INT54720

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Context Info
Confidence 0.34
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.70
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB5) Golgi apparatus (HLA-DRB5) endoplasmic reticulum (HLA-DRB5)
plasma membrane (HLA-DRB5)
Anatomy Link Frequency
leukocyte 1
HLA-DRB5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 11 100.00 Very High Very High Very High
Neuritis 17 99.84 Very High Very High Very High
imagery 9 98.00 Very High Very High Very High
Inflammation 51 84.96 Quite High
cINOD 14 81.48 Quite High
cytokine 26 25.00 Low Low
COX2 3 25.00 Low Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 76 100.00 Very High Very High Very High
Death 65 100.00 Very High Very High Very High
Demyelinating Disease 11 100.00 Very High Very High Very High
Optic Neuritis 17 99.84 Very High Very High Very High
Congenital Anomalies 2 98.56 Very High Very High Very High
Stomach Cancer 10 96.48 Very High Very High Very High
Hepatocellular Cancer 2 96.12 Very High Very High Very High
Liver Disease 43 88.40 High High
INFLAMMATION 64 84.96 Quite High
Cancer 6 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A compilation of published data on the frequency of the HLA-DR17(3), DQ2 haplotype, prompted by a slight increase in this material, revealed a significant association with this haplotype in ON, after compensation for the increase of Dw2.
Positive_regulation (increase) of Dw2
1) Confidence 0.34 Published 1996 Journal Acta Neurol. Scand. Section Body Doc Link 8899048 Disease Relevance 0.14 Pain Relevance 0
UNLABELLED: The human leukocyte antigen (HLA) phenotype Dw2 is known to be increased in multiple sclerosis (MS), but only slightly in optic neuritis (ON).
Positive_regulation (increased) of Dw2 in leukocyte associated with multiple sclerosis, optic neuritis and neuritis
2) Confidence 0.30 Published 1996 Journal Acta Neurol. Scand. Section Abstract Doc Link 8899048 Disease Relevance 0.35 Pain Relevance 0.26
The HLA-Dw2 phenotype was significantly increased in ON patients compared with controls, but also significantly different from a group of MS patients from the same geographical area.
Positive_regulation (increased) of Dw2 associated with multiple sclerosis and neuritis
3) Confidence 0.04 Published 1994 Journal J. Neurol. Section Abstract Doc Link 7931435 Disease Relevance 1.22 Pain Relevance 1.19
We conclude that NAG-1 expression is closely related to DR-4 and DR-5 induction, which could provide a mechanistic basis for the apoptotic effect of COX inhibitors in gastric cancer cells.
Positive_regulation (induction) of DR-5 associated with apoptosis and stomach cancer
4) Confidence 0.01 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.13 Pain Relevance 0.28
RESULTS: The frequency of HLA-DR15 was significantly increased in patients with ON + CDMS (52%) and ON (47%) compared with control subjects (31%).
Positive_regulation (increased) of HLA-DR15
5) Confidence 0.01 Published 1997 Journal Arch. Neurol. Section Body Doc Link 9006417 Disease Relevance 0.28 Pain Relevance 0
Moreover, temporal expressions of DR-4 and DR-5 induced by sulindac sulfide were similar to that of NAG-1.
Positive_regulation (induced) of DR-5
6) Confidence 0.01 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.02 Pain Relevance 0.32
Activation of pathways leading to increased mitochondrial ROS generation and related to cell death (apoptotic or not) may be elicited by TNF, mainly by acting on the TNF receptor TNFRI, but a significant role for ROS has also been described in the activation of Fas as well as other death receptors, such as DR-4 and DR-5 [107].
Positive_regulation (activation) of DR-5 associated with apoptosis and death
7) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.99 Pain Relevance 0.04
SNU668 cells with ectopic expression of NAG-1 showed markedly elevated subG1 population, induced death receptor-4 (DR-4) and DR-5, and revealed smaller active fragments of caspase-3.
Positive_regulation (induced) of DR-5 associated with death
8) Confidence 0.01 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699947 Disease Relevance 0.59 Pain Relevance 0.13
Forced NAG-1 expression significantly induced apoptosis and DR-4 and DR-5 expression.
Positive_regulation (induced) of DR-5 associated with apoptosis
9) Confidence 0.00 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 0.98 Pain Relevance 0.29

General Comments

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