INT54540

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.64
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cps1) protein complex (Cps1) ligase activity (Cps1)
cytoplasm (Cps1)
Anatomy Link Frequency
urine 2
CGI 1
thoracic 1
Cps1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 98.56 Very High Very High Very High
antagonist 3 95.52 Very High Very High Very High
Cannabinoid 6 90.08 High High
Pain 4 85.12 High High
anesthesia 2 84.56 Quite High
Pain score 1 84.48 Quite High
Lasting pain 1 75.00 Quite High
backache 1 71.76 Quite High
Hyperalgesia 2 71.24 Quite High
Inflammation 3 70.72 Quite High
Disease Link Frequency Relevance Heat
Maple Syrup Urine Disease 6 99.58 Very High Very High Very High
Necrosis 4 94.44 High High
Renal Failure 2 85.76 High High
Pain 6 85.12 High High
Death 2 84.92 Quite High
Hyperammonemia 4 82.48 Quite High
Inborn Error Of Metabolism 6 81.28 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 76.44 Quite High
Low Back Pain 1 71.76 Quite High
Hyperalgesia 2 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe the use of continuous venovenous haemofiltration (CVVH) or haemodiafiltration (CVVHD) in three infants with maple syrup urine disease (MSUD) and one child with carbamyl phosphate synthetase (CPS) deficiency.
Negative_regulation (deficiency) of CPS in urine associated with maple syrup urine disease
1) Confidence 0.58 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7917860 Disease Relevance 0.69 Pain Relevance 0.08
We describe the use of continuous venovenous haemofiltration (CVVH) or haemodiafiltration (CVVHD) in three infants with maple syrup urine disease (MSUD) and one child with carbamyl phosphate synthetase (CPS) deficiency.
Negative_regulation (deficiency) of carbamyl phosphate synthetase in urine associated with maple syrup urine disease
2) Confidence 0.58 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7917860 Disease Relevance 0.69 Pain Relevance 0.08
Hepatic CPS-I activities were decreased in mice given hepatotoxic doses of acetaminophen.
Negative_regulation (decreased) of CPS-I associated with paracetamol
3) Confidence 0.57 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9344900 Disease Relevance 0.28 Pain Relevance 0.70
Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice.
Negative_regulation (Inhibition) of carbamyl phosphate synthetase-I associated with paracetamol
4) Confidence 0.57 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 9344900 Disease Relevance 0.17 Pain Relevance 0.47
Data indicate that changes to good postural habits are represented by a significant decrease in the activity of the cervical paraspinal area (CPS), whereas in the trapezius and the thoracic area (T1, T6), the activity of the muscles is significantly increased.
Negative_regulation (ecrease ) of CPS in thoracic
5) Confidence 0.35 Published 1997 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 9428967 Disease Relevance 0.23 Pain Relevance 0.23
In a logistic regression analysis, history of abuse did not predict treatment response as measured by > or =25% reduction in CPS (OR = 0.481, CI = 0.164-1.406, P = 0.181), while the drug status (paroxetine CR) was significantly associated with treatment response as defined by a CGI improvement score of 1-2 (OR = 12.121, CI = 2.923-50.271, P = 0.001).
Negative_regulation (reduction) of CPS in CGI
6) Confidence 0.35 Published 2009 Journal J Clin Pharm Ther Section Body Doc Link 19125906 Disease Relevance 0 Pain Relevance 0
The primary outcome was treatment response defined as > or =25% reduction in composite pain scores (CPS) on the IVRS from randomization to end of treatment.
Negative_regulation (reduction) of CPS
7) Confidence 0.35 Published 2009 Journal J Clin Pharm Ther Section Body Doc Link 19125906 Disease Relevance 0 Pain Relevance 0
Indeed, a significant decrease in CPS-WST(0,1,2) scores for both phases was detected in most of all of the groups, except SR141716A at 5 mg/kg.
Negative_regulation (ease in ) of CPS-WST
8) Confidence 0.04 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10822060 Disease Relevance 0.45 Pain Relevance 0.70

General Comments

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