INT5465

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 7.24
Pain Relevance 9.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
Thyroid 1
uterus 1
cleavage 1
platelet 1
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 50 100.00 Very High Very High Very High
gABA 37 100.00 Very High Very High Very High
Glutamate receptor 25 100.00 Very High Very High Very High
Neurotransmitter 25 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
Morphine 71 99.84 Very High Very High Very High
anticonvulsant 1 99.60 Very High Very High Very High
Cannabinoid receptor 6 99.40 Very High Very High Very High
withdrawal 39 99.26 Very High Very High Very High
mu opioid receptor 51 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 191 99.44 Very High Very High Very High
Substance Withdrawal Syndrome 3 99.44 Very High Very High Very High
Colon Cancer 44 99.28 Very High Very High Very High
Gastrointestinal Stromal Tumor 5 99.26 Very High Very High Very High
Anxiety Disorder 11 99.22 Very High Very High Very High
Leukemia 6 99.08 Very High Very High Very High
Alcohol Addiction 29 97.92 Very High Very High Very High
Thyroid Neoplasm 169 96.84 Very High Very High Very High
Heart Rate Under Development 8 94.04 High High
Fever 1 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, using RT-PCR, we could demonstrate the presence of mRNAs encoding for several 5-HT receptors (5-HT(1B), 5-HT(1D), 5-HT(1F), 5-HT(2A) and 5-HT(7)) and adrenoceptors (alpha(1A), alpha(1B), alpha(1D), alpha(2A), alpha(2B), alpha(2C), beta(1) and beta(2)), as well as that for the calcitonin receptor like receptor, a component of the CGRP(1) receptor.
Positive_regulation (demonstrate) of calcitonin receptor like receptor
1) Confidence 0.49 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17103145 Disease Relevance 0.36 Pain Relevance 0.55
The results of ongoing clinical studies on the effect of the partial GABA(A) agonist THIP on human sleep pattern show that the functional consequences of a directly acting agonist are distinctly different from those seen after administration of GABA(A) receptor modulators, such as benzodiazepines.
Positive_regulation (administration) of ) receptor associated with gaba and agonist
2) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451401 Disease Relevance 0 Pain Relevance 1.18
Calcitonin gene-related peptide (CGRP) is an endogenous vasodilator peptide that produces its effects by activation of CGRP1 and CGRP2 receptor subtypes.
Positive_regulation (activation) of CGRP2 receptor associated with calcitonin gene-related peptide
3) Confidence 0.29 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336535 Disease Relevance 0 Pain Relevance 0.40
Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion.
Positive_regulation (Induction) of receptor
4) Confidence 0.27 Published 2000 Journal Biochem. Pharmacol. Section Title Doc Link 10704941 Disease Relevance 0 Pain Relevance 0.11
Two opioid receptor mediated functions were identified in trophoblast tissue, namely regulation of acetylcholine and hormonal (human chorionic gonadotrophin and human placental lactogen) release.
Positive_regulation (mediated) of receptor associated with opioid receptor
5) Confidence 0.24 Published 1992 Journal Life Sci. Section Abstract Doc Link 1309934 Disease Relevance 0 Pain Relevance 0.48
Allopregnanolone is a neurosteroid which exhibits anxiolytic and anticonvulsant activities through potentiation of the GABA(A) receptor.
Positive_regulation (potentiation) of ) receptor associated with gaba, anxiety disorder and anticonvulsant
6) Confidence 0.09 Published 2002 Journal Biochemistry Section Abstract Doc Link 12416991 Disease Relevance 0.10 Pain Relevance 0.10
In vertebrate INSL3/relaxin binding GPCRs, a combination of a single cysteine-rich LDL-A domain and multiple LRRs at the ectodomain site is necessary for ligand binding, receptor activation and further downstream signalling from these receptors [45].
Positive_regulation (necessary) of receptor
7) Confidence 0.02 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0
A cannabinoid receptor homolog (ci0100149095) and a receptor (ci0100136887) that is most closely related to the lysophospholipid receptors were also identified.
Positive_regulation (related) of receptor associated with cannabinoid receptor
8) Confidence 0.02 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.05 Pain Relevance 0.15
Withdrawal symptoms result from a compensatory increase in the activity of excitatory mechanisms (upregulation) involving the neurotransmitters norepinephrine, dopamine, and the N-methyl-D-aspartate (NMDA) receptor, and diminished activity (downregulation) of the inhibitory receptors  ?
Positive_regulation (increase) of receptor associated with dopamine, neurotransmitter and withdrawal
9) Confidence 0.02 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 2.06 Pain Relevance 0.86
As a result of glutamate receptor activation, postsynaptic Ca2+ transients slow down receptor diffusion, according to the degree of synaptic usage (Borgdorff and Choquet, 2002).
Positive_regulation (activation) of receptor associated with glutamate receptor
10) Confidence 0.02 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0 Pain Relevance 0.34
As a result of glutamate receptor activation, postsynaptic Ca2+ transients slow down receptor diffusion, according to the degree of synaptic usage (Borgdorff and Choquet, 2002).
Positive_regulation (activation) of receptor associated with glutamate receptor
11) Confidence 0.02 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526001 Disease Relevance 0 Pain Relevance 0.34
The modification enhanced the mu receptor affinity 5-fold in the case of modified beta-CM-7 and 2-fold for modified beta-CM-5 when compared to the natural peptides.
Positive_regulation (enhanced) of receptor
12) Confidence 0.02 Published 2000 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 10866377 Disease Relevance 0 Pain Relevance 0.12
At the onset of labour both preterm and at term no marked increase in the OT receptor concentration was observed, but OT may still be involved in the initiation of labour, being produced locally in the uterus and not detectable in plasma.
Neg (no) Positive_regulation (increase) of receptor in uterus
13) Confidence 0.02 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8714023 Disease Relevance 0.15 Pain Relevance 0.23
The data indicate a similarity in the mode of TRH and MSH activation of the MCI receptor.
Positive_regulation (activation) of MCI receptor
14) Confidence 0.01 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.14 Pain Relevance 0.07
When coupled with an increase in IL-1 receptor and ICE with increasing degeneration, the net effect would be the initiation and perpetuation of an IL-1-mediated response.
Positive_regulation (increase) of receptor
15) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.23 Pain Relevance 0.08
The genetics aberrations of the Follicular Thyroid cancer includes the translocation (t[2,3][q13;p25]) [48] that results in fusion of part of the DNA-binding segment of the PAX8 gene and the peroxisome proliferator-activated receptor gamma 1 (PPAR-gamma-1) gene; PAX8 is a thyroid transcription factor and PPAR-gamma-1 is a transcription factor that stimulates cell differentiation and inhibits cell growth.
Positive_regulation (activated) of receptor in Thyroid associated with thyroid neoplasm
16) Confidence 0.01 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.47 Pain Relevance 0
Chronic opioid receptor (OR) activation by morphine causes distinct cellular adaptations responsible for the development of tolerance.
Positive_regulation (activation) of receptor associated with tolerance, opioid receptor and morphine
17) Confidence 0.01 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451120 Disease Relevance 0.13 Pain Relevance 0.82
Moreover, attenuation of beta-arrestin1 function appears to depend on persistent stimulation of MAP kinase activity during the course of chronic morphine treatment, because coincubation of the cells together with the MAP kinase blocker PD98059 fully restored beta-arrestin1 translocation and receptor internalization.
Positive_regulation (restored) of receptor associated with morphine
18) Confidence 0.01 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451120 Disease Relevance 0.11 Pain Relevance 1.05
Similarly, the c-Kit and platelet-derived growth factor receptor inhibitor, Imatinib, has shown remarkable success in chronic myeloid leukemia and GIST, cancers that are maintained by the activation of these receptor tyrosine kinases.
Positive_regulation (activation) of receptor in platelet associated with leukemia, cancer and gastrointestinal stromal tumor
19) Confidence 0.01 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.75 Pain Relevance 0
The conservation of the accessibility pattern on the cytoplasmic side of 6.54 suggests that this region may be important for receptor activation.
Positive_regulation (activation) of receptor
20) Confidence 0.01 Published 2001 Journal Biochemistry Section Abstract Doc Link 11434771 Disease Relevance 0.08 Pain Relevance 0.23

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