INT54540

Context Info Confidence 0.58 First Reported 1994 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 2.64 Pain Relevance 2.26

mitochondrion (Cps1) protein complex (Cps1) ligase activity (Cps1) cytoplasm (Cps1)

Anatomy Link Frequency urine 2 CGI 1 thoracic 1 Cps1 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 18 98.56 antagonist 3 95.52 Cannabinoid 6 90.08 Pain 4 85.12 anesthesia 2 84.56 Pain score 1 84.48 Lasting pain 1 75.00 backache 1 71.76 Hyperalgesia 2 71.24 Inflammation 3 70.72

Disease Link Frequency Relevance Heat Maple Syrup Urine Disease 6 99.58 Necrosis 4 94.44 Renal Failure 2 85.76 Pain 6 85.12 Death 2 84.92 Hyperammonemia 4 82.48 Inborn Error Of Metabolism 6 81.28 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 4 76.44 Low Back Pain 1 71.76 Hyperalgesia 2 71.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We describe the use of continuous venovenous haemofiltration (CVVH) or haemodiafiltration (CVVHD) in three infants with maple syrup urine disease (MSUD) and one child with carbamyl phosphate synthetase (CPS) deficiency.

Negative_regulation (deficiency) of CPS in urine associated with maple syrup urine disease

1) Confidence 0.58 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7917860 Disease Relevance 0.69 Pain Relevance 0.08

We describe the use of continuous venovenous haemofiltration (CVVH) or haemodiafiltration (CVVHD) in three infants with maple syrup urine disease (MSUD) and one child with carbamyl phosphate synthetase (CPS) deficiency.

Negative_regulation (deficiency) of carbamyl phosphate synthetase in urine associated with maple syrup urine disease

2) Confidence 0.58 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7917860 Disease Relevance 0.69 Pain Relevance 0.08

Hepatic CPS-I activities were decreased in mice given hepatotoxic doses of acetaminophen.

Negative_regulation (decreased) of CPS-I associated with paracetamol

3) Confidence 0.57 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9344900 Disease Relevance 0.28 Pain Relevance 0.70

Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice.

Negative_regulation (Inhibition) of carbamyl phosphate synthetase-I associated with paracetamol

4) Confidence 0.57 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9344900 Disease Relevance 0.17 Pain Relevance 0.47

Data indicate that changes to good postural habits are represented by a significant decrease in the activity of the cervical paraspinal area (CPS), whereas in the trapezius and the thoracic area (T1, T6), the activity of the muscles is significantly increased.

Negative_regulation (ecrease ) of CPS in thoracic

5) Confidence 0.35 Published 1997 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 9428967 Disease Relevance 0.23 Pain Relevance 0.23

In a logistic regression analysis, history of abuse did not predict treatment response as measured by > or =25% reduction in CPS (OR = 0.481, CI = 0.164-1.406, P = 0.181), while the drug status (paroxetine CR) was significantly associated with treatment response as defined by a CGI improvement score of 1-2 (OR = 12.121, CI = 2.923-50.271, P = 0.001).

Negative_regulation (reduction) of CPS in CGI

6) Confidence 0.35 Published 2009 Journal J Clin Pharm Ther Section Body Doc Link 19125906 Disease Relevance 0 Pain Relevance 0

The primary outcome was treatment response defined as > or =25% reduction in composite pain scores (CPS) on the IVRS from randomization to end of treatment.

Negative_regulation (reduction) of CPS

7) Confidence 0.35 Published 2009 Journal J Clin Pharm Ther Section Body Doc Link 19125906 Disease Relevance 0 Pain Relevance 0

Indeed, a significant decrease in CPS-WST(0,1,2) scores for both phases was detected in most of all of the groups, except SR141716A at 5 mg/kg.

Negative_regulation (ease in ) of CPS-WST

8) Confidence 0.04 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10822060 Disease Relevance 0.45 Pain Relevance 0.70

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