INT54572

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 21.45
Pain Relevance 15.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
endothelial cells 8
neutrophils 3
chondrocytes 2
neurons 2
HL-60 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 30 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
qutenza 51 99.98 Very High Very High Very High
aspirin 6 99.98 Very High Very High Very High
melanocortin 1 receptor 11 99.76 Very High Very High Very High
Kinase C 5 99.76 Very High Very High Very High
antagonist 9 99.74 Very High Very High Very High
substance P 11 99.52 Very High Very High Very High
cINOD 28 99.40 Very High Very High Very High
Inflammatory response 9 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 43 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Apoptosis 7 99.90 Very High Very High Very High
Skin Cancer 34 99.84 Very High Very High Very High
Multiple Myeloma 7 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.44 Very High Very High Very High
Infection 7 99.44 Very High Very High Very High
INFLAMMATION 82 99.36 Very High Very High Very High
Leukemia 1 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B, which further explains the mechanism of action of these drugs.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappa B associated with aspirin, inflammation and cinod
1) Confidence 0.58 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.39 Pain Relevance 0.28
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kappa B
2) Confidence 0.57 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.50 Pain Relevance 0.30
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
Negative_regulation (suppressed) of Positive_regulation (accumulation) of NF-kappa B
3) Confidence 0.57 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.37 Pain Relevance 0.28
A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons.
Negative_regulation (inhibits) of Positive_regulation (activation) of NF-kappa B promoter in neurons associated with antagonist, morphine and substance p
4) Confidence 0.57 Published 2004 Journal J. Neurosci. Res. Section Title Doc Link 14743438 Disease Relevance 0.10 Pain Relevance 1.50
These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.
Negative_regulation (suppression) of Positive_regulation (activation) of NF-kappaB
5) Confidence 0.56 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.24 Pain Relevance 0.27
Furthermore, harpagoside dose-dependently inhibited LPS-stimulated NF-kappaB promoter activity in a gene reporter assay in RAW 264.7 cells, indicating that harpagoside interfered with the activation of gene transcription.
Negative_regulation (inhibited) of Positive_regulation (stimulated) of NF-kappaB in RAW 264
6) Confidence 0.56 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.21 Pain Relevance 0.32
Accordingly, inhibition of NF-kappaB activation, leading to the inhibition of COX, offers a new approach in lung cancer prevention.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kappaB in lung associated with lung cancer
7) Confidence 0.55 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10964107 Disease Relevance 0.15 Pain Relevance 0.30
Likewise, both compounds inhibited NF-kappaB and AP-1 activation in cultured human promyelocytic leukemia (HL-60) cells stimulated with TPA.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in HL-60 associated with leukemia
8) Confidence 0.46 Published 2000 Journal Biofactors Section Abstract Doc Link 11216470 Disease Relevance 0.50 Pain Relevance 0.32
Indirect protection is afforded by antioxidants, which reduce activation of NF kappa B, thereby preventing up-regulation of cytokine production by oxidants.
Negative_regulation (reduce) of Positive_regulation (activation) of NF kappa B associated with cytokine
9) Confidence 0.44 Published 1994 Journal New Horiz Section Abstract Doc Link 7922442 Disease Relevance 0.74 Pain Relevance 0.38
Our data suggest that attenuation of IL-1beta-induced alpha(2)M synthesis/release by blocking NF-kappaB activation may potentially be 'protective' against the development of late-onset AD.
Negative_regulation (blocking) of Positive_regulation (activation) of NF-kappaB associated with disease
10) Confidence 0.43 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.72 Pain Relevance 0.42
Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kappaB associated with analgesic, apoptosis and morphine
11) Confidence 0.42 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9837747 Disease Relevance 0.61 Pain Relevance 0.88
High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
Negative_regulation (suppression) of Positive_regulation (activation) of NF-kappa B
12) Confidence 0.42 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.36 Pain Relevance 0.28
Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.
Negative_regulation (decrease) of Positive_regulation (activation) of NF-kappaB
13) Confidence 0.42 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Body Doc Link 12242509 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: This study demonstrated that propofol, both at therapeutic concentrations and 5 times therapeutic concentrations, inhibited NF-kappaB activation in LPS-stimulated endothelial cells and was found to protect endothelial cells against LPS-induced barrier dysfunction.


Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB in endothelial cells
14) Confidence 0.41 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
RESULTS: Morphine inhibits lipopolysaccharide-induced NF-kappaB nuclear binding in human blood neutrophils and monocytes in a time-, concentration-, and naloxone-sensitive-dependent manner.
Negative_regulation (inhibits) of Positive_regulation (lipopolysaccharide-induced) of NF-kappaB in neutrophils
15) Confidence 0.41 Published 2000 Journal Anesthesiology Section Body Doc Link 10839919 Disease Relevance 0 Pain Relevance 0
BMS-470539 dose-dependently inhibited TNF-alpha-induced activation of a NF-kappaB transcriptional reporter in human melanoma cells, which endogenously express MC-1R.
Negative_regulation (inhibited) of Positive_regulation (activation) of NF-kappaB associated with skin cancer
16) Confidence 0.41 Published 2006 Journal J. Leukoc. Biol. Section Abstract Doc Link 16888084 Disease Relevance 0.42 Pain Relevance 0.40
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kappa B associated with cox2
17) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Title Doc Link 16203115 Disease Relevance 0.28 Pain Relevance 0.33
These results suggest that the inhibition of the expression of cyclooxygenase-2 and inducible nitric oxide by harpagoside involves suppression of NF-kappaB activation, thereby inhibiting downstream inflammation and subsequent pain events.
Negative_regulation (suppression) of Positive_regulation (activation) of NF-kappaB associated with pain and inflammation
18) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.37 Pain Relevance 0.32
Although these R-enantiomers inhibit nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB can selectively regulate Abeta42, Abeta42 reduction is not mediated by inhibition of NF-kappaB activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of NF-kappaB
19) Confidence 0.41 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12421374 Disease Relevance 0.54 Pain Relevance 0.40
Agents that can block NF-kappa B activation have potential to block downstream responses mediated through this transcription factor.
Negative_regulation (block) of Positive_regulation (activation) of NF-kappa B
20) Confidence 0.40 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8906816 Disease Relevance 0.10 Pain Relevance 0.41

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