INT54681

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Context Info
Confidence 0.38
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.70
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
SK-N-MC 2
lutein cells 2
platelet 2
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 15 100.00 Very High Very High Very High
Morphine 14 99.92 Very High Very High Very High
agonist 55 99.90 Very High Very High Very High
Opioid 13 99.82 Very High Very High Very High
headache 2 99.48 Very High Very High Very High
Dynorphin 6 99.04 Very High Very High Very High
Cluster headache 3 98.56 Very High Very High Very High
mu opioid receptor 12 97.48 Very High Very High Very High
opiate 5 97.48 Very High Very High Very High
Migraine 8 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 8 99.48 Very High Very High Very High
Cluster Headache 4 98.56 Very High Very High Very High
Migraine With Aura 1 97.72 Very High Very High Very High
Migraine Without Aura 1 96.92 Very High Very High Very High
Neuroblastoma 3 95.04 Very High Very High Very High
Disease 1 86.48 High High
Inflammatory Pain 1 84.36 Quite High
Pain 3 80.64 Quite High
Neurogenic Inflammation 1 78.72 Quite High
Diabetes Mellitus 1 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduced capability to inhibit forskolin-stimulated adenylyl cyclase activity in headache patients was observed.
Negative_regulation (inhibit) of Positive_regulation (forskolin-stimulated) of adenylyl cyclase associated with headache
1) Confidence 0.38 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.90 Pain Relevance 0.99
The overall pharmacological profile for the human 5-HT1Dbeta receptor, defined using [35S]-GTPgammaS binding, agreed well with that reported for inhibition of forskolin-stimulated adenylyl cyclase.
Negative_regulation (inhibition) of Positive_regulation (forskolin-stimulated) of adenylyl cyclase
2) Confidence 0.37 Published 1995 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 8903941 Disease Relevance 0 Pain Relevance 0.30
Collectively, our results show that although Gz mediated opioid-induced inhibition of adenylyl cyclase and activation of ERK1/2, Gz alone was insufficient to mediate opioid-induced adenylyl cyclase supersensitization.
Negative_regulation (inhibition) of Positive_regulation (activation) of adenylyl cyclase associated with opioid
3) Confidence 0.37 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0 Pain Relevance 0.58
These results indicate that subtypes adenylyl cyclase I, III and VIII, which are activated by calcium, and adenylyl cyclase V and VI, which are inhibited by calcium, are not dominant isoforms in granulosa-lutein cells.
Negative_regulation (inhibited) of Positive_regulation (activated) of cyclase in lutein cells
4) Confidence 0.34 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.24
In signal transduction assays using cells expressing recombinant h5-HT1D alpha, h5-HT1D beta, or h5-HT1A receptors, alniditan (like 5-HT) was a full agonist for inhibition of stimulated adenylyl cyclase (IC50 = 1.1, 1.3, and 74 nM, respectively, for alniditan).
Negative_regulation (inhibition) of Positive_regulation (stimulated) of cyclase associated with agonist
5) Confidence 0.28 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967979 Disease Relevance 0.20 Pain Relevance 0.75
The chimeric opiate receptor displays evidence for effective G-protein coupling; 100 nM dynorphin A-(1-17) is as effective as 100 nM morphine at inhibiting forskolin-stimulated adenyl cyclase activity through actions at the chimeric receptor.
Negative_regulation (inhibiting) of Positive_regulation (stimulated) of adenyl cyclase associated with dynorphin, opiate and morphine
6) Confidence 0.26 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7929306 Disease Relevance 0 Pain Relevance 1.08
Inhibition of forskolin-stimulated adenylyl cyclase and phospholipase C beta (PLC beta) activation was measured in each of these cell lines.
Negative_regulation (Inhibition) of Positive_regulation (stimulated) of adenylyl cyclase
7) Confidence 0.16 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.25
Hsp90AB1 transcript and protein levels increased significantly during morphine treatment, and co-application of geldanamycin (0.1-10 nM) effectively suppressed the increase in forskolin-activated adenylate cyclase activation by 56%.
Negative_regulation (suppressed) of Positive_regulation (activation) of cyclase associated with morphine
8) Confidence 0.14 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100459 Disease Relevance 0.29 Pain Relevance 0.58
These results indicate that Hsp90 is a new pharmacological target for the suppression of adenylate cyclase sensitization induced by chronic morphine treatment.
Negative_regulation (suppression) of Positive_regulation (induced) of cyclase associated with morphine
9) Confidence 0.14 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100459 Disease Relevance 0.26 Pain Relevance 0.50
During these studies, we observed that forskolin activation of adenylyl cyclase was greatly reduced in filamin-lacking cells.
Negative_regulation (reduced) of Positive_regulation (activation) of adenylyl cyclase
10) Confidence 0.14 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.13 Pain Relevance 0.71
The ADP receptor responsible for the ADP-induced platelet aggregation and inhibition of stimulated adenylyl cyclase activity has not been cloned due to difficulties in screening responsive clones generated from a cDNA library.
Negative_regulation (inhibition) of Positive_regulation (stimulated) of adenylyl cyclase in platelet
11) Confidence 0.12 Published 1998 Journal J. Protein Chem. Section Abstract Doc Link 9717739 Disease Relevance 0.30 Pain Relevance 0.12
Inhibition of forskolin-stimulated adenylyl cyclase and phospholipase C beta (PLC beta) activation was measured in each of these cell lines.
Negative_regulation (Inhibition) of Positive_regulation (stimulated) of adenylyl cyclase
12) Confidence 0.12 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0 Pain Relevance 0.25
SB-(+)-273779 also inhibited CGRP (3 nM)-activated adenylyl cyclase in these systems with IC(50) values of 390 +/-10 nM (in SK-N-MC) and 210 +/-16 nM (recombinant human CGRP receptors).
Negative_regulation (inhibited) of Positive_regulation (-activated) of adenylyl cyclase in SK-N-MC associated with calcitonin gene-related peptide
13) Confidence 0.08 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181905 Disease Relevance 0.46 Pain Relevance 0.81
Individual activation of either deltaOR or SNSR-4 in cells coexpressing the two receptors led to the modulation of their respective signaling pathways; inhibition of adenylyl cyclase and activation of phospholipase C, respectively.
Negative_regulation (inhibition) of Positive_regulation (activation) of adenylyl cyclase
14) Confidence 0.05 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682504 Disease Relevance 0.08 Pain Relevance 0.40
Activation of A1 and A3 receptors induces the inhibition of the enzyme adenylate cyclase mediated by an inhibitory G protein (Gi).
Negative_regulation (inhibition) of Positive_regulation (mediated) of cyclase
15) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.21
We found that forskolin, a stimulator of adenylate cyclase, decreased desensitization of TRPV1.
Negative_regulation (decreased) of Positive_regulation (stimulator) of cyclase
16) Confidence 0.00 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14506258 Disease Relevance 0.08 Pain Relevance 0.38

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