INT546

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Context Info
Confidence 0.48
First Reported 1972
Last Reported 2011
Negated 4
Speculated 11
Reported most in Abstract
Documents 311
Total Number 322
Disease Relevance 85.98
Pain Relevance 60.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 52
urine 12
blood 12
liver 5
platelet 4
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1029 100.00 Very High Very High Very High
cINOD 250 100.00 Very High Very High Very High
Morphine 156 100.00 Very High Very High Very High
lidocaine 123 100.00 Very High Very High Very High
aspirin 101 100.00 Very High Very High Very High
Analgesic 96 100.00 Very High Very High Very High
imagery 91 100.00 Very High Very High Very High
corticosteroid 80 100.00 Very High Very High Very High
Potency 79 100.00 Very High Very High Very High
Paracetamol 60 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 2626 100.00 Very High Very High Very High
INFLAMMATION 1193 100.00 Very High Very High Very High
Cancer 1182 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 147 100.00 Very High Very High Very High
Nicotine Addiction 119 100.00 Very High Very High Very High
Dyspnea 46 100.00 Very High Very High Very High
Pulmonary Disease 27 100.00 Very High Very High Very High
Hypolipidemia 6 100.00 Very High Very High Very High
Superior Vena Cava Syndrome 4 100.00 Very High Very High Very High
Brain Disease 2 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The impact of the postoperative acute phase response was investigated by obtaining daily serum samples from 18 surgical patients until the third postoperative day, and measuring piritramide protein binding, alpha1-acid glycoprotein, total protein and albumin.
albumin Binding (binding) of
1) Confidence 0.48 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027658 Disease Relevance 0.08 Pain Relevance 0
The binding to albumin was 88%.
albumin Binding (binding) of
2) Confidence 0.48 Published 1999 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 10027658 Disease Relevance 0.07 Pain Relevance 0
The binding of this lipophilic compound to plasma proteins and albumin was high (98%) and was not concentration dependent or altered in the presence of large concentrations of metabolites.
albumin Binding (binding) of in plasma
3) Confidence 0.48 Published 1981 Journal J Pharm Sci Section Abstract Doc Link 7264886 Disease Relevance 0.09 Pain Relevance 0.09
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
albumin Binding (binding) of associated with paracetamol
4) Confidence 0.48 Published 2007 Journal Drug Metab. Dispos. Section Title Doc Link 17510247 Disease Relevance 0.09 Pain Relevance 0.30
Thermodynamic parameters for the binding indicated that hydrogen bonding interactions are predominantly involved in the binding of these drugs to human serum albumin.
albumin Binding (binding) of
5) Confidence 0.48 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16600620 Disease Relevance 0.08 Pain Relevance 0.08
Binding of diltiazem to albumin, alpha 1-acid glycoprotein and to serum in man.
albumin Binding (Binding) of
6) Confidence 0.48 Published 1990 Journal J Clin Pharmacol Section Title Doc Link 2341578 Disease Relevance 0.71 Pain Relevance 0.27
Most of the nonsteroidals bind only to albumin, and therefore have a kind of built-in safety mechanism: once the albumin binding sites are saturated, free drug is rapidly excreted by the kidney and drug accumulation is prevented.
albumin Binding (bind) of in kidney
7) Confidence 0.48 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6356906 Disease Relevance 0.35 Pain Relevance 0.25
In plasma at 90% of indomethacin is bound to albumin at therapeutic plasma concentrations.
albumin Binding (bound) of in plasma
8) Confidence 0.48 Published 1981 Journal Clin Pharmacokinet Section Abstract Doc Link 7249487 Disease Relevance 0.23 Pain Relevance 0.11
Methadone binding to human plasma albumin.
albumin Binding (binding) of in plasma associated with methadone
9) Confidence 0.48 Published 1972 Journal Science Section Title Doc Link 5032355 Disease Relevance 0 Pain Relevance 0.39
Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin.
serum albumin Binding (binding) of associated with inflammation and cinod
10) Confidence 0.48 Published 1986 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 3714761 Disease Relevance 0.20 Pain Relevance 0.20
The binding to human serum albumin of two anti-inflammatory drugs, indomethacin and indoprofen, has been studied by chromatographic and spectroscopic techniques.
serum albumin Binding (binding) of associated with inflammation and cinod
11) Confidence 0.48 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3714761 Disease Relevance 0.17 Pain Relevance 0.17
Modelling of indometacin and diclofenac sodium binding to the molecule of human serum albumin.
serum albumin Binding (binding) of associated with diclofenac
12) Confidence 0.48 Published 1996 Journal Arzneimittelforschung Section Title Doc Link 8901151 Disease Relevance 0.10 Pain Relevance 0.20
These results suggest the role of hydrophobic interactions in the binding of arylpropionic acids to human serum albumin.
serum albumin Binding (binding) of
13) Confidence 0.48 Published 1997 Journal J Pharm Biomed Anal Section Abstract Doc Link 9408837 Disease Relevance 0.15 Pain Relevance 0.15
The binding of arylpropionic acids to human serum albumin was studied in vitro by equilibrium dialysis.
serum albumin Binding (binding) of
14) Confidence 0.48 Published 1997 Journal J Pharm Biomed Anal Section Abstract Doc Link 9408837 Disease Relevance 0.17 Pain Relevance 0.17
A possible relationship between lipophilicity and binding to human serum albumin was investigated for 11 arylpropionate non-steroidal anti-inflammatory drugs.
serum albumin Binding (binding) of associated with inflammation and cinod
15) Confidence 0.48 Published 1997 Journal J Pharm Biomed Anal Section Abstract Doc Link 9408837 Disease Relevance 0.17 Pain Relevance 0.17
Relationship between lipophilicity and binding to human serum albumin of arylpropionic acid non-steroidal anti-inflammatory drugs.
serum albumin Binding (binding) of associated with inflammation and cinod
16) Confidence 0.48 Published 1997 Journal J Pharm Biomed Anal Section Title Doc Link 9408837 Disease Relevance 0.19 Pain Relevance 0.19
Protein binding of drugs bound to albumin is not dramatically changed in obesity.
albumin Binding (bound) of associated with obesity
17) Confidence 0.48 Published 1986 Journal Clin Pharmacokinet Section Abstract Doc Link 3524955 Disease Relevance 0.72 Pain Relevance 0.19
Sulfa-drugs, antibiotics, steroidal agents, warfarine, tolubutamide and phenytoin showed no significant effects on the bilirubin-serum albumin interaction.
serum albumin Neg (no) Binding (interaction) of
18) Confidence 0.48 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6714852 Disease Relevance 0.08 Pain Relevance 0.08
Non-steroidal anti-inflammatory drugs, fenamates and allylphenyl propionic acids, affected the bilirubin-serum albumin interaction.
serum albumin Binding (interaction) of associated with inflammation and cinod
19) Confidence 0.48 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6714852 Disease Relevance 0.10 Pain Relevance 0.10
The fluorescence quenching method may be useful to evaluate the interaction of drug-bilirubin-serum albumin.
serum albumin Binding (interaction) of
20) Confidence 0.48 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6714852 Disease Relevance 0.08 Pain Relevance 0.08

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