamus 11
plasma 9
pituitary 7
placenta 5
neurons 4
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 664 100.00 Very High Very High Very High
Inflammation 386 100.00 Very High Very High Very High
Catecholamine 80 100.00 Very High Very High Very High
Neuropeptide 74 100.00 Very High Very High Very High
Somatostatin 59 100.00 Very High Very High Very High
Opioid 57 100.00 Very High Very High Very High
Neurotransmitter 46 100.00 Very High Very High Very High
GABAergic 1 100.00 Very High Very High Very High
Pain 315 99.84 Very High Very High Very High
narcan 158 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 530 100.00 Very High Very High Very High
Heart Failure 498 100.00 Very High Very High Very High
Chronic Renal Failure 440 100.00 Very High Very High Very High
INFLAMMATION 415 100.00 Very High Very High Very High
Hyperaldosteronism 9 100.00 Very High Very High Very High
Carcinoid 2 100.00 Very High Very High Very High
Pheochromocytoma 29 99.96 Very High Very High Very High
Pain 382 99.84 Very High Very High Very High
Stress 928 99.82 Very High Very High Very High
Syndrome 101 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cushing's syndrome due to ectopic CRH secretion by adrenal pheochromocytoma accompanied by renal infarction.
Localization (secretion) of CRH associated with syndrome, infarction and pheochromocytoma
1) Confidence 0.79 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Title Doc Link 17039427 Disease Relevance 1.05 Pain Relevance 0.18
This was complicated by renal infarction, illustrating further the complexity of Cushing's syndrome in a patient with pheochromocytoma caused by CRH hypersecretion.
Localization (hypersecretion) of CRH associated with syndrome, infarction and pheochromocytoma
2) Confidence 0.79 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17039427 Disease Relevance 1.14 Pain Relevance 0.19
The release of corticotrophin-releasing factor (CRF) in the human has been shown to be under a direct inhibitory control derived from the locus coeruleus (LC).
Localization (release) of CRF in locus coeruleus associated with locus ceruleus
3) Confidence 0.79 Published 1988 Journal Int. J. Neurosci. Section Abstract Doc Link 3165969 Disease Relevance 0.37 Pain Relevance 0.41
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Localization (release) of CRF associated with reprotox - general 2 and stress
4) Confidence 0.78 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.10 Pain Relevance 0.17
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Localization (release) of corticotropin-releasing factor associated with reprotox - general 2 and stress
5) Confidence 0.78 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.10 Pain Relevance 0.17
Inflammatory mediators activate hypothalamic pathways, and a negative feedback loop, mediated by CRF release, has been proposed because animals with impaired hypothalamic CRF responses are more susceptible to inflammatory stimuli.
Localization (release) of CRF associated with inflammatory mediators and inflammatory stimuli
6) Confidence 0.78 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11171612 Disease Relevance 0.96 Pain Relevance 0.54
Naloxone causes ACTH release in humans by removing an endogenous inhibitory opioid tone on central noradrenergic pathways stimulatory to hypothalamic corticotropin-releasing hormone (CRH) secretion.
Localization (secretion) of CRH associated with narcan and opioid
7) Confidence 0.78 Published 1997 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 9171947 Disease Relevance 0.08 Pain Relevance 1.06
Angiotensin II (AT II) has a direct stimulating action on CRH and vasopressin release from the hypothalamus [18,19]. 4.
Localization (release) of CRH in hypothalamus
8) Confidence 0.78 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.24 Pain Relevance 0.28
Prior stress enhances the response to an inflammatory stimulus by a mechanism that is independent of the release of hypothalamic corticotropin-releasing factor (CRF) or arginine vasopressin.
Localization (release) of CRF associated with stress and inflammatory stimuli
9) Confidence 0.78 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11171612 Disease Relevance 0.99 Pain Relevance 0.37
The mechanism of this response is thought to be via increased hypothalamic CRH secretion.
Localization (secretion) of CRH
10) Confidence 0.78 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7829620 Disease Relevance 0.06 Pain Relevance 0.33
METHODS: We administered interleukin-6 (IL-6; 3 microg/kg of body weight subcutaneously), a cytokine capable of stimulating hypothalamic CRH release, and measured plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and catecholamines and their metabolites and precursors.
Localization (release) of CRH in plasma
11) Confidence 0.78 Published 2000 Journal Arthritis Rheum. Section Body Doc Link 10765933 Disease Relevance 0.19 Pain Relevance 0
In vitro, procaine and lidocaine both produced significant dose-related increases in immunoreactive CRH release from rat hypothalami, maximal at 10(-6) M, that were blocked by carbamazepine, a limbic anticonvulsant used in the management of mood disorders.
Localization (release) of CRH associated with affective disorder, anticonvulsant, lidocaine and carbamazepine
12) Confidence 0.78 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138967 Disease Relevance 0.50 Pain Relevance 0.55
Because corticotropin-releasing hormone (CRH) mimics the behavioral and physiologic responses to stress and activates limbic structures in experimental animals, the effects of procaine and lidocaine on immunoreactive CRH release from rat hypothalami in vitro were also explored.
Localization (release) of CRH associated with stress and lidocaine
13) Confidence 0.78 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138967 Disease Relevance 0.41 Pain Relevance 0.52
An inappropriate response to cortisol in chronic inflammation has been reported, i.e., a decrease of the corticotropin-releasing-hormone (CRH) secretion by the hypothalamus.
Localization (secretion) of CRH in hypothalamus associated with inflammation
14) Confidence 0.78 Published 1994 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 7955611 Disease Relevance 0.72 Pain Relevance 0.66
For example, Wang et al. [16] identified four genes that activate the secretion of corticotrophin-releasing hormone (CRH) from the hypothalamus and that show significantly higher expression in depressed than in nondepressed persons.
Localization (secretion) of CRH in hypothalamus
15) Confidence 0.78 Published 2010 Journal Depression Research and Treatment Section Body Doc Link PMC2989690 Disease Relevance 1.42 Pain Relevance 0.28
CRH is produced by fetomaternal tissues and secreted into the maternal circulation, so that during pregnancy the maternal plasma levels of this hormone increase while of the corresponding binding protein (CRH-BP) is reduced [14,15].
Localization (secreted) of CRH in plasma
16) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.40 Pain Relevance 0.12
The biopsies were examined by electron and confocal microscopy for HRP and CRH receptor localisation, respectively.
Spec (examined) Localization (localisation) of CRH receptor
17) Confidence 0.75 Published 2008 Journal Gut Section Body Doc Link 17525093 Disease Relevance 0 Pain Relevance 0
This may be interpreted as the fact that the acetylcholinergic effect of galantamine facilitates the release of CRH hormone and in turn, causes elevated DHEAS levels to decrease through recovering the existing tentative disturbance in metabolic shift from cortisol to DHEAS.
Localization (release) of CRH
18) Confidence 0.75 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.73 Pain Relevance 0
Finally, the cholinergic effect of galantamine that facilitates release of CRH may cause reduction in DHEAS levels and the normalization of high DHEAS/cortisol molar ratio.
Localization (release) of CRH in molar
19) Confidence 0.75 Published 2009 Journal Psychiatry Investigation Section Body Doc Link PMC2796068 Disease Relevance 0.52 Pain Relevance 0.08
These results show that modulation of peripheral plasma catecholamine levels within physiological limits does not affect CRF-stimulated release of ACTH or the adrenal response in normal man.
Localization (release) of CRF in plasma associated with catecholamine
20) Confidence 0.75 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3024878 Disease Relevance 0 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox