INT54625

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.60
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.82 Very High Very High Very High
cytokine 6 89.36 High High
chemokine 1 75.92 Quite High
Inflammation 7 55.92 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 95.96 Very High Very High Very High
Toxicity 10 78.64 Quite High
INFLAMMATION 4 55.92 Quite High
Disease Progression 6 50.00 Quite Low
Pulmonary Emphysema 4 50.00 Quite Low
Sleep Disorders 1 7.56 Low Low
Emphysema 13 5.00 Very Low Very Low Very Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Pneumonia 5 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At concentrations of lobenzarit of 0.2 and 0.3 mM, added 30 min before paracetamol, the drug prevented paracetamol-induced leakage of lactate dehydrogenase (LDH) almost completely and lipid peroxidation (LPO) and depletion of glutathione (GSH) substantially and also the formation of the 3-glutathionyl conjugate of paracetamol.
Protein_catabolism (leakage) of LDH associated with paracetamol
1) Confidence 0.78 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.15 Pain Relevance 0.83
At concentrations of lobenzarit of 0.2 and 0.3 mM, added 30 min before paracetamol, the drug prevented paracetamol-induced leakage of lactate dehydrogenase (LDH) almost completely and lipid peroxidation (LPO) and depletion of glutathione (GSH) substantially and also the formation of the 3-glutathionyl conjugate of paracetamol.
Protein_catabolism (leakage) of lactate dehydrogenase associated with paracetamol
2) Confidence 0.78 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8748682 Disease Relevance 0.15 Pain Relevance 0.83
Valproate caused a dose-dependent increase in leakage of lactic acid dehydrogenase (LDH), and glycine prevented this toxic response.
Protein_catabolism (leakage) of LDH
3) Confidence 0.60 Published 1994 Journal Epilepsia Section Abstract Doc Link 7925144 Disease Relevance 0.24 Pain Relevance 0.06
ELT increased the levels of total protein, ALP, and LDH compared with the sham treatment (p<0.01 for total protein in the ELT 160 U group and LDH in the ELT 20 U and 160 U groups; p<0.05 for ALP in the ELT 160 U group).
Protein_catabolism (protein) of LDH
4) Confidence 0.41 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831096 Disease Relevance 0.06 Pain Relevance 0.18

General Comments

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