INT54619

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.68
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
muscles 3
plasma 2
blood 2
forelimb bone 1
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 116 100.00 Very High Very High Very High
cytokine 61 100.00 Very High Very High Very High
antagonist 10 99.98 Very High Very High Very High
Intracerebroventricular 3 98.60 Very High Very High Very High
Dopamine 36 96.72 Very High Very High Very High
Serotonin 16 95.92 Very High Very High Very High
Osteoarthritis 23 92.92 High High
Glutamate 42 91.20 High High
Hyperalgesia 77 90.52 High High
hyperexcitability 1 89.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 122 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 26 99.96 Very High Very High Very High
Heat Stroke 228 99.52 Very High Very High Very High
Arthritis 11 99.36 Very High Very High Very High
Hypersensitivity 4 98.56 Very High Very High Very High
Osteoarthritis 23 92.92 High High
Hyperalgesia 77 90.52 High High
Pain 27 87.60 High High
Stress 9 81.92 Quite High
Cv General 4 Under Development 48 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, anti-TNFalpha treatment attenuated task-induced increases in inflammatory cytokines (TNFalpha, IL-1alpha, and MIP2 in serum; TNFalpha in forelimb bone and muscles) and serum osteocalcin in 6-week HRHF animals.
Negative_regulation (attenuated) of Positive_regulation (increases) of IL-1alpha in muscles associated with inflammation and cytokine
1) Confidence 0.42 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.78 Pain Relevance 0.43
Intracerebroventricular, but not iv, administration of 2 micrograms IL-1 receptor antagonist blocked the IL-1 alpha-induced increase.
Negative_regulation (blocked) of Positive_regulation (increase) of IL-1 alpha associated with antagonist and intracerebroventricular
2) Confidence 0.42 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.16 Pain Relevance 0.47
Moreover, anti-TNFalpha treatment attenuated task-induced increases in inflammatory cytokines (TNFalpha, IL-1alpha, and MIP2 in serum; TNFalpha in forelimb bone and muscles) and serum osteocalcin in 6-week HRHF animals.
Negative_regulation (attenuated) of in forelimb bone Positive_regulation (increases) of IL-1alpha in muscles associated with inflammation and cytokine
3) Confidence 0.14 Published 2010 Journal J. Cell. Physiol. Section Abstract Doc Link 20458732 Disease Relevance 0.78 Pain Relevance 0.43
Our results here underscore the potential of IL-1?
Negative_regulation (underscore) of Positive_regulation (potential) of IL-1
4) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.51 Pain Relevance 0.28
Our results indicated that following heat stroke, arterial hypotension, decreased cerebral blood flow, increased serum levels of IL-1?
Negative_regulation (decreased) of Positive_regulation (increased) of IL-1 in blood associated with heat stroke and pressure volume 2 under development
5) Confidence 0.06 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 1.32 Pain Relevance 0.31
The immediate administration of this combined agent might exert its protective effects by attenuating the increased plasma level of IL-1?
Negative_regulation (attenuating) of Positive_regulation (increased) of IL-1 in plasma
6) Confidence 0.06 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 1.29 Pain Relevance 0.32
It is interesting that both glial inhibitors suppressed inflammation-induced IL-1?
Negative_regulation (suppressed) of Positive_regulation (induced) of IL-1 associated with inflammation
7) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.85 Pain Relevance 0.88

General Comments

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