INT54701

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 18.68
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 9
macrophages 3
microglia 2
eosinophils 1
leukocytes 1
Ptafr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 161 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
alcohol 2 100.00 Very High Very High Very High
Bile 1 100.00 Very High Very High Very High
cytokine 56 98.86 Very High Very High Very High
chemokine 103 98.16 Very High Very High Very High
tolerance 2 96.40 Very High Very High Very High
Neurotransmitter 13 95.92 Very High Very High Very High
Inflammatory response 32 94.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 211 100.00 Very High Very High Very High
Stress 68 100.00 Very High Very High Very High
Anaphylaxis 10 100.00 Very High Very High Very High
Cancer 9 99.76 Very High Very High Very High
Pulmonary Edema 7 99.76 Very High Very High Very High
Shock 6 99.64 Very High Very High Very High
Necrosis 8 99.52 Very High Very High Very High
Rhinitis 3 99.52 Very High Very High Very High
Inflammatory Bowel Disease 25 99.30 Very High Very High Very High
Infection 141 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet-activating factor: diminished acetylcholine release from rat brain slices is mediated by a Gi protein.
Localization (release) of Platelet-activating factor in Platelet
1) Confidence 0.49 Published 1994 Journal J. Neurochem. Section Title Doc Link 7931326 Disease Relevance 0.07 Pain Relevance 0.24
Blockade of cyclo-oxygenase with indomethacin or of lipoxygenase with ICI 207968 or of phospholipase A2 with mepacrine inhibited release of prostaglandin E2 or leukotriene C4 or both of these plus platelet-activating factor, respectively. 4.
Localization (release) of platelet-activating factor in platelet
2) Confidence 0.32 Published 1994 Journal Clin. Sci. Section Abstract Doc Link 8033515 Disease Relevance 0.33 Pain Relevance 0.23
Regarding the pathogenesis of these mucosal rings our hypothesis is that mast cells in the esophageal wall in response to allergens release histamine, eosinophilic chemotactic factor and platelet activating factor, etc. which activate eosinophils to release toxic cationic proteins.
Localization (release) of platelet activating factor in eosinophils associated with rhinitis
3) Confidence 0.25 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15617859 Disease Relevance 1.46 Pain Relevance 0.25
It is well known that the gastric mucosa can resist autodigestion although it is exposed to numerous noxious stimuli like aggressive secretions of hydrochloric acid, pepsin, reflex of bile, spicy food, microorganisms, formation of free radicals, stress, alcohol, 5-hydroxy tryptamine, substance P (SP), slow releasing substance, irritant receptors and platelet activating factor.
Spec (like) Localization (secretions) of platelet activating factor in platelet associated with stress, bile, substance p and alcohol
4) Confidence 0.24 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2937322 Disease Relevance 0.78 Pain Relevance 0.20
Studies on isolated organs, tissues, cells and enzymes have revealed that Schizandra preparations exhibit strong antioxidant activities and affect smooth muscles, arachidonic acid release, biosynthesis of leukotriene B(4) in leukocytes, platelet activating factor activity, carbohydrate-phosphorus metabolism, the formation of heat shock protein and polyamines, tissue respiration and oxygen consumption, and the tolerance of an organism to oxygen intoxication.
Localization (formation) of platelet activating factor in leukocytes associated with shock, tolerance and poisoning
5) Confidence 0.23 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18515024 Disease Relevance 1.06 Pain Relevance 0.12
Cytokines and other mediators such as histamine, leukotrienes and platelet-activating factor are released from these inflammatory cells, and complex interactions between cells and mediators lead to structural and physiological changes and exposed parasympatic nerve endings [9,10,16,17].
Localization (released) of platelet-activating factor in nerve associated with inflammation and cytokine
6) Confidence 0.15 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2749010 Disease Relevance 1.23 Pain Relevance 0.14
Studies on isolated organs, tissues, cells and enzymes have revealed that Schizandra preparations exhibit strong antioxidant activities and affect smooth muscles, arachidonic acid release, biosynthesis of leukotriene B(4) in leukocytes, platelet activating factor activity, carbohydrate-phosphorus metabolism, the formation of heat shock protein and polyamines, tissue respiration and oxygen consumption, and the tolerance of an organism to oxygen intoxication.
Localization (formation) of platelet activating factor in platelet associated with shock, tolerance and poisoning
7) Confidence 0.08 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18515024 Disease Relevance 1.06 Pain Relevance 0.12
These mononuclear phagocytes, as well as hepatic endothelial cells and stellate cells, are activated to release increased amounts of proinflammatory and cytotoxic mediators including hydrogen peroxide, superoxide anion, nitric oxide, bioactive lipids, interleukin 1, platelet activating factor, and tumor necrosis factor alpha.
Localization (release) of platelet activating factor in platelet associated with necrosis and cancer
8) Confidence 0.08 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8839288 Disease Relevance 0.60 Pain Relevance 0.17
These include; stimulation of the platelet activating factor, release of lysophosphatides, and disturbances of potassium, sodium, and calcium conductance.10
Localization (release) of platelet activating factor in platelet
9) Confidence 0.07 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 1.38 Pain Relevance 0.19
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (release) of platelet activating factor in microglia associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
10) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.23 Pain Relevance 0.22
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (released) of platelet activating factor in microglia associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
11) Confidence 0.04 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.09 Pain Relevance 0.22
In IBD, there is increased synthesis and release of pro-inflammatory mediators, such as eicosanoids, platelet activating factor, reactive oxygen species (ROS), nitrogen metabolites, chemokines and mainly cytokines [5] that have been associated with disease severity, activity and remission [2].
Localization (release) of platelet activating factor in platelet associated with chemokine, inflammatory bowel disease, inflammatory mediators, disease and cytokine
12) Confidence 0.03 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2909993 Disease Relevance 1.75 Pain Relevance 0.37
The in vitro diagnosis of anaphylaxis includes, among other aspects, the serial measurement of mediators which are released in the course of an anaphylactic reaction such as tryptase, histamine, chymase, carboxypeptidase A3, platelet-activating factor and other products from mastocytes.
Localization (released) of platelet-activating factor in mastocytes associated with anaphylaxis
13) Confidence 0.03 Published 2010 Journal Chem Immunol Allergy Section Abstract Doc Link 20519886 Disease Relevance 0.64 Pain Relevance 0.05
And platelet-activating factor is released from neutrophil and causes platelet-mediated lung edema in isolated rabbit lung (27-29).
Localization (released) of platelet-activating factor in platelet associated with pressure and volume under development
14) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822264 Disease Relevance 0.82 Pain Relevance 0.23
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (release) of platelet activating factor in macrophages associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
15) Confidence 0.01 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.23 Pain Relevance 0.22
When activated through direct HIV infection or through exposure to viral particles, macrophages and microglia release numerous soluble molecules, including the viral proteins, gp120, Tat, and Vpr (only released from infected cells), quinolinic and arachidonic acids, nitric oxide (NO), platelet activating factor, superoxide anions, matrix metalloproteases, chemokines, growth factors, and proinflammatory cytokines, including tumor-necrosis factor (TNF; Albright et al. 2003; Gonzalez-Scarano and Martin-Garcia 2005).
Localization (released) of platelet activating factor in macrophages associated with chemokine, necrosis, cancer, acquired immune deficiency syndrome or hiv infection, infection and cytokine
16) Confidence 0.01 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.09 Pain Relevance 0.22
The important mediators released by platelets are P-selectin (CD62p), CD40p, platelet activating factor, macrophage chemotactic factor-1, interleukin-1, thrombospondin and fibronectin.
Localization (released) of platelet activating factor in macrophage
17) Confidence 0.01 Published 2004 Journal Thromb J Section Body Doc Link PMC406420 Disease Relevance 0.90 Pain Relevance 0.40
It is due to release of histamine, PGD2,[19] leukotrienes, platelet activating factor,[20] TNF?
Localization (release) of platelet activating factor in platelet
18) Confidence 0.01 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856370 Disease Relevance 1.04 Pain Relevance 0.06
Imai et al demonstrated that HFO could reduce the release of inflammatory chemical mediators, platelet-activating factor and thromboxane B2 in the surfactant-depleted rabbit lung [13].
Localization (release) of platelet-activating factor in lung associated with inflammation
19) Confidence 0.01 Published 1998 Journal Crit Care Section Body Doc Link PMC29000 Disease Relevance 0.92 Pain Relevance 0.17

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