INT54706

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.89
Pain Relevance 10.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
brain 4
spinal cord 1
frontal cortex 1
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 32 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
methadone 20 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
Kinase C 79 99.80 Very High Very High Very High
Spinal cord 9 99.68 Very High Very High Very High
fluoxetine 4 99.60 Very High Very High Very High
tolerance 22 99.58 Very High Very High Very High
agonist 132 99.42 Very High Very High Very High
Analgesic 4 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.52 Very High Very High Very High
Leukemia 1 92.88 High High
Neuropathic Pain 5 85.04 High High
Overdose 4 80.76 Quite High
Hyperalgesia 2 54.16 Quite High
Peripheral Neuropathy 1 47.20 Quite Low
Nash(non-alcoholic Steatohepatitis) 12 19.52 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of opiate drugs (heroin, morphine, and methadone) on the levels of G protein-coupled receptor kinase 2 (GRK2) were studied in rat and human brain frontal cortices.
Regulation (effects) of GRK2 in brain associated with methadone, opiate and morphine
1) Confidence 0.62 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.08 Pain Relevance 0.97
The effects of opiate drugs (heroin, morphine, and methadone) on the levels of G protein-coupled receptor kinase 2 (GRK2) were studied in rat and human brain frontal cortices.
Regulation (effects) of protein-coupled receptor kinase 2 in brain associated with methadone, opiate and morphine
2) Confidence 0.54 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.08 Pain Relevance 0.97
Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.
Regulation (Regulation) of protein-coupled receptor kinase 2 in brains associated with narcan and opiate
3) Confidence 0.54 Published 1998 Journal J. Neurochem. Section Title Doc Link 9489748 Disease Relevance 0.13 Pain Relevance 1.46
It is proposed that chronic morphine regulation of beta ARK1 and beta-arrestin levels may contribute to opioid-receptor tolerance that is known to occur in this brain region.
Regulation (regulation) of beta ARK1 in brain associated with tolerance, opioid and morphine
4) Confidence 0.50 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7931357 Disease Relevance 0 Pain Relevance 0.68
These data indicate that GRK2, GRK3, GRK6 and beta-arrestin 2 are involved in the short- and long-term adaptive changes in mu-opioid receptor activity, contributing to tolerance development in living animals.
Regulation (involved) of GRK2 associated with tolerance and opioid receptor
5) Confidence 0.40 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.18
Under these conditions, immunoblotting showed a robust increase in phosphorylated-cPKC immunoreactivity (p-cPKC-IR) in the spinal cord from chronic ethanol fed-rats, whereas phosphorylated-protein kinase A (PKA), dynamin II and G protein-coupled receptor kinase 2 (GRK2) were not affected in the spinal cord of ethanol-fed rats.
Neg (not) Regulation (affected) of GRK2 in spinal cord associated with spinal cord
6) Confidence 0.36 Published 2007 Journal Neuroscience Section Abstract Doc Link 17156932 Disease Relevance 0.34 Pain Relevance 1.66
Spontaneous and naloxone-precipitated withdrawal after chronic morphine or methadone induced a marked up-regulation in the levels of total GRK2 in the rat frontal cortex (18-25%).
Regulation (regulation) of GRK2 in frontal cortex associated with narcan, urological neuroanatomy, methadone, withdrawal and morphine
7) Confidence 0.27 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.17 Pain Relevance 1.65
In contrast, the acute in vivo activation of 5-HT receptors induced by fluoxetine does not result in modulation of GRK 2/3.
Regulation (modulation) of GRK 2 associated with fluoxetine
8) Confidence 0.26 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527474 Disease Relevance 0 Pain Relevance 0.53
The enhanced and prolonged desensitization of M1 mACh receptor signalling observed in picrotoxin- and agonist-treated cultures appears to depend on both GRK2 and PKC activities, as expression of the dominant-negative D110A,K220RGRK2 construct only partially ameliorated agonist-induced receptor desensitization and further amelioration was observed in the presence of either a PKC inhibitor, or following phorbol ester-induced down-regulation of PKC activities.
Spec (appears) Regulation (depend) of GRK2 associated with kinase c and agonist
9) Confidence 0.26 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.30
Acute and chronic treatment with sufentanil induced analgesic tolerance, associated with up-regulation of GRK2, GRK6, and beta-arrestin 2.
Regulation (regulation) of GRK2 associated with analgesic and tolerance
10) Confidence 0.24 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.17
These results indicate that the MAPK cascade is involved in A3R regulation by a feedback mechanism which controls GRK2 activity and probably involves direct receptor phosphorylation [97].
Regulation (controls) of GRK2
11) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.09 Pain Relevance 0.13

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