INT54617
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
This cell line was obtained by long-term adaptation of the L1210 mouse leukaemic cell line on vincristine and showed an overexpression of P-glycoprotein and accompanying multidrug resistance (MDR) which was defined as a cell resistance to several cytostatics such as vincristine, vinblastine and actinomycin D. | |||||||||||||||
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One important factor in the development of MDR is overexpression of P-glycoprotein, encoded by the MDR1 gene. | |||||||||||||||
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Recently, morphine has been shown to induce P-glycoprotein expression in the rat brain. | |||||||||||||||
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Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. | |||||||||||||||
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Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. | |||||||||||||||
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Although it is uncertain whether selection of the mdr1 duplication and its consequent overexpression was driven by ATN, MF, or both, this result is similar to a number previous studies suggesting a role for this gene in resistance to aminoquinolines and artemisinin derivatives [19], [21], [22], [24], [30], [34]. | |||||||||||||||
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Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. | |||||||||||||||
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Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. | |||||||||||||||
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One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38]. | |||||||||||||||
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One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38]. | |||||||||||||||
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Microparticles (MPs) released from syncytiotrophoblast into maternal circuit increased by 30% after cocaine or heroin (P < 0.05) and the expression of P-glycoprotein in the tissue increased by ? | |||||||||||||||
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Epothilones are poor substrates for P-glycoprotein and are cytotoxic in cell lines that express high levels of P-glycoprotein (Lehne 2000). | |||||||||||||||
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Other mechanisms of imatinib resistance may include: increased expression of Bcr-Abl through genomic amplification (Nicolini et al 2006), overexpression of Lyn or other Src-family tyrosine kinases (Donato et al 2003; Dai et al 2004), or overexpression of drug efflux proteins such as P-glycoprotein, which may decrease the intracellular concentration of imatinib in leukemic cells (Thomas et al 2004). | |||||||||||||||
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Doxorubicin treatment showed enhanced MDR1 expression in a dose dependent manner as detected by Western blotting (Figure 4C). | |||||||||||||||
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1 treatment increased MDR1 expression in 4T1 cells which was detected by both flow cytometry (Figure 4A) and western blotting (Figure 4C), we also tested whether TGF? | |||||||||||||||
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MDR1 protein levels are increased in AS-ATNMF1 | |||||||||||||||
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There is thus a disproportionate increase in the expression of MDR1 protein relative to gene copy number in the resistant parasites (Table 1). | |||||||||||||||
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This is mediated by an increased expression at the cell surface of the ABCB1 gene product, P-glycoprotein, an energy dependent efflux pump, which reduces intracellular drug concentrations and leads to ineffective levels of the drug reaching its target.79 Imatinib is a substrate of ABCB1, and the intracellular levels of imatinib were shown to be significantly lower in ABCB1-expressing cells.65,8082 However, ABCB1 overexpression has not been reported in patients who are resistant to imatinib. | |||||||||||||||
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or doxorubicin increased the number of 4T1 cells expressing stem cell marker Sca-1 and the drug resistant transporter protein MDR1, and with the stem cell property of self-renewal as indicated by mammosphere formation. | |||||||||||||||
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One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38]. | |||||||||||||||
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General Comments
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