INT54707

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.51
Pain Relevance 9.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
neurons 2
tail 2
brain 2
NG108-15 1
locus coeruleus 1
Adrbk1 (Rattus norvegicus)
Adrbk1 - K220R (1)
Pain Link Frequency Relevance Heat
methadone 5 99.98 Very High Very High Very High
Morphine 23 99.72 Very High Very High Very High
tolerance 13 99.64 Very High Very High Very High
mu opioid receptor 7 99.64 Very High Very High Very High
noradrenaline 3 99.62 Very High Very High Very High
fluoxetine 12 99.60 Very High Very High Very High
withdrawal 6 99.56 Very High Very High Very High
Analgesic 2 99.44 Very High Very High Very High
Desipramine 21 99.32 Very High Very High Very High
Locus ceruleus 7 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.52 Very High Very High Very High
Overdose 1 73.72 Quite High
Anaplastic Astrocytoma 3 55.92 Quite High
Bordatella Infection 3 54.04 Quite High
Nash(non-alcoholic Steatohepatitis) 12 29.84 Quite Low
Convulsion 1 28.64 Quite Low
Increased Venous Pressure Under Development 3 5.92 Low Low
Cancer 11 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, spontaneous and naloxone-precipitated morphine withdrawal resulted in aberrant increases in GRK2 and GRK5 mRNA levels in these brain regions.
Positive_regulation (increases) of GRK2 in brain associated with narcan, withdrawal and morphine
1) Confidence 0.67 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12384166 Disease Relevance 0.08 Pain Relevance 1.54
These results suggest that homologous desensitization of rat mu-opioid receptors results from the activation of GRK2 and that a cluster of Ser/Thr residues (Thr354Ser355Ser356Thr357) at the intracellular carboxyl tail plays an important role in GRK2-mediated mu-opioid receptor desensitization.
Positive_regulation (activation) of GRK2 in tail associated with mu opioid receptor and opioid receptor
2) Confidence 0.62 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698001 Disease Relevance 0 Pain Relevance 0.40
The ability of mu-opioid receptors to develop homologous desensitization was greatly impaired following the transfection of a cDNA fragment encoding the GRK2(495-689) polypeptide, which is believed to block Gbetagamma-mediated transduction events including the membrane translocation and activation of GRK2.
Positive_regulation (activation) of GRK2 associated with mu opioid receptor
3) Confidence 0.62 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10698001 Disease Relevance 0 Pain Relevance 0.44
These results indicate that the prolonged activation of somatostatin receptors induces the desensitization of somatostatin-induced inhibition on low [Mg(2+)](o)-induced [Ca(2+)](i) spikes through the activation of GRK2 and partly a novel PKCepsilon in cultured rat hippocampal neurons.
Positive_regulation (activation) of GRK2 in neurons associated with somatostatin
4) Confidence 0.62 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.05 Pain Relevance 0.52
Chronic morphine administration increases beta-adrenergic receptor kinase (beta ARK) levels in the rat locus coeruleus.
Positive_regulation (increases) of beta-adrenergic receptor kinase in locus coeruleus associated with locus ceruleus and morphine
5) Confidence 0.57 Published 1994 Journal J. Neurochem. Section Title Doc Link 7931357 Disease Relevance 0 Pain Relevance 0.60
Spontaneous and naloxone-precipitated withdrawal after chronic morphine or methadone induced a marked up-regulation in the levels of total GRK2 in the rat frontal cortex (18-25%).
Positive_regulation (induced) of GRK2 in frontal cortex associated with narcan, urological neuroanatomy, methadone, withdrawal and morphine
6) Confidence 0.50 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.17 Pain Relevance 1.66
Acute desipramine (noradrenaline reuptake blocker) increased in a dose- (1-30 mg/kg, i.p.) and time- (1-6 h) dependent manner the content of GRK 2/3 in the membrane (P2/H ratios increased by 37-164%).
Positive_regulation (increased) of GRK 2 associated with desipramine and noradrenaline
7) Confidence 0.49 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527474 Disease Relevance 0.09 Pain Relevance 0.64
In contrast, the acute in vivo activation of 5-HT receptors induced by fluoxetine does not result in modulation of GRK 2/3.
Positive_regulation (modulation) of GRK 2 associated with fluoxetine
8) Confidence 0.49 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527474 Disease Relevance 0 Pain Relevance 0.53
The results indicate that the in vivo activation of adrenoceptors by desipramine is associated with a time-dependent modulation of membrane-associated GRK 2/3 (i.e. an acute increase in the kinase content which is followed by a return to the basal expression upon repeated treatment).
Positive_regulation (increase) of GRK 2 associated with desipramine
9) Confidence 0.45 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527474 Disease Relevance 0.06 Pain Relevance 0.64
Acute and chronic treatment with sufentanil induced analgesic tolerance, associated with up-regulation of GRK2, GRK6, and beta-arrestin 2.
Positive_regulation (up-regulation) of GRK2 associated with analgesic and tolerance
10) Confidence 0.45 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11299311 Disease Relevance 0 Pain Relevance 1.17
It was found that chronic morphine treatment produced an approximately 35% increase in levels of beta ARK1 immunoreactivity in the locus coeruleus, but not in several other brain regions studied.
Positive_regulation (increase) of beta ARK1 in brain associated with locus ceruleus and morphine
11) Confidence 0.41 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 7931357 Disease Relevance 0 Pain Relevance 0.62
q/11), suggest that the phosphorylation-dependent activity of endogenous GRK2 is required for M1 mACh receptor desensitization in synaptically-active hippocampal neurons (Willets et al. 2005).
Positive_regulation (required) of GRK2 in neurons
12) Confidence 0.28 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.23
In addition, stable transfection of a dominant negative GRK2(Lys220Arg) mutant in the NG108-15 cells reduced the NECA-induced (30 min, 100 ?
Positive_regulation (negative) of GRK2 (K220R) in NG108-15
13) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.06 Pain Relevance 0.16
Activation of GRK2 led to the phosphorylation of serine residues in the C-terminal tail, which facilitates beta-arrestin1/2 membrane translocation.
Positive_regulation (Activation) of GRK2 in tail
14) Confidence 0.06 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19014372 Disease Relevance 0 Pain Relevance 0.36

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