INT54593

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 9.05
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
monocytes 9
blood 4
endothelial cells 3
smooth muscle cells 2
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 65 99.98 Very High Very High Very High
Angina 16 98.72 Very High Very High Very High
Inflammation 146 94.92 High High
aspirin 7 83.60 Quite High
Paracetamol 3 75.00 Quite High
palliative 2 52.88 Quite High
cva 16 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 21 99.66 Very High Very High Very High
Sepsis 91 99.60 Very High Very High Very High
Brain Injury 144 99.56 Very High Very High Very High
Cv General 3 Under Development 17 98.72 Very High Very High Very High
Injury 115 98.14 Very High Very High Very High
Pulmonary Alveolar Proteinosis 69 97.96 Very High Very High Very High
Hyperglycemia 1 97.68 Very High Very High Very High
Thrombosis 23 96.88 Very High Very High Very High
Atherosclerotic Plaque 1 96.00 Very High Very High Very High
INFLAMMATION 179 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory anti-TF antibodies prolonged the clotting time of LPS-stimulated blood, indicating that the shortened clotting time was due to induction of TF expression.
Positive_regulation (induction) of Gene_expression (expression) of TF in blood associated with coagulation disorder
1) Confidence 0.68 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 10744152 Disease Relevance 1.04 Pain Relevance 0.18
METHODS AND RESULTS: Histamine (10(-8) to 10(-5) mol/L) induced TF expression in a concentration-dependent manner in human aortic endothelial and vascular smooth muscle cells, whereas TF pathway inhibitor expression remained unaffected.
Positive_regulation (induced) of Gene_expression (expression) of TF in smooth muscle cells
2) Confidence 0.62 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
The degree of tissue factor expression has been shown to correlate with metastatic potential and histological differentiation such that increased TF expression results an increased potential to metastasise and a more undifferentiated histological appearance [6,7].
Positive_regulation (increased) of Gene_expression (expression) of TF
3) Confidence 0.51 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1156959 Disease Relevance 1.10 Pain Relevance 0.05
Treatment with rhGH has been shown to reduce protein catabolism,13,14 increase muscle area and strength,14–18 increase erythropoietin synthesis,19 and to improve inflammation status and quality of life.20 A recent 6-month study showed a positive effect of GH treatment on lean body mass and cardiovascular risk factors.21 Furthermore, GH administration is associated with improvements in several nutritional parameters, such as increases in serum insulin-like growth factor-I (IGF-I),13,14,22 serum albumin14 and transferrin,13 and a reduction in blood urea nitrogen.13
Positive_regulation (increases) of Gene_expression (serum) of transferrin in blood associated with inflammation
4) Confidence 0.49 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.53 Pain Relevance 0.05
Hence, this study investigates whether histamine induces tissue factor (TF) expression in vascular cells.
Spec (whether) Positive_regulation (induces) of Gene_expression (expression) of TF
5) Confidence 0.45 Published 2005 Journal Circulation Section Abstract Doc Link 16009787 Disease Relevance 0.45 Pain Relevance 0.09
CONCLUSIONS: Histamine induces expression of TF, but not TF pathway inhibitor, in vascular cells via activation of the H1, but not H2, receptor.
Positive_regulation (induces) of Gene_expression (expression) of TF
6) Confidence 0.41 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
In contrast, histamine-stimulated TF expression was increased by phosphatidylinositol 3-kinase inhibition with LY294002 or wortmannin, whereas it was not affected by Rho-kinase inhibition with Y-27632 or hydroxyfasudil.
Positive_regulation (increased) of Gene_expression (expression) of TF
7) Confidence 0.41 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression.
Positive_regulation (induces) of Gene_expression (expression) of TF associated with sepsis
8) Confidence 0.40 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.10 Pain Relevance 0.21
Finally, the LIGHT-mediated enhancement of SR-A and TF expression appears to involve nuclear factor-kappaB activation.
Positive_regulation (enhancement) of Gene_expression (expression) of TF
9) Confidence 0.32 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Previous studies have shown liberation of a soluble TF from both vascular and extravascular sources following traumatic injury [36]. sTF is released into the circulation within hours of head injury [106], and inducible TF expression is rapidly upregulated on the surface of circulating monocytes after injury [38].
Positive_regulation (upregulated) of Gene_expression (expression) of TF in monocytes associated with injury and brain injury
10) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.93 Pain Relevance 0.11
TF expression can be induced by various stimulants such as C-reactive protein, oxLDL, hyperglycemia and adipocytokines.
Positive_regulation (induced) of Gene_expression (expression) of TF associated with hyperglycemia
11) Confidence 0.29 Published 2007 Journal Indian J. Exp. Biol. Section Abstract Doc Link 17249334 Disease Relevance 1.37 Pain Relevance 0.21
Previous studies have shown liberation of a soluble TF from both vascular and extravascular sources following traumatic injury [36]. sTF is released into the circulation within hours of head injury [106], and inducible TF expression is rapidly upregulated on the surface of circulating monocytes after injury [38].
Positive_regulation (upregulated) of Gene_expression (expression) of TF in monocytes associated with injury and brain injury
12) Confidence 0.23 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.93 Pain Relevance 0.11
In patients with unstable angina, both stimulated and unstimulated cells exhibited higher levels of TF expression than in patients with stable angina (P = .0001).
Positive_regulation (levels) of Gene_expression (expression) of TF
13) Confidence 0.14 Published 1994 Journal Circulation Section Body Doc Link 7923650 Disease Relevance 0.22 Pain Relevance 0
In children with meningococcal sepsis, monocytes exhibit increased TF expression [67].
Positive_regulation (increased) of Gene_expression (expression) of TF in monocytes associated with sepsis
14) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.35 Pain Relevance 0.11
Furthermore, in vitro studies showed that endotoxin and cytokine induced TF expression in monocytes and endothelial cells [66].
Positive_regulation (induced) of Gene_expression (expression) of TF in endothelial cells associated with cytokine
15) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.41 Pain Relevance 0.15
Alterations in iron metabolism were evidenced by elevations in both concentrations of iron and levels of transferrin, transferrin receptor, lactoferrin, and ferritin in all patients with PAP.
Positive_regulation (elevations) of Gene_expression (levels) of transferrin associated with pulmonary alveolar proteinosis
16) Confidence 0.11 Published 2008 Journal Respir Res Section Body Doc Link PMC2265287 Disease Relevance 1.03 Pain Relevance 0
In patients with unstable angina, monocyte TF expression (both stimulated and unstimulated, assessed by biological activity and by antigen techniques) and fibrinogen levels were correlated with the time elapsed from the beginning of the most recent episode of pain (.61 < r < .72, .02 < P < .0001).
Positive_regulation (unstimulated) of Gene_expression (expression) of TF in monocyte
17) Confidence 0.10 Published 1994 Journal Circulation Section Body Doc Link 7923650 Disease Relevance 0.16 Pain Relevance 0
Furthermore, in vitro studies showed that endotoxin and cytokine induced TF expression in monocytes and endothelial cells [66].
Positive_regulation (induced) of in monocytes Gene_expression (expression) of TF in endothelial cells associated with cytokine
18) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox