INT54632

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.22
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprd1) plasma membrane (Oprd1) cytoplasm (Oprd1)
signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 4
spinal cord 2
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 33 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Spinal cord 2 99.68 Very High Very High Very High
MU agonist 2 97.60 Very High Very High Very High
intrathecal 1 96.96 Very High Very High Very High
Kappa opioid receptor 5 93.12 High High
antinociception 4 90.40 High High
agonist 15 90.36 High High
Enkephalin 4 85.44 High High
midbrain 3 83.80 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 36 99.98 Very High Very High Very High
Injury 6 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure to hypoxia (9% oxygen, balance nitrogen) continuously for seven days selectively decreased delta opioid receptor expression in mouse brain homogenate.
Negative_regulation (decreased) of Gene_expression (expression) of delta opioid receptor in brain associated with hypoxia and opioid receptor
1) Confidence 0.58 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.40
Hypoxia decreases opioid delta receptor expression in mouse brain.
Negative_regulation (decreases) of Gene_expression (expression) of opioid delta receptor in brain associated with hypoxia and opioid
2) Confidence 0.51 Published 1996 Journal Neuroscience Section Title Doc Link 9157323 Disease Relevance 0.70 Pain Relevance 0.46
An antisense oligodeoxynucleotide (A-oligo) to delta-opioid receptor mRNA was utilized to block the expression of mouse delta-opioid receptor in the spinal cord of male ICR mice.
Negative_regulation (block) of Gene_expression (expression) of delta-opioid receptor in spinal cord associated with opioid receptor and spinal cord
3) Confidence 0.50 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7925585 Disease Relevance 0 Pain Relevance 0.89
One possible cause for the decrease in delta opioid receptor expression following seven days of hypoxic exposure may be receptor down-regulation caused by an increased release of endogenous substances acting at delta receptors.
Negative_regulation (decrease) of Gene_expression (expression) of delta opioid receptor associated with hypoxia and opioid receptor
4) Confidence 0.38 Published 1996 Journal Neuroscience Section Abstract Doc Link 9157323 Disease Relevance 0.82 Pain Relevance 0.59
[Inhibition of the expression of delta opioid receptor mRNA by long-term exposure of NG-108-15 cell line to delta opioid agonists].
Negative_regulation ([Inhibition) of Gene_expression (expression) of delta opioid receptor associated with mu agonist and opioid receptor
5) Confidence 0.07 Published 1998 Journal Sheng Li Xue Bao Section Title Doc Link 11324539 Disease Relevance 0 Pain Relevance 0.55

General Comments

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