INT54587

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Context Info
Confidence 0.27
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 5.54
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hras1) signal transduction (Hras1) Golgi apparatus (Hras1)
plasma membrane (Hras1) GTPase activity (Hras1)
Anatomy Link Frequency
PVN 2
neuronal 1
nerve 1
lungs 1
MNC 1
Hras1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.90 Very High Very High Very High
anesthesia 11 98.64 Very High Very High Very High
Central nervous system 54 97.16 Very High Very High Very High
Endogenous opioid 3 96.80 Very High Very High Very High
tetrodotoxin 1 87.40 High High
cocaine 8 76.32 Quite High
alcohol 7 76.08 Quite High
Morphine 4 72.00 Quite High
Neuropeptide 3 69.88 Quite High
cytokine 8 66.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 162 99.74 Very High Very High Very High
Cytomegalovirus Infection 9 99.26 Very High Very High Very High
Cancer 6 98.40 Very High Very High Very High
Central Nervous System Disease 48 97.16 Very High Very High Very High
Obesity 6 93.20 High High
Body Weight 21 91.16 High High
Parkinson's Disease 16 89.84 High High
Hyperphagia 1 87.20 High High
Multiple Sclerosis 79 86.16 High High
Sprains And Strains 8 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oncomouse is a transgenic mouse carrying an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter.
Positive_regulation (activated) of v-Ha-ras oncogene associated with targeted disruption and cancer
1) Confidence 0.27 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.27 Pain Relevance 0.22
Oncomouse is a transgenic mouse carrying an activated v-Ha-ras oncogene under the control of the mouse mammary tumor virus promoter.
Positive_regulation (activated) of v-Ha-ras oncogene associated with targeted disruption and cancer
2) Confidence 0.22 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792019 Disease Relevance 0.27 Pain Relevance 0.21
The CMV-Cre transgenic mice express Cre recombinase ubiquitously 32, and thus, the PINK1 RNAi transgene can be activated in every tissue.
Positive_regulation (activated) of transgene associated with targeted disruption and cytomegalovirus infection
3) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.79 Pain Relevance 0
In these transgenic mice, the expression of the PINK1 shRNA was tightly regulated by the Cre-loxP system and activation of the RNAi transgene resulted in silenced expression of the Pink1 gene in various tissues and to less than 5% of the normal levels in the central nerve system.
Positive_regulation (activation) of transgene in nerve associated with targeted disruption
4) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.96 Pain Relevance 0
After crossing with the CMV-Cre transgenic mice, the PINK1 RNAi transgene was activated by Cre-mediated excision of the intervening sequence from the promoter region.
Positive_regulation (activated) of transgene associated with targeted disruption and cytomegalovirus infection
5) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.58 Pain Relevance 0.06
A more rapid and transient pattern of transgene up-regulation in the PVN followed administration of intraperitoneal IL-1beta (10 microg/kg) with significant induction by 2 hours, peak levels reached by 4 hours, and a return toward basal levels by 6 hours.
Positive_regulation (up-regulation) of transgene in PVN
6) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.08 Pain Relevance 0.03
LPS induced up-regulation of the transgene was blocked by pretreatment with naltrexone, indicating an additional role for endogenous opioid systems in regulation of the PVN response to immune challenge.
Positive_regulation (up-regulation) of transgene in PVN associated with endogenous opioid
7) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0 Pain Relevance 0.10
IL-1beta (10-50 ng/mouse) administered intracerebroventricularly also led to up-regulation of the transgene 6 hours following infusion.
Positive_regulation (up-regulation) of transgene
8) Confidence 0.04 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10023810 Disease Relevance 0.06 Pain Relevance 0.03
Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.
Positive_regulation (activation) of ras in neuronal associated with agonist
9) Confidence 0.02 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16438962 Disease Relevance 0.07 Pain Relevance 0.17
RNAI produces sequence-specific reduction of gene expression in various mammalian in vitro systems [6] and most recently, RNAI was shown to suppress the expression and activity of a luciferase transgene in adult mice [7], suggesting that RNAI may become a valuable molecular and possibly clinical tool for use in vivo.
Positive_regulation (activity) of transgene
10) Confidence 0.02 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC134599 Disease Relevance 0.74 Pain Relevance 0
As shown in Fig. 1, the rAAV2 transgene is rapidly transferred and expressed in both the lungs (panel A) and intestines (panel B).
Positive_regulation (transferred) of rAAV2 transgene in lungs
11) Confidence 0.01 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC239997 Disease Relevance 0.22 Pain Relevance 0
The relationship between LPS treatment, CCL2 expression and MNC recruitment into the CNS remains partially understood, and seems to involve a complex immune regulatory mechanism rather than just a selective effect mediated by the upregulation of the CCL2 transgene.
Positive_regulation (upregulation) of transgene in MNC associated with central nervous system
12) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.49 Pain Relevance 0.29
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila.
Positive_regulation (Induction) of transgene
13) Confidence 0.00 Published 1994 Journal Cell Section Title Doc Link 7923376 Disease Relevance 0 Pain Relevance 0.09
Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected.
Positive_regulation (inducible) of transgene
14) Confidence 0.00 Published 1994 Journal Cell Section Abstract Doc Link 7923376 Disease Relevance 0 Pain Relevance 0.10

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