INT54662

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 19.33
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Chondrocytes 2
neurons 2
mononuclear cells 2
cerebellum 2
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 628 100.00 Very High Very High Very High
cytokine 445 100.00 Very High Very High Very High
Central nervous system 148 100.00 Very High Very High Very High
Enkephalin 9 99.80 Very High Very High Very High
Osteoarthritis 92 99.62 Very High Very High Very High
Neuropeptide 8 98.86 Very High Very High Very High
Arthritis 136 98.84 Very High Very High Very High
central sensitization 3 98.52 Very High Very High Very High
medulla 30 97.60 Very High Very High Very High
Multiple sclerosis 23 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 760 100.00 Very High Very High Very High
Ataxia 5 100.00 Very High Very High Very High
Alzheimer's Dementia 212 99.84 Very High Very High Very High
Death 94 99.72 Very High Very High Very High
Fever 48 99.64 Very High Very High Very High
Osteoarthritis 100 99.62 Very High Very High Very High
Multiple Sclerosis 18 99.60 Very High Very High Very High
Bacterial Respiratory Disease 2 99.04 Very High Very High Very High
Arthritis 153 98.84 Very High Very High Very High
Periodontitis 16 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date most studies have focused on the CNS actions of IL-1?
Positive_regulation (focused) of Positive_regulation (actions) of IL-1 associated with central nervous system
1) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.40 Pain Relevance 0.32
Experimentally induced elevations of IL-1?
Positive_regulation (induced) of Positive_regulation (elevations) of IL-1
2) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.20 Pain Relevance 0.20
The initial stimulus for elevation of IL-1 in AD is likely the result of exposure of microglia to injured neurons, ?
Positive_regulation (stimulus) of Positive_regulation (elevation) of IL-1 in neurons associated with alzheimer's dementia
3) Confidence 0.43 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.74 Pain Relevance 0.11
These results provide additional evidence for the immunoregulatory role of neuropeptides and suggest that the modulatory action of MENK could be mediated, at least in part, through the up-regulation of cytokines, most probably IL-1 and TNF.
Positive_regulation (mediated) of Positive_regulation (up-regulation) of IL-1 associated with neuropeptide, enkephalin and cytokine
4) Confidence 0.38 Published 1994 Journal Immunol. Lett. Section Abstract Doc Link 7927513 Disease Relevance 0.12 Pain Relevance 0.89
These studies suggest that increased levels of IL-1?
Positive_regulation (levels) of Positive_regulation (increased) of IL-1
5) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.97 Pain Relevance 0.55
-induced upregulation of IL-1?
Positive_regulation (induced) of Positive_regulation (upregulation) of IL-1
6) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.28 Pain Relevance 0.31
Upon stimulation with IL-1?
Positive_regulation (Upon) of Positive_regulation (stimulation) of IL-1
7) Confidence 0.13 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.18 Pain Relevance 0.17
, suggesting that alternative mechanisms might trigger the induction of mature IL-1?
Spec (might) Positive_regulation (trigger) of Positive_regulation (induction) of IL-1
8) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.46 Pain Relevance 0.23
We observed a significant up-regulation of IL-1?
Positive_regulation (up) of Positive_regulation (regulation) of IL-1
9) Confidence 0.10 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0 Pain Relevance 0.29
High glucose leads to an increase in IL-1?
Positive_regulation (leads) of Positive_regulation (increase) of IL-1
10) Confidence 0.07 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.35 Pain Relevance 0.23
There were non-significant trends towards an immediate increase of IL-1?
Positive_regulation (immediate) of Positive_regulation (increase) of IL-1
11) Confidence 0.07 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.24 Pain Relevance 0.09
Chondrocytes from OA cartilage display high levels of IL-1?
Positive_regulation (high) of Positive_regulation (levels) of IL-1 in Chondrocytes associated with osteoarthritis
12) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.96 Pain Relevance 0.69
In addition, mononuclear cells from FMF patients release higher levels of IL-1?
Positive_regulation (higher) of Positive_regulation (levels) of IL-1 in mononuclear cells associated with fever
13) Confidence 0.05 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.97 Pain Relevance 0.24
In the cerebellum, where KA was demonstrate to induce ataxia partially via elevation of IL-1?
Spec (partially) Positive_regulation (induce) of Positive_regulation (elevation) of IL-1 in cerebellum associated with ataxia
14) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.61 Pain Relevance 0.17
For example, patients with refractory periodontitis, a condition in which oral health does not improve despite treatment and proper hygiene, release higher levels of IL-1?
Positive_regulation (higher) of Positive_regulation (levels) of IL-1 associated with periodontitis
15) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.49 Pain Relevance 0.24
Elevated levels of interleukin 1 (IL-1) have been found in gingival crevicular fluid (GCF) of patients with experimentally induced gingivitis and active periodontal disease (Masada et al 1990; Kinane et al 1992).
Positive_regulation (Elevated) of Positive_regulation (levels) of IL-1 associated with mouth disease and periodontal disease
16) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.95 Pain Relevance 0.10
has been reported to induce COX-2 in various tissues including glia, it has been proposed that a vicious cycle occurs whereby ATP release (from cell death for example) leads to P2X7R activation, IL-1?
Positive_regulation (leads) of Positive_regulation (activation) of IL-1 associated with death
17) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 1.10 Pain Relevance 0.20
LL-37 has now been shown to induce caspase-1 activation and secretion of mature IL-1?
Positive_regulation (induce) of Positive_regulation (activation) of IL-1
18) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.32 Pain Relevance 0.14
Activation of the CpG ODN/TLR9 signalling pathway culminates in the activation of several transcription factors [10, 88, 89] which directly up-regulate production of pro-inflammatory cytokines (IL-1, -6, -10, -12 -18, GM-CSF, TNF-?
Positive_regulation (Activation) of Positive_regulation (activation) of IL-1 associated with inflammation and cytokine
19) Confidence 0.03 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.38 Pain Relevance 0.22
Relevant to our model, Substance-P has been shown to participate in upregulation of inflammatory cytokines in fibroblastic cells[63], [64] and more recently in a model of increased IL-6, IL-1?
Positive_regulation (upregulation) of Positive_regulation (increased) of IL-1 associated with inflammation and cytokine
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.92 Pain Relevance 0.26

General Comments

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