INT54738

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Context Info
Confidence 0.37
First Reported 1994
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 3 100.00 Very High Very High Very High
Enkephalin 3 99.70 Very High Very High Very High
Pain 4 98.86 Very High Very High Very High
antagonist 8 98.56 Very High Very High Very High
diffuse noxious inhibitory control 4 90.76 High High
agonist 6 81.24 Quite High
opiate 4 80.88 Quite High
narcan 1 49.28 Quite Low
headache 1 49.28 Quite Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 4 98.86 Very High Very High Very High
Nociception 7 84.28 Quite High
Neuroblastoma 2 83.44 Quite High
Primary Headache Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to single pulses, double and triple pulses increased the sensation of pain, reduced the tactile and pain thresholds, and facilitated the blink reflex responses (reduced onset latency, increased magnitude and persistence of nR2).
Negative_regulation (reduced) of Negative_regulation (persistence) of nR2 associated with pain
1) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15109515 Disease Relevance 0.85 Pain Relevance 0.69
Conversely, the delta antagonist (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH([N,N-diallyl-Tyr1, Aib2,3]Leu- enkephalin)] ICI 174,864 blocked morphine-induced down-regulation of delta but not mu receptors.
Negative_regulation (blocked) of Negative_regulation (down-regulation) of receptors associated with antagonist, enkephalin and morphine
2) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932156 Disease Relevance 0.16 Pain Relevance 1.00

General Comments

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