INT54739

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
brain 2
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 55 100.00 Very High Very High Very High
fortral 9 100.00 Very High Very High Very High
antagonist 9 99.58 Very High Very High Very High
narcan 9 99.46 Very High Very High Very High
Parenteral administration 1 99.24 Very High Very High Very High
opiate 10 99.16 Very High Very High Very High
Nucleus accumbens 1 97.80 Very High Very High Very High
Dopamine 1 96.28 Very High Very High Very High
Opioid 32 87.60 High High
Catecholamine 2 85.32 High High
Disease Link Frequency Relevance Heat
Pseudomonas Infection 1 87.52 High High
Stress 1 81.52 Quite High
Cv Unclassified Under Development 1 60.00 Quite High
Reperfusion Injury 1 59.28 Quite High
Apoptosis 5 54.64 Quite High
Infection 78 50.00 Quite Low
Opiate Addiction 7 41.80 Quite Low
Pneumococcal Infection 1 41.28 Quite Low
Sleep Disorders 75 24.32 Low Low
Immunodeficiency 2 15.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opiate antagonists naloxone and naltrexone completely blocked morphine-induced suppression of NK activity, whereas naloxone methiodide, a congener that crosses the blood-brain barrier much more slowly than naloxone, produced very little blockade.
Negative_regulation (blocked) of Negative_regulation (suppression) of NK in brain associated with antagonist, narcan, opiate and morphine
1) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.41
The glucocorticoid receptor antagonist Roussel-Uclaf 38486 blocked morphine-induced suppression of NK activity in a dose-responsive fashion.
Negative_regulation (blocked) of Negative_regulation (suppression) of NK associated with antagonist and morphine
2) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.23
Nonetheless, parenteral administration of the sigma receptor ligand BD 1165 blocked (+)-pentazocine-induced suppression of NK activity, while the opiate receptor antagonist naltrexone was ineffective.
Negative_regulation (blocked) of Negative_regulation (suppression) of NK associated with fortral, antagonist, opiate and parenteral administration
3) Confidence 0.20 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862129 Disease Relevance 0 Pain Relevance 0.79
Furthermore, the antagonism of NPY Y1 receptor prevents the conditioned suppression of NK activity, suggesting that the conditioned and unconditioned effects of morphine involve similar mechanisms.
Negative_regulation (prevents) of Negative_regulation (suppression) of NK associated with morphine
4) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.34 Pain Relevance 1.01

General Comments

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