INT5455

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 7.31
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
hypothalamus 4
pituitary 4
plasma 2
blood 2
corticotroph 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 3 100.00 Very High Very High Very High
Endogenous opioid 2 99.88 Very High Very High Very High
carbamazepine 39 99.84 Very High Very High Very High
Enkephalin 6 99.82 Very High Very High Very High
Opioid 12 99.80 Very High Very High Very High
narcan 34 99.70 Very High Very High Very High
Inflammation 3 99.44 Very High Very High Very High
gABA 4 99.40 Very High Very High Very High
anticonvulsant 3 99.00 Very High Very High Very High
Locus ceruleus 3 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 100.00 Very High Very High Very High
Stress 12 99.80 Very High Very High Very High
Disease 69 99.60 Very High Very High Very High
INFLAMMATION 3 99.44 Very High Very High Very High
Cancer 56 99.22 Very High Very High Very High
Reprotox - General 2 4 98.88 Very High Very High Very High
Affective Disorder 3 98.68 Very High Very High Very High
Pituitary Cancer 20 98.26 Very High Very High Very High
Pain 2 97.88 Very High Very High Very High
Convulsion 2 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, higher plasma SV levels or more sustained exposure to SV may be necessary to inhibit hypothalamic secretion of CRH.
Negative_regulation (inhibit) of Localization (secretion) of CRH in plasma
1) Confidence 0.49 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.17
The opioid peptides inhibit the secretion of CRH into the portal blood, however, they exert a potent stimulatory effect on prolactin secretion in the rat and man.
Negative_regulation (inhibit) of Localization (secretion) of CRH in blood associated with opioid
2) Confidence 0.47 Published 1989 Journal Toxicol Pathol Section Abstract Doc Link 2571183 Disease Relevance 0 Pain Relevance 0.57
We conclude that glucocorticoids and morphine agonists exert interactive inhibitory effects on ACTH release in humans, probably by virtue of their suppression of CRH release from the hypothalamus.
Negative_regulation (suppression) of Localization (release) of CRH in hypothalamus associated with agonist and morphine
3) Confidence 0.46 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3036903 Disease Relevance 0 Pain Relevance 0.63
Opioids have been shown to inhibit CRF release.
Negative_regulation (inhibit) of Localization (release) of CRF associated with opioid
4) Confidence 0.42 Published 1988 Journal Int. J. Neurosci. Section Abstract Doc Link 3165969 Disease Relevance 0.42 Pain Relevance 0.46
In vitro, procaine and lidocaine both produced significant dose-related increases in immunoreactive CRH release from rat hypothalami, maximal at 10(-6) M, that were blocked by carbamazepine, a limbic anticonvulsant used in the management of mood disorders.
Negative_regulation (blocked) of Localization (release) of CRH associated with affective disorder, anticonvulsant, lidocaine and carbamazepine
5) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138967 Disease Relevance 0.51 Pain Relevance 0.56
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Negative_regulation (inhibits) of Localization (release) of CRF associated with reprotox - general 2 and stress
6) Confidence 0.41 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.13 Pain Relevance 0.18
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Negative_regulation (inhibits) of Localization (release) of corticotropin-releasing factor associated with reprotox - general 2 and stress
7) Confidence 0.41 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.13 Pain Relevance 0.18
An inappropriate response to cortisol in chronic inflammation has been reported, i.e., a decrease of the corticotropin-releasing-hormone (CRH) secretion by the hypothalamus.
Negative_regulation (decrease) of Localization (secretion) of CRH in hypothalamus associated with inflammation
8) Confidence 0.41 Published 1994 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 7955611 Disease Relevance 0.72 Pain Relevance 0.67
Although CBZ has been shown to inhibit hypothalamic CRH secretion in vitro, limited data suggest that systemic CBZ induces pituitary-adrenal activation.
Negative_regulation (inhibit) of Localization (secretion) of CRH in pituitary associated with carbamazepine
9) Confidence 0.41 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1309836 Disease Relevance 0.29 Pain Relevance 0.40
Gamma-aminobutyric acid (GABA) and endogenous opioids each inhibit hypothalamic CRH secretion.
Negative_regulation (inhibit) of Localization (secretion) of CRH associated with gaba and endogenous opioid
10) Confidence 0.36 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.57
Alprazolam (APZ) attenuates the ACTH release in response to Nal in normal individuals, probably by inhibiting CRH release.
Negative_regulation (inhibiting) of Localization (release) of CRH associated with narcan
11) Confidence 0.30 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663654 Disease Relevance 1.11 Pain Relevance 0.37
This pituitary-driven increase in cortisol secretion combined with the expected reduction in centrally directed CRH secretion could contribute to the anticonvulsant properties of CBZ.
Negative_regulation (reduction) of Localization (secretion) of CRH in pituitary associated with anticonvulsant and carbamazepine
12) Confidence 0.30 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1309836 Disease Relevance 0 Pain Relevance 0.48
In preclinical studies, pasireotide has shown significant inhibition of basal and stimulated ACTH release in human ACTH-secreting pituitary adenomas [66,67] and in AtT-20 murine corticotroph tumor cells [66,68], as well as significant inhibition of corticotropin-releasing hormone (CRH)-induced ACTH release in rats (Figure 1) [69,70].
Negative_regulation (inhibition) of Localization (release) of corticotropin-releasing hormone in corticotroph associated with cancer and pituitary cancer
13) Confidence 0.09 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.56 Pain Relevance 0.10
In contrast, in patients with Cushing's disease, FK 33-824 did not inhibit hCRH-induced hormone release.
Negative_regulation (inhibit) of Localization (release) of hCRH associated with disease
14) Confidence 0.05 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.52 Pain Relevance 0.29
FK 33-824, a met-enkephalin analog, blocks corticotropin-releasing hormone-induced adrenocorticotropin secretion in normal subjects but not in patients with Cushing's disease.
Negative_regulation (blocks) of Localization (secretion) of corticotropin-releasing hormone associated with enkephalin and disease
15) Confidence 0.04 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 3023423 Disease Relevance 0.49 Pain Relevance 0.34
Stimulation by hCRF of C-peptide release in type 2 diabetics during concomitant opioid receptor blockade.
Negative_regulation (blockade) of Localization (release) of hCRF associated with diabetes mellitus, narcan and opioid receptor
16) Confidence 0.00 Published 1988 Journal Klin. Wochenschr. Section Title Doc Link 2836651 Disease Relevance 0.28 Pain Relevance 0.43

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