INT54709

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.18
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
NG108-15 4
neurons 2
locus coeruleus 2
Adrbk1 (Rattus norvegicus)
Adrbk1 - K220R (1)
Pain Link Frequency Relevance Heat
agonist 239 99.96 Very High Very High Very High
Morphine 8 99.68 Very High Very High Very High
Locus ceruleus 3 99.52 Very High Very High Very High
opioid receptor 19 99.28 Very High Very High Very High
Opioid 6 93.44 High High
adenocard 120 92.48 High High
Immobilon 3 86.60 High High
MU agonist 2 81.36 Quite High
addiction 2 75.68 Quite High
tolerance 5 75.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 22 61.20 Quite High
Necrosis 2 60.64 Quite High
Anaplastic Astrocytoma 6 55.92 Quite High
Increased Venous Pressure Under Development 6 7.00 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Nash(non-alcoholic Steatohepatitis) 12 5.00 Very Low Very Low Very Low
Hypoxia 10 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In D110A,K220RGRK2-transfected neurons the R2/R1 ratio difference was dramatically reduced indicating that inhibition of endogenous GRK2 attenuates M1 mACh receptor desensitization under all conditions, including those where the extent of receptor desensitization was increased by picrotoxin treatment (see Fig. 3e).
Positive_regulation (transfected) of Gene_expression (transfected) of GRK2 in neurons
1) Confidence 0.49 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.10
Chronic morphine administration increases beta-adrenergic receptor kinase (beta ARK) levels in the rat locus coeruleus.
Positive_regulation (increases) of Gene_expression (levels) of beta-adrenergic receptor kinase in locus coeruleus associated with locus ceruleus and morphine
2) Confidence 0.38 Published 1994 Journal J. Neurochem. Section Title Doc Link 7931357 Disease Relevance 0 Pain Relevance 0.61
The acute stimulation of adenylyl cyclase by activation of A2AR was markedly reduced in NG108-15 cells overexpressing wild-type GRK2.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GRK2 in NG108-15
3) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.12 Pain Relevance 0.22
In addition, stable transfection of a dominant negative GRK2(Lys220Arg) mutant in the NG108-15 cells reduced the NECA-induced (30 min, 100 ?
Positive_regulation (negative) of Gene_expression (transfection) of GRK2 (K220R) in NG108-15
4) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.06 Pain Relevance 0.17
Coexpression of GRK2 strongly enhanced agonist-stimulated phosphorylation of the wild-type DOR (WT), but Delta15 or mutant DOR (T358A/T361A/S363G) failed to show any detectable phosphorylation under these conditions.
Positive_regulation (enhanced) of Gene_expression (Coexpression) of GRK2 associated with agonist and opioid receptor
5) Confidence 0.10 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 11040053 Disease Relevance 0 Pain Relevance 0.96
Unlike for the mu OR, overexpression of GRK2 results in neither the enhancement of delta OR sequestration nor the rescue of delta OR-mediated beta-arrestin translocation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GRK2
6) Confidence 0.07 Published 1999 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 10071766 Disease Relevance 0 Pain Relevance 1.07

General Comments

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