INT5460

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Context Info
Confidence 0.23
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.18
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDAR) cell differentiation (EDAR) signal transduction (EDAR)
plasma membrane (EDAR)
Anatomy Link Frequency
monocytes 2
plasma 1
EDAR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
anesthesia 5 98.92 Very High Very High Very High
halothane 11 98.70 Very High Very High Very High
lidocaine 5 98.22 Very High Very High Very High
agonist 6 96.82 Very High Very High Very High
Opioid 19 81.08 Quite High
antagonist 7 75.00 Quite High
addiction 1 74.48 Quite High
sodium channel 1 69.84 Quite High
MU agonist 1 68.60 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 2 864 100.00 Very High Very High Very High
Diabetes Mellitus 348 99.98 Very High Very High Very High
Hyperglycemia 18 98.52 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 97.80 Very High Very High Very High
Acidosis 2 97.16 Very High Very High Very High
Shock 3 87.68 High High
Alkalosis 1 84.48 Quite High
Dyspnea 1 81.84 Quite High
Stress Incontinence 12 81.20 Quite High
Natriuresis 6 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The age differences among identified peptides were dominated by a general upregulation between ed12 and ed17 (Figure 1B, Table 2).
Positive_regulation (upregulation) of ed12
1) Confidence 0.23 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0.03
Pressor dose-response curves to the selective alpha 1-adrenergic agonist, phenylephrine, were constructed in groups of rabbits before, during and 2 hr after halothane anesthesia and the dose of phenylephrine that induced a 25 torr increase in mean arterial pressure (ED25) was derived by polynomial regression analysis.
Positive_regulation (increase) of ED25 associated with anesthesia, agonist and halothane
2) Confidence 0.23 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 2981487 Disease Relevance 0 Pain Relevance 0.71
The age differences among identified peptides were dominated by a general upregulation between ed12 and ed17 (Figure 1B, Table 2).
Positive_regulation (upregulation) of ed17
3) Confidence 0.20 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0.03
After 10 weeks of daily morphine administration (chronic phase), the average ED90 for morphine was increased 1 log unit.
Positive_regulation (increased) of ED90 associated with morphine
4) Confidence 0.18 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1309877 Disease Relevance 0.25 Pain Relevance 1.38
Endothelin levels in plasma are elevated in the diabetic state in experimental animal models of both Type I and Type II diabetes and the pathways it regulates are also up-regulated.[28] The up-regulation of ET-1 and the genes that it regulates could potentially result in ED because of an increase in cavernossal SM tone.
Positive_regulation (result) of ED in plasma associated with reprotox - general 2 and diabetes mellitus
5) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.91 Pain Relevance 0
The identification of Vcsa1 as a potential marker for ED was based on preliminary studies described above in which microarray analysis of gene expression in an animal model for ED resulting from radical prostatectomy suggested that one of the most down-regulated genes in the corpora of these animals was Vcsa1.[21] Our group in preliminary studies using microarray also demonstrated that Vcsa1 was one of the most down-regulated genes in an animal model for diabetes-induced ED.
Positive_regulation (induced) of ED associated with reprotox - general 2 and diabetes mellitus
6) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.03 Pain Relevance 0.08
Genes that are directly involved in erectile function are more likely to be specific for a particular etiology causing ED.
Positive_regulation (causing) of ED associated with reprotox - general 2
7) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.15 Pain Relevance 0
The basis of this assay is that diabetes-induced ED is caused by damage to endothelial cells from hyperglycemia and dyslipidemia and similar conditions activate monocytes to produce reactive oxygen species (ROS).
Positive_regulation (caused) of ED in monocytes associated with hyperglycemia, reprotox - general 2 and diabetes mellitus
8) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.46 Pain Relevance 0
The basis of this assay is that diabetes-induced ED is caused by damage to endothelial cells from hyperglycemia and dyslipidemia and similar conditions activate monocytes to produce reactive oxygen species (ROS).
Positive_regulation (induced) of ED in monocytes associated with hyperglycemia, reprotox - general 2 and diabetes mellitus
9) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.45 Pain Relevance 0
One of these would be that it is changed in all types of etiologies causing ED.
Positive_regulation (causing) of ED associated with reprotox - general 2
10) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.39 Pain Relevance 0
Lidocaine infusion to therapeutic levels (4.2 +/- .07 micrograms/ml) at normal pH (7.42 +/- 0.02) increased ED90 from 13 +/- 3 to 17 +/- 3 J (n = 6, p less than 0.05), and subsequent acidosis (pH 7.19 +/- 0.02, p less than 0.01) exacerbated this effect of lidocaine on ED90 (22 +/- 5 J, p less than 0.05).
Positive_regulation (increased) of ED90 associated with acidosis and lidocaine
11) Confidence 0.01 Published 1989 Journal Circulation Section Abstract Doc Link 2791234 Disease Relevance 0.35 Pain Relevance 0.48

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