INT54571

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2011
Negated 3
Speculated 8
Reported most in Body
Documents 263
Total Number 271
Disease Relevance 138.99
Pain Relevance 87.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
T lymphocytes 7
monocytes 6
MNCs 5
neutrophils 5
endothelial cells 4
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 944 100.00 Very High Very High Very High
Morphine 103 100.00 Very High Very High Very High
COX2 36 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
Spinal cord 13 99.98 Very High Very High Very High
Inflammatory stimuli 23 99.92 Very High Very High Very High
fibrosis 19 99.92 Very High Very High Very High
cytokine 506 99.84 Very High Very High Very High
qutenza 203 99.84 Very High Very High Very High
fluoxetine 45 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1196 100.00 Very High Very High Very High
Apnoea 89 99.98 Very High Very High Very High
Death 136 99.96 Very High Very High Very High
Fibrosis 27 99.92 Very High Very High Very High
Cancer 539 99.84 Very High Very High Very High
Apoptosis 280 99.84 Very High Very High Very High
Skin Cancer 103 99.84 Very High Very High Very High
Nicotine Addiction 83 99.84 Very High Very High Very High
Coronary Artery Disease 43 99.80 Very High Very High Very High
Disease 427 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive NF-kappaB activation has been detected in AML cells and NF-kappaB inhibition is therefore a possible therapeutic strategy in AML.
Positive_regulation (activation) of NF-kappaB associated with acute myeloid leukemia
1) Confidence 0.70 Published 2009 Journal Crit Rev Oncog Section Abstract Doc Link 20136626 Disease Relevance 0.83 Pain Relevance 0.08
This is in accordance with the observation that NFkB activation suppress the action of PXR and vice versa [62,63].
Positive_regulation (activation) of NFkB
2) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.95 Pain Relevance 0.43
Furthermore, interaction between meat and NFkB may be caused by a lower activation of NFkB del-allele relative to the ins-allele resulting in a high load of reactive oxygen species provided by heme degradation and which may contribute to carcinogenesis [60].
Positive_regulation (activation) of NFkB
3) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.41 Pain Relevance 0
Evidence of NF-kappaB activation was determined by electromobility shift assays (EMSAs) with the NF-kappaB binding-site-specific probe and nuclear proteins isolated from the buffy coat of blood obtained at the beginning of the procedure.
Positive_regulation (activation) of NF-kappaB in blood
4) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.16 Pain Relevance 0
A lack of NF-kappaB activation was not due to a lack of functional cell/protein because NF-kappaB was appropriately activated by lipopolysaccharide ex vivo in all patients.
Positive_regulation (activation) of NF-kappaB
5) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.12 Pain Relevance 0
Furthermore, because NF-kappaB is activated before a clinical event, it may be mechanistically involved in the plaque disruption that produces acute coronary artery syndromes.


Positive_regulation (activated) of NF-kappaB in coronary artery
6) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0
NF-kappaB activation was not a nonspecific response of all transcription factors because neither Sp1 or Oct1 was activated in patients with activated NF-kappaB.
Positive_regulation (activated) of NF-kappaB
7) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0
Because acute inflammation may play a role in coronary artery plaque rupture, it was hypothesized that NF-kappaB activation correlated with coronary artery disease (CAD) activity.
Spec (hypothesized) Positive_regulation (activation) of NF-kappaB in coronary artery associated with coronary artery disease, inflammation and rupture
8) Confidence 0.69 Published 1998 Journal Circulation Section Abstract Doc Link 9788823 Disease Relevance 0.83 Pain Relevance 0.20
NF-kappaB activation was not a nonspecific response of all transcription factors because neither Sp1 or Oct1 was activated in patients with activated NF-kappaB.
Positive_regulation (activation) of NF-kappaB
9) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.10 Pain Relevance 0
A lack of NF-kappaB activation was not due to a lack of functional cell/protein because NF-kappaB was appropriately activated by lipopolysaccharide ex vivo in all patients.
Neg (not) Positive_regulation (activated) of NF-kappaB
10) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.11 Pain Relevance 0
Nuclear factor-kappaB is selectively and markedly activated in humans with unstable angina pectoris.
Positive_regulation (activated) of Nuclear factor-kappaB associated with angina
11) Confidence 0.69 Published 1998 Journal Circulation Section Title Doc Link 9788823 Disease Relevance 0.64 Pain Relevance 0.24
METHODS AND RESULTS: Evidence of NF-kappaB activation in the circulation of 102 consecutive patients without an acute myocardial infarction who were undergoing cardiac catheterization was determined.
Positive_regulation (activation) of NF-kappaB
12) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.20 Pain Relevance 0
Analyses showed that 17 of 19 patients with USA had marked activation of NF-kappaB.
Positive_regulation (activation) of NF-kappaB
13) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.13 Pain Relevance 0
CONCLUSIONS: These data show that NF-kappaB is specifically and significantly activated in unstable angina pectoris and is not affected by severity of CAD or medical therapy.
Positive_regulation (activated) of NF-kappaB
14) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0 Pain Relevance 0
Despite a significant number of patients with severe CAD (69%), only 2 of the 83 without USA showed marked NF-kappaB activation.
Positive_regulation (activation) of NF-kappaB
15) Confidence 0.69 Published 1998 Journal Circulation Section Body Doc Link 9788823 Disease Relevance 0.12 Pain Relevance 0
The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
Positive_regulation (activation) of NF-kappa B associated with aspirin, inflammation and cinod
16) Confidence 0.69 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.38 Pain Relevance 0.27
Activation of the transcription factor nuclear factor-kappa B (NF-kappa B) has been implicated in pancreatic tumorigenesis.
Positive_regulation (Activation) of transcription factor nuclear factor-kappa B
17) Confidence 0.69 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.24 Pain Relevance 0
Activation of the transcription factor nuclear factor-kappa B (NF-kappa B) has been implicated in pancreatic tumorigenesis.
Positive_regulation (Activation) of NF-kappa B
18) Confidence 0.69 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15827332 Disease Relevance 0.24 Pain Relevance 0
Immunostaining grades for activated NF-kappaB were significantly higher in UAP compared with SAP (2.60+/-0.1 vs. 1.98+/-0.18; P<0.01).
Positive_regulation (activated) of NF-kappaB
19) Confidence 0.68 Published 2002 Journal Atherosclerosis Section Body Doc Link 11755932 Disease Relevance 0.13 Pain Relevance 0
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
Positive_regulation (activation) of NF-kappa B
20) Confidence 0.68 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.19 Pain Relevance 0.24

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