INT54556

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (SSB) nucleus (SSB)
Anatomy Link Frequency
CSF 1
interneurons 1
SSB (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 12 98.16 Very High Very High Very High
long-term potentiation 42 93.96 High High
Central nervous system 8 93.08 High High
headache 1 91.24 High High
amygdala 31 86.92 High High
intrathecal 1 75.00 Quite High
antagonist 15 69.40 Quite High
Action potential 3 62.12 Quite High
Thalamus 2 39.80 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 8 95.64 Very High Very High Very High
Headache 1 91.24 High High
Congenital Anomalies 1 81.60 Quite High
Anxiety Disorder 27 29.16 Quite Low
Depression 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Amnesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We describe these four patients in whom immunological work-up revealed CSF antinuclear, anti-DNA, anti-SSA/Ro, anti-SSB/La and antineuronal autoantibodies.
Negative_regulation (revealed) of SSB in CSF
1) Confidence 0.41 Published 1994 Journal Lupus Section Abstract Doc Link 7920611 Disease Relevance 0.84 Pain Relevance 0.37
We further showed that norepinephrine reduced the frequency of spontaneous inhibitory postsynaptic currents in the LA and reduced the peak amplitude of disynaptic GABAergic inhibitory postsynaptic currents, strengthening the notion that NE may permit the induction of LTP by decreasing inhibition of principal neurons by local circuit interneurons.
Negative_regulation (reduced) of LA in interneurons associated with gabaergic and long-term potentiation
2) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0 Pain Relevance 0.46

General Comments

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