INT5464

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Context Info
Confidence 0.16
First Reported 1984
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 4.20
Pain Relevance 11.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
plasma 1
nerves 1
lateral 1
immune system 1
neural 1
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 95 100.00 Very High Very High Very High
Calcitonin gene-related peptide 90 100.00 Very High Very High Very High
opioid receptor 79 100.00 Very High Very High Very High
gABA 34 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
nMDA receptor 5 100.00 Very High Very High Very High
agonist 160 99.88 Very High Very High Very High
Inflammation 50 99.68 Very High Very High Very High
Opioid 36 99.64 Very High Very High Very High
qutenza 8 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 4 100.00 Very High Very High Very High
INFLAMMATION 62 99.68 Very High Very High Very High
Headache 39 99.34 Very High Very High Very High
Pain 29 97.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 96.36 Very High Very High Very High
Nociception 7 95.08 Very High Very High Very High
Disease 14 93.04 High High
Inflammatory Pain 3 93.00 High High
Anxiety Disorder 8 89.52 High High
Bordatella Infection 24 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding affinities of the 5-HT antagonists ritanserin, GR 125743, and SB-224289 were not modified at either chimeric 5-HT receptor.
Neg (not) Regulation (modified) of receptor associated with antagonist
1) Confidence 0.16 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10704941 Disease Relevance 0 Pain Relevance 0.20
Opioid use and/or abuse during pregnancy affects placental receptor content at delivery, as well as its mediated functions.
Regulation (affects) of receptor associated with opioid
2) Confidence 0.14 Published 1992 Journal Life Sci. Section Abstract Doc Link 1309934 Disease Relevance 0 Pain Relevance 0.69
CGRP can induce migraine attacks, and two selective CGRP receptor antagonists are effective in the treatment of migraine attacks.
Regulation (effective) of receptor associated with antagonist, migraine and calcitonin gene-related peptide
3) Confidence 0.10 Published 2008 Journal J Headache Pain Section Abstract Doc Link PMC2386847 Disease Relevance 0.51 Pain Relevance 0.96
Certain 5-HT(2C) receptor antagonists may possess negative efficacy at 5-HT(2C) receptors and, as inverse agonists, may control constitutive receptor activity possibly characterising some psychopathological states.
Regulation (control) of receptor associated with antagonist and agonist
4) Confidence 0.08 Published 1998 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15991903 Disease Relevance 0.76 Pain Relevance 0.49
The effects of Met-enkephalin (Met-Enk), a delta receptor binding opioid peptide, and its more stable synthetic analogs, Tyr-D-Ala-Gly-MePhe-Met-NHC3H7-iso (1), Tyr-D-Ala-Gly-MePhe-Gly-NHC3H7-iso (2) and Tyr-D-Ala-Gly-MePhe-Gly-NHCH2C6H5 (3), on human T-cell transformation and natural killer (NK) cell cytotoxicity have been evaluated.
Regulation (effects) of receptor in T-cell associated with enkephalin and opioid
5) Confidence 0.05 Published 1995 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7558515 Disease Relevance 0 Pain Relevance 0.27
The alpha and gamma subunit subtypes may have the greatest influence on allopregnanolone modulation of GABA(A) receptor function, whereas the beta and gamma subunit subtypes appear to be most important for the modulatory effects of alphaxalone.
Regulation (modulation) of ) receptor associated with gaba
6) Confidence 0.04 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10066142 Disease Relevance 0 Pain Relevance 0.29
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
Regulation (Modulation) of ) receptor associated with gaba
7) Confidence 0.04 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 10066142 Disease Relevance 0.09 Pain Relevance 0.45
Reliable ESTs can be recovered from neural tissues for the PTGER homolog (ci0100153844) suggesting that these receptor homologs are involved in neural tissue physiology [Additional data file 2: sheet 2].
Regulation (involved) of receptor in neural
8) Confidence 0.02 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.09 Pain Relevance 0.25
While the B(2)receptor subtype, constitutively expressed in various tissues, is believed to mediate most of the physiological actions of kinins in healthy conditions, the B(1) receptor, highly regulated during inflammation, has been associated with the sustained actions of these peptides in various pathological situations.
Regulation (regulated) of receptor associated with inflammation
9) Confidence 0.02 Published 2006 Journal Curr Top Med Chem Section Abstract Doc Link 16918454 Disease Relevance 0.23 Pain Relevance 0.22
Hence, the micro-opioid receptor G-protein coupling efficacy in SII of carriers of the 118G variant was only 58% as efficient as in homozygous carriers of the 118A allele (p<0.001).
Regulation (efficacy) of receptor associated with opioid receptor
10) Confidence 0.01 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19116204 Disease Relevance 0.29 Pain Relevance 0.85
For AVP there was lack of such correlation which may suggest that this hormone influences both the OT and AVP V1a receptor sites.
Regulation (influences) of receptor
11) Confidence 0.01 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8714023 Disease Relevance 0.16 Pain Relevance 0.24
Several publications then showed that other neurotransmitter receptors, such as GABAA receptors (Bogdanov et al., 2006) and ionotropic glutamate receptors (Borgdorff and Choquet, 2002), are also mobile within the neuronal plasma membrane, providing a basis for dynamic activity-dependent regulation of postsynaptic receptor numbers.
Regulation (regulation) of receptor in plasma associated with neurotransmitter and glutamate receptor
12) Confidence 0.01 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0 Pain Relevance 0.33
We show that the main effect of the N40D micro-opioid receptor variant is a reduction of the agonist-induced receptor signaling efficacy.
Regulation (efficacy) of receptor associated with agonist and opioid receptor
13) Confidence 0.01 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19116204 Disease Relevance 0.33 Pain Relevance 0.85
These findings suggest the involvement of tachykinin NK2, CGRP and non-NMDA receptor systems in the vanilloid VR1 receptor-mediated regulation of gastric acid secretion in the rat brain regions close to the lateral cerebroventricle.
Regulation (involvement) of receptor in lateral associated with nmda receptor and calcitonin gene-related peptide
14) Confidence 0.01 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.58
Opioid receptor levels are regulated by peripheral inflammation [2], and it is thought that highly peripherally selective opioid agonists may provide a therapeutic approach for the treatment of inflammation and inflammatory pain (see [3] for review).
Regulation (regulated) of receptor associated with mu agonist, inflammation, ipn and opioid receptor
15) Confidence 0.01 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.39 Pain Relevance 0.61
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Opioid agonists have a broad range of effects on cells of the immune system, including modulation of the inflammatory response, and opioid and chemokine receptors are co-expressed by many white cells.

Regulation (regulation) of receptor in immune system associated with chemokine, inflammatory response, mu agonist, opioid receptor and opioid
16) Confidence 0.01 Published 2008 Journal Biochemical Journal Section Title Doc Link PMC2474558 Disease Relevance 0.10 Pain Relevance 0.87
Although a highly effective means to explore these receptor co-expression-dependent heterodimer-specific [25,44] allosteric effects of CXCR2 antagonists on DOP receptor function, the fusion proteins are artificial constructions [45,46].
Regulation (effects) of receptor associated with antagonist
17) Confidence 0.01 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.08 Pain Relevance 0.05
Therefore, pharmacological agents that target this receptor may potentially have clinical utility as anti-inflammatory and analgesic therapy.
Regulation (target) of receptor associated with inflammation and analgesic
18) Confidence 0.00 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18772321 Disease Relevance 0.44 Pain Relevance 0.49
Furthermore, the allosteric enhancer would enhance the action of the native agonist, but may have no effect of its own on the unoccupied receptor.
Neg (no) Regulation (effect) of receptor associated with agonist
19) Confidence 0.00 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0.09 Pain Relevance 0.37
Thus, analogous to the findings for the role of opioid receptors in analgesia, it appears that multiple opioid receptors may be involved in appetite regulation, each receptor relating to a different aspect of feeding.
Regulation (regulation) of receptor associated with appetite loss, opioid receptor and analgesia
20) Confidence 0.00 Published 1984 Journal Appetite Section Abstract Doc Link 6148913 Disease Relevance 0.32 Pain Relevance 0.68

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