INT54602

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 10.41
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCs 2
blood 1
MCS 1
temporal lobe 1
MCS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 2 100.00 Very High Very High Very High
Neuropathic pain 6 99.48 Very High Very High Very High
depression 279 98.96 Very High Very High Very High
nud 1 97.84 Very High Very High Very High
Thalamus 4 97.68 Very High Very High Very High
alcohol 30 97.60 Very High Very High Very High
spastic colon 4 96.12 Very High Very High Very High
Anterior cingulate 2 95.48 Very High Very High Very High
antidepressant 78 94.88 High High
backache 8 94.32 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.48 Very High Very High Very High
Cancer 62 99.40 Very High Very High Very High
Mental Disorders 88 99.34 Very High Very High Very High
Depression 351 98.96 Very High Very High Very High
Dyspepsia 1 97.84 Very High Very High Very High
Functional Bowel Disorder 4 96.12 Very High Very High Very High
Sprains And Strains 42 95.20 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 95.08 Very High Very High Very High
Low Back Pain 26 94.32 High High
Urological Neuroanatomy 1 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One could speculate that the cardiac MCs are responsible for these changes due to degranulation after exposure to EMFs.
Regulation (responsible) of MCs in MCs
1) Confidence 0.24 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10859662 Disease Relevance 0.91 Pain Relevance 0.19
The efficacy of MCS was mainly related to increased synaptic activity in the thalamus, whereas the activations in the rectus gyrus, anterior cingulate gyrus, and superior frontal cortex as well as the inactivation of the superior temporal lobe may be related to emotional processes.
Regulation (efficacy) of MCS in temporal lobe associated with urological neuroanatomy, thalamus and anterior cingulate
2) Confidence 0.23 Published 2004 Journal J. Neurosurg. Section Abstract Doc Link 15137612 Disease Relevance 0.35 Pain Relevance 0.71
Studies with a better design are mandatory to confirm the efficacy of MCS for chronic neuropathic pain.
Regulation (efficacy) of MCS associated with neuropathic pain
3) Confidence 0.23 Published 2009 Journal J. Neurosurg. Section Abstract Doc Link 18991496 Disease Relevance 0.73 Pain Relevance 0.48
These cases are discussed and the recent literature on MCS is reviewed in an attempt to identify indications for MCS as well as key structures in the brain for mediating the MCS effect.
Regulation (effect) of MCS in MCS
4) Confidence 0.23 Published 2003 Journal Neurol. Res. Section Abstract Doc Link 12635515 Disease Relevance 0.80 Pain Relevance 0.78
OBJECTIVE: To investigate the changes of the mast cells (MCs) and substance P (SP), and to elucidate their possible roles in visceral hypersensitivity in patients with irritable bowel syndrome (IBS).
Spec (investigate) Regulation (changes) of MCs in MCs associated with spastic colon, nud and substance p
5) Confidence 0.21 Published 2003 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 14514386 Disease Relevance 0.27 Pain Relevance 0.31
A one point change in PTT corresponded to a 0.15 (CI: 0.11–0.19) change in MCS score.
Regulation (change) of MCS
6) Confidence 0.19 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.23 Pain Relevance 0
Internalizing behavior symptoms were associated with only a small effect on caregiver's MCS score, again with wide confidence intervals around the beta coefficients for both samples.
Regulation (effect) of MCS
7) Confidence 0.19 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.34 Pain Relevance 0
To avoid the effects on image texture caused by the characteristics of the ultrasound image system, all mCS values obtained from the interventricular septum will be normalized for blood echoreflectivity (black = 255), assessed along the same axis inside the left ventricle, in each single patient (Figure 1).


Regulation (values) of mCS in blood
8) Confidence 0.08 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.05 Pain Relevance 0
On the MCS scale, quality of life was affected by history of cancer and depression, as well as by gender, alcohol use, and lack of physical activity.
Regulation (affected) of MCS associated with depression, cancer and alcohol
9) Confidence 0.08 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.29 Pain Relevance 0.10
In addition, women and men differed in how these factors influenced the PCS and MCS scores.
Regulation (influenced) of MCS
10) Confidence 0.06 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.28 Pain Relevance 0.10
The GMM has identified a larger proportion of the patient population who experience rapid and continued improvement in PCS and MCS scores over time.
Regulation (improvement) of MCS
11) Confidence 0.05 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1560373 Disease Relevance 0.05 Pain Relevance 0.04
According to the clinical or radiological diagnosis (CAT, MRI and/or myelography) conventional needle EMG was capable to localise the root lesion in 16 of 20 patients (80%) and ES localised the root involvement in 18 of 20 patients (90%); the diagnostic value of MCS was lower, about 65% (13 of 20 patients).
Regulation (value) of MCS
12) Confidence 0.05 Published 1994 Journal Clin Neurol Neurosurg Section Abstract Doc Link 7924074 Disease Relevance 0.16 Pain Relevance 0.28
Lastly, during our observation period, patients did not reach the general population average of 50 for the SF-36 MCS (MCS mean value at 6 months = 39.3).
Regulation (value) of SF-36 MCS
13) Confidence 0.04 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2923127 Disease Relevance 0.31 Pain Relevance 0.38
Strong validity was particularly evident in the known groups validity test with reported physical and mental health conditions having a significant effect on PCS and MCS scores.
Regulation (effect) of MCS associated with mental disorders
14) Confidence 0.04 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2612648 Disease Relevance 0.66 Pain Relevance 0.08
Lastly, during our observation period, patients did not reach the general population average of 50 for the SF-36 MCS (MCS mean value at 6 months = 39.3).
Regulation (value) of MCS
15) Confidence 0.04 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2923127 Disease Relevance 0.31 Pain Relevance 0.38
To control for HRQL, the total scores on the PCS and MCS were entered first.
Regulation (control) of MCS
16) Confidence 0.03 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2993679 Disease Relevance 0.33 Pain Relevance 0.05
Multiple logistic regression was performed using two different models to verify the influence on MCS and PCS, respectively, of socio-demographic, lifestyle, social network, geographical area and health care service access/use as independent variables; all explicatory variables were taken as models.
Regulation (influence) of MCS
17) Confidence 0.02 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2569037 Disease Relevance 0.95 Pain Relevance 0.13
For ease of interpretation of Table 3 data, estimated predicted values of HAQ, PCS, MCS and EQ-5D are presented at time points of -10 and +10 years, based on adjusted regression analyses.


Regulation (values) of MCS
18) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888182 Disease Relevance 0.19 Pain Relevance 0.07
When only patients never treated with biologics were considered (Table 2) HAQ scores worsened by 0.016 per year (95% CI 0.013, 0.019), but no significant changes were seen for PCS, MCS, or EQ-5D.
Neg (no) Regulation (changes) of MCS
19) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888182 Disease Relevance 0.29 Pain Relevance 0.07
Separate models were developed for change in the SF-36 PCS and SF-36 MCS.
Regulation (change) of MCS
20) Confidence 0.02 Published 2010 Journal Arthritis Care & Research Section Body Doc Link PMC2909400 Disease Relevance 0.32 Pain Relevance 0.04

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