INT54617

Context Info Confidence 0.67 First Reported 1994 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 22 Total Number 24 Disease Relevance 9.80 Pain Relevance 5.34

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b) transmembrane transport (Abcb1b)

Anatomy Link Frequency CSCs 12 4T1 2 brain 2 syncytiotrophoblast 2 L1210 2 Abcb1b (Mus musculus)

Pain Link Frequency Relevance Heat cocaine 32 100.00 Oxycodone 36 99.98 vincristine 7 99.70 Morphine 20 99.62 Cancer pain 2 96.92 Opioid 4 96.48 MU agonist 4 93.16 methadone 78 89.44 addiction 2 56.76 opiate 4 56.36

Disease Link Frequency Relevance Heat Cancer 944 98.36 Sprains And Strains 100 98.16 Cancer Pain 2 96.92 Advanced Or Metastatic Breast Cancer 138 95.12 Recurrence 40 93.52 Breast Cancer 495 86.16 Non-small-cell Lung Cancer 4 85.16 Myeloid Leukemia 141 69.76 Malignant Neoplastic Disease 32 67.52 Opiate Addiction 4 56.76

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This cell line was obtained by long-term adaptation of the L1210 mouse leukaemic cell line on vincristine and showed an overexpression of P-glycoprotein and accompanying multidrug resistance (MDR) which was defined as a cell resistance to several cytostatics such as vincristine, vinblastine and actinomycin D.

Positive_regulation (overexpression) of Gene_expression (overexpression) of P-glycoprotein in L1210 associated with vincristine

1) Confidence 0.67 Published 1994 Journal Drugs Exp Clin Res Section Abstract Doc Link 7924890 Disease Relevance 0 Pain Relevance 0.23

One important factor in the development of MDR is overexpression of P-glycoprotein, encoded by the MDR1 gene.

Positive_regulation (overexpression) of Gene_expression (overexpression) of P-glycoprotein

2) Confidence 0.67 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.33 Pain Relevance 0.58

Recently, morphine has been shown to induce P-glycoprotein expression in the rat brain.

Positive_regulation (induce) of Gene_expression (expression) of P-glycoprotein in brain associated with morphine

3) Confidence 0.67 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.35 Pain Relevance 0.74

Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

Positive_regulation (overexpression) of Gene_expression (overexpression) of P-glycoprotein associated with oxycodone

4) Confidence 0.67 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64

Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

Positive_regulation (induces) of Gene_expression (overexpression) of P-glycoprotein associated with oxycodone

5) Confidence 0.67 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64

Although it is uncertain whether selection of the mdr1 duplication and its consequent overexpression was driven by ATN, MF, or both, this result is similar to a number previous studies suggesting a role for this gene in resistance to aminoquinolines and artemisinin derivatives [19], [21], [22], [24], [30], [34].

Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of mdr1

6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0

Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

Positive_regulation (induces) of Gene_expression (overexpression) of ABCB1 associated with oxycodone

7) Confidence 0.49 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64

Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.

Positive_regulation (overexpression) of Gene_expression (overexpression) of ABCB1 associated with oxycodone

8) Confidence 0.49 Published 2007 Journal J Pharm Sci Section Title Doc Link 17593551 Disease Relevance 0 Pain Relevance 0.64

One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].

Positive_regulation (resistance) of Gene_expression (expression) of P-glycoprotein in CSCs

9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.30 Pain Relevance 0

One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].

Positive_regulation (resistance) of Gene_expression (expression) of P-glycoprotein in CSCs

10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.30 Pain Relevance 0

Microparticles (MPs) released from syncytiotrophoblast into maternal circuit increased by 30% after cocaine or heroin (P < 0.05) and the expression of P-glycoprotein in the tissue increased by ?

Positive_regulation (increased) of Gene_expression (expression) of P-glycoprotein in syncytiotrophoblast associated with cocaine

11) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2703629 Disease Relevance 0.06 Pain Relevance 1.19

Epothilones are poor substrates for P-glycoprotein and are cytotoxic in cell lines that express high levels of P-glycoprotein (Lehne 2000).

Positive_regulation (levels) of Gene_expression (express) of P-glycoprotein

12) Confidence 0.45 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.22 Pain Relevance 0.03

Other mechanisms of imatinib resistance may include: increased expression of Bcr-Abl through genomic amplification (Nicolini et al 2006), overexpression of Lyn or other Src-family tyrosine kinases (Donato et al 2003; Dai et al 2004), or overexpression of drug efflux proteins such as P-glycoprotein, which may decrease the intracellular concentration of imatinib in leukemic cells (Thomas et al 2004).

Positive_regulation (overexpression) of Gene_expression (overexpression) of as P-glycoprotein

13) Confidence 0.45 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761189 Disease Relevance 0.13 Pain Relevance 0

Doxorubicin treatment showed enhanced MDR1 expression in a dose dependent manner as detected by Western blotting (Figure 4C).

Positive_regulation (enhanced) of Gene_expression (expression) of MDR1

14) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.25 Pain Relevance 0

1 treatment increased MDR1 expression in 4T1 cells which was detected by both flow cytometry (Figure 4A) and western blotting (Figure 4C), we also tested whether TGF?

Positive_regulation (increased) of Gene_expression (expression) of MDR1 in 4T1

15) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.32 Pain Relevance 0

MDR1 protein levels are increased in AS-ATNMF1

Positive_regulation (increased) of Gene_expression (levels) of MDR1

16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0

There is thus a disproportionate increase in the expression of MDR1 protein relative to gene copy number in the resistant parasites (Table 1).

Positive_regulation (increase) of Gene_expression (expression) of MDR1

17) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0

This is mediated by an increased expression at the cell surface of the ABCB1 gene product, P-glycoprotein, an energy dependent efflux pump, which reduces intracellular drug concentrations and leads to ineffective levels of the drug reaching its target.79 Imatinib is a substrate of ABCB1, and the intracellular levels of imatinib were shown to be significantly lower in ABCB1-expressing cells.65,80–82 However, ABCB1 overexpression has not been reported in patients who are resistant to imatinib.

Positive_regulation (overexpression) of Gene_expression (overexpression) of ABCB1

18) Confidence 0.34 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.29 Pain Relevance 0

or doxorubicin increased the number of 4T1 cells expressing stem cell marker Sca-1 and the drug resistant transporter protein MDR1, and with the stem cell property of self-renewal as indicated by mammosphere formation.

Positive_regulation (increased) of Gene_expression (expressing) of MDR1 in stem cell

19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.84 Pain Relevance 0

One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].

Positive_regulation (resistance) of Gene_expression (/) of ABCB1 in CSCs

20) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.29 Pain Relevance 0

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