INT54555

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.41
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
spinal cord 1
CSF 1
arm 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 9 99.90 Very High Very High Very High
fluoxetine 30 99.40 Very High Very High Very High
Central nervous system 6 93.08 High High
headache 4 91.24 High High
intrathecal 1 75.00 Quite High
sSRI 6 73.16 Quite High
Serotonin 6 67.36 Quite High
Pain 19 8.12 Low Low
palliative 9 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 12 99.66 Very High Very High Very High
Toxicity 8 97.60 Very High Very High Very High
Fatigue 1 97.08 Very High Very High Very High
Systemic Lupus Erythematosus 8 95.64 Very High Very High Very High
Pancreatic Cancer 61 93.04 High High
Headache 2 91.24 High High
Death 30 90.04 High High
Wrinkles 2 89.00 High High
Stress 21 88.24 High High
Cancer 74 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe these four patients in whom immunological work-up revealed CSF antinuclear, anti-DNA, anti-SSA/Ro, anti-SSB/La and antineuronal autoantibodies.
Negative_regulation (revealed) of SSA in CSF
1) Confidence 0.41 Published 1994 Journal Lupus Section Abstract Doc Link 7920611 Disease Relevance 0.84 Pain Relevance 0.37
This highlights again the importance of access to modern medicine and points to the likely benefit of reviving the CHW concept in rural SSA [9,66].
Negative_regulation (reviving) of SSA
2) Confidence 0.35 Published 2009 Journal Malar J Section Body Doc Link PMC2790466 Disease Relevance 0.50 Pain Relevance 0
Moreover, in both COS-7 and RCS cells, shRNA 3B reduced the elevated CRT levels that result from the overexpression of COMP.
Negative_regulation (reduced) of CRT associated with chondrosarcoma
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.36 Pain Relevance 0
In the CRT, speed decreased in the sensitive
Negative_regulation (decreased) of CRT
4) Confidence 0.14 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1552030 Disease Relevance 0.13 Pain Relevance 0
The concurrent CRT was found to be more myelosuppressive and was also associated with considerable gastrointestinal toxicity and fatigue.
Negative_regulation (myelosuppressive) of CRT associated with toxicity and fatigue
5) Confidence 0.13 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.72 Pain Relevance 0
Larvae exposed to 4.6 microM fluoxetine for 24 h on 4 or 5 dpf showed a significant decrease in SSA by day 6 with no recovery through 14 dpf.
Negative_regulation (decrease) of SSA associated with fluoxetine
6) Confidence 0.05 Published 2007 Journal Neurotoxicol Teratol Section Abstract Doc Link 17761399 Disease Relevance 0.07 Pain Relevance 0.72
Fluoxetine exposure at 3 dpf for 24 h resulted in a transient decrease in SSA through 7 dpf with a complete recovery by 8 dpf.
Negative_regulation (decrease) of SSA associated with fluoxetine
7) Confidence 0.05 Published 2007 Journal Neurotoxicol Teratol Section Abstract Doc Link 17761399 Disease Relevance 0.07 Pain Relevance 0.70
These results suggest a correlation between decreased concentration of SERT and 5-HT(1A) receptor transcripts in spinal cord and decreased SSA subsequent to fluoxetine exposure.
Negative_regulation (decreased) of SSA in spinal cord associated with fluoxetine and spinal cord
8) Confidence 0.05 Published 2007 Journal Neurotoxicol Teratol Section Abstract Doc Link 17761399 Disease Relevance 0.07 Pain Relevance 0.61
On the other hand, throughout the course of the 24-week intervention, there were significant decreasing trends in levels of serum Bil, ALP, Crt, Ca, and Pi over time with different magnitude in each treatment arm.
Negative_regulation (decreasing) of Crt in arm
9) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.14 Pain Relevance 0
In this study, we observed decreasing trends in the levels of serum Bil, ALP, Crt, Ca, and Pi over the study period (Table 2).
Negative_regulation (decreasing) of Crt
10) Confidence 0.05 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.38 Pain Relevance 0
The potentiated effect could be detected with doses of SSa as low as 2 ?
Negative_regulation (doses) of SSa
11) Confidence 0.03 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3006358 Disease Relevance 1.11 Pain Relevance 0

General Comments

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