INT54740

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.27
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 99.98 Very High Very High Very High
cocaine 22 99.98 Very High Very High Very High
Dynorphin 49 98.96 Very High Very High Very High
abdominal pain 4 98.60 Very High Very High Very High
Kappa opioid receptor 50 98.16 Very High Very High Very High
Locus ceruleus 2 97.52 Very High Very High Very High
depression 60 96.88 Very High Very High Very High
withdrawal 5 82.16 Quite High
Kinase C 48 81.76 Quite High
Migraine 27 76.72 Quite High
Disease Link Frequency Relevance Heat
Stress 189 99.98 Very High Very High Very High
Anxiety Disorder 112 99.18 Very High Very High Very High
Abdominal Pain 4 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 6 97.24 Very High Very High Very High
Aggression 59 97.16 Very High Very High Very High
Depression 69 96.88 Very High Very High Very High
Pallor 1 96.84 Very High Very High Very High
Vomiting 107 96.52 Very High Very High Very High
Hypertension 8 95.68 Very High Very High Very High
Heart Rate Under Development 5 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some cases, stressors applied pre-partum (which could elevate central CRF release) impair maternal defense [31,32] and CRF neurotransmission may be decreased during lactation to help prevent environmental stressors (acting via CRF) from unduly impairing the defense of offspring.
Positive_regulation (elevate) of Localization (release) of CRF
1) Confidence 0.47 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 1.20 Pain Relevance 0
It has been also been suggested that CRF1-R-induced anxiety-like behavior may be a critical factor for the initiation of stress-induced reinstatement to drug seeking because the animal may act to re-engage drug seeking as a means to relieve the anxiety and/or dysphoria associated with stress-induced CRF release.
Positive_regulation (induced) of Localization (release) of CRF associated with stress and anxiety disorder
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 1.14 Pain Relevance 0.65
This result suggests that the presence of CRH is required for the formation of the diurnal regulation of the HPA axis, but the circadian variation of CRH is not indispensable, at least in rodents.
Positive_regulation (required) of Localization (presence) of CRH
3) Confidence 0.41 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0
It is also known that exposure to cytokines augments the expression and/or secretion of CRH.
Positive_regulation (augments) of Localization (secretion) of CRH associated with cytokine
4) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.22 Pain Relevance 0.12
Infusions of IL-1 induced a significant secretion of hypothalamic CRH (Sapolsky et al. 1987; Berkenbosch et al. 1987).
Positive_regulation (induced) of Localization (secretion) of CRH
5) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.22 Pain Relevance 0.12
stimulate CRH secretion in dissociated hypothalamic culture (Wei et al. 2002).
Positive_regulation (stimulate) of Localization (secretion) of CRH
6) Confidence 0.38 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0.29
For instance, HPA axis overdrive, related to an enhanced secretion of CRH and an impaired negative feedback via GC receptors, is most consistently observed in patients with melancholic depression.
Positive_regulation (enhanced) of Localization (secretion) of CRH associated with depression
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.87 Pain Relevance 0.24
We postulate that cocaine stimulates the release of corticotropin releasing factor and that the cocaine-induced secretion of corticotropin releasing factor increases the amplitude of ACTH pulses, because ACTH pulse frequency was not altered by cocaine.
Positive_regulation (induced) of Localization (secretion) of corticotropin releasing factor associated with cocaine
8) Confidence 0.06 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932162 Disease Relevance 0.05 Pain Relevance 0.48
Stress induces hypothalamic release of Corticotropin Releasing Factor (CRF) [60].
Positive_regulation (induces) of Localization (release) of Corticotropin Releasing Factor associated with stress
9) Confidence 0.05 Published 2005 Journal BMC Med Section Body Doc Link PMC1326207 Disease Relevance 2.92 Pain Relevance 0.62
We postulate that cocaine stimulates the release of corticotropin releasing factor and that the cocaine-induced secretion of corticotropin releasing factor increases the amplitude of ACTH pulses, because ACTH pulse frequency was not altered by cocaine.
Positive_regulation (stimulates) of Localization (release) of corticotropin releasing factor associated with cocaine
10) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932162 Disease Relevance 0.06 Pain Relevance 0.50

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