INT54615

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 8.23
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GPER) endoplasmic reticulum (GPER) plasma membrane (GPER)
signal transducer activity (GPER)
Anatomy Link Frequency
Th2 cells 4
neutrophils 3
MDA-MB-231 2
eye 1
renal artery 1
GPER (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
Inflammation 192 99.04 Very High Very High Very High
aspirin 2 96.08 Very High Very High Very High
agonist 34 95.28 Very High Very High Very High
anesthesia 26 94.88 High High
Dopamine 12 89.52 High High
antagonist 6 88.00 High High
antidepressant 2 86.64 High High
Pain 2 85.56 High High
Inflammatory response 20 82.84 Quite High
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 91 100.00 Very High Very High Very High
Xerostomia 1 100.00 Very High Very High Very High
INFLAMMATION 213 99.04 Very High Very High Very High
Adhesions 173 98.60 Very High Very High Very High
Hypersensitivity 36 97.74 Very High Very High Very High
Hodgkin's Disease 25 96.72 Very High Very High Very High
Disease 77 95.92 Very High Very High Very High
Breast Cancer 16 93.64 High High
Volume Depletion And Dehydration 1 88.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection and siRNA-silencing of GPR30 expression resulted in corresponding changes in GPR30 protein expression but only internally, and the response to E2 was not affected.
Gene_expression (expression) of GPR30
1) Confidence 0.75 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20432453 Disease Relevance 0.37 Pain Relevance 0.15
Expression of GPR30 (a G-protein-coupled estrogen receptor) in MDA-MB-231 cells was confirmed by PCR, Western blot and immunocytochemistry.
Gene_expression (Expression) of GPR30 in MDA-MB-231
2) Confidence 0.75 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20432453 Disease Relevance 0.34 Pain Relevance 0.04
Transfection and siRNA-silencing of GPR30 expression resulted in corresponding changes in GPR30 protein expression but only internally, and the response to E2 was not affected.
Gene_expression (expression) of GPR30
3) Confidence 0.75 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20432453 Disease Relevance 0.37 Pain Relevance 0.05
Expression of GPR30 (a G-protein-coupled estrogen receptor) in MDA-MB-231 cells was confirmed by PCR, Western blot and immunocytochemistry.
Gene_expression (Expression) of G-protein-coupled estrogen receptor in MDA-MB-231
4) Confidence 0.75 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20432453 Disease Relevance 0.34 Pain Relevance 0.05
We determined that GPER RNA and protein are expressed in PC12 cells,58,103,110 where a recently developed GPER-selective ligand111 appears to have inhibitory effects on ER?
Gene_expression (expressed) of GPER
5) Confidence 0.52 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.07 Pain Relevance 0.12
We then used the L2L Microarray Analysis Tool [53] to search for expression patterns among these MER85-associated genes (Table S5).
Gene_expression (expression) of MER85
6) Confidence 0.22 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.09 Pain Relevance 0
Analysis of MER-Associated Genes
Gene_expression (Analysis) of MER
7) Confidence 0.22 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.09 Pain Relevance 0
Chemoattractant receptor-homologous molecule expressed on T helper 2 cells (CRTH2) has attracted interest as a potential therapeutic target in inflammatory diseases.
Gene_expression (expressed) of Chemoattractant receptor-homologous molecule associated with inflammation and disease
8) Confidence 0.14 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16418339 Disease Relevance 0.28 Pain Relevance 0.13
Pharmacology of the Tripeptide D-PHE-D-GLU-GLY (feG)
Gene_expression (Pharmacology) of feG
9) Confidence 0.07 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.35 Pain Relevance 0.17
Since feG was synthesized based on the sequence of a rat peptide [5], but has potent activities on human neutrophils, we also examined the effects of this peptide on circulating rat neutrophils. feG at concentrations from 10-11M to 10-10M inhibited the binding of CD11b antibody to rat neutrophils (Figure 8).
Gene_expression (synthesized) of feG in neutrophils
10) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.05 Pain Relevance 0
Core Laboratories, Queens University, Kingston, ON synthesized feG.
Gene_expression (synthesized) of feG
11) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.17 Pain Relevance 0
In the dose ranges of 10-8M to 10-12M feG superoxide production remained unchanged (54.1 ± 6.7 ?
Gene_expression (production) of feG
12) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.61 Pain Relevance 0
A second point related to feG's actions ??
Gene_expression (actions) of feG
13) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.21 Pain Relevance 0.10
Since feG affects CD11b and has no effect on CD11a, CD11c or CD18, it appears that the peptide affects predominately the binding of CD11b antibody rather than promoting a loss of this integrin from the cell.
Gene_expression (affects) of feG
14) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.23 Pain Relevance 0.08
Unlike NGF, which promotes numerous neutrophil functions, the actions of feG are limited to cell migration and adhesion, as superoxide production and phagocytosis were not affected.
Gene_expression (actions) of feG in neutrophil associated with adhesions
15) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.55 Pain Relevance 0.17
To investigate if a functional correlation exists between the effects of feG on CD11b and CD16 during an inflammation, these molecules were measured on blood and peritoneal neutrophils isolated from ovalbumin-sensitized rats that had been challenged with antigen after being treated with feG (100 ?
Gene_expression (effects) of feG in neutrophils associated with inflammation
16) Confidence 0.07 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.18 Pain Relevance 0.05
Improvements in lung function with NVA237 seem to be comparable to those observed with tiotropium [34] but inhaled NVA237 does not produce the dry mouth side effect that is often reported with other antimuscarinic drugs.
Neg (not) Gene_expression (produce) of dry in mouth associated with xerostomia
17) Confidence 0.06 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2682927 Disease Relevance 0.17 Pain Relevance 0.03
PGD2 mediates allergic and inflammatory reactions through two distinct types of receptors: the D-type prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2).
Gene_expression (expressed) of chemoattractant receptor-homologous molecule in Th2 cells associated with inflammation and hypersensitivity
18) Confidence 0.05 Published 2011 Journal Journal of Synchrotron Radiation Section Body Doc Link PMC3004263 Disease Relevance 0.61 Pain Relevance 0.26
PGD2 exerts its effects principally by binding and activating two plasma membrane receptors, the D prostanoid receptor (DP) 1 [15] and chemoattractant-receptor-like molecule expressed on Th2 cells (CRTH2), also known as DP2 [16].
Gene_expression (expressed) of chemoattractant-receptor-like molecule in Th2 cells
19) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.09 Pain Relevance 0.37
Prostaglandin (PG) D2 is a lipid mediator related to immunity and inflammation through the activation of two types of receptors, the D-­type prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), and is known to cause contractions in smooth muscle in the airway via DP and to mediate the chemotaxis of eosinophils and basophils into the lung via CRTH2 (Matsuoka et al., 2000 ?
Gene_expression (expressed) of chemoattractant receptor-homologous molecule in Th2 cells associated with inflammation
20) Confidence 0.04 Published 2010 Journal Acta Crystallographica Section F: Structural Biology and Crystallization Communications Section Body Doc Link PMC2898477 Disease Relevance 0.16 Pain Relevance 0.14

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