INT54738

Context Info Confidence 0.37 First Reported 1994 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.01 Pain Relevance 1.70

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2) nucleus (NCOR2) DNA binding (NCOR2)

NCOR2 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 3 100.00 Enkephalin 3 99.70 Pain 4 98.86 antagonist 8 98.56 diffuse noxious inhibitory control 4 90.76 agonist 6 81.24 opiate 4 80.88 narcan 1 49.28 headache 1 49.28 nociceptor 1 25.00

Disease Link Frequency Relevance Heat Pain 4 98.86 Nociception 7 84.28 Neuroblastoma 2 83.44 Primary Headache Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Compared to single pulses, double and triple pulses increased the sensation of pain, reduced the tactile and pain thresholds, and facilitated the blink reflex responses (reduced onset latency, increased magnitude and persistence of nR2).

Negative_regulation (reduced) of Negative_regulation (persistence) of nR2 associated with pain

1) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15109515 Disease Relevance 0.85 Pain Relevance 0.69

Conversely, the delta antagonist (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH([N,N-diallyl-Tyr1, Aib2,3]Leu- enkephalin)] ICI 174,864 blocked morphine-induced down-regulation of delta but not mu receptors.

Negative_regulation (blocked) of Negative_regulation (down-regulation) of receptors associated with antagonist, enkephalin and morphine

2) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.16 Pain Relevance 1.00

General Comments

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