INT54747

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Context Info
Confidence 0.73
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.69
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
spinal 2
respiratory system 1
nerve 1
sperm 1
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 38 100.00 Very High Very High Very High
opioid receptor 30 100.00 Very High Very High Very High
Enkephalin 25 100.00 Very High Very High Very High
nMDA receptor 5 100.00 Very High Very High Very High
Opioid 17 99.20 Very High Very High Very High
analgesia 4 99.10 Very High Very High Very High
Action potential 2 98.84 Very High Very High Very High
tetrodotoxin 1 97.64 Very High Very High Very High
Endogenous opioid 7 95.20 Very High Very High Very High
substance P 1 93.44 High High
Disease Link Frequency Relevance Heat
Sperm Disorder 8 99.20 Very High Very High Very High
Sprains And Strains 4 93.88 High High
Nociception 3 92.88 High High
Lung Cancer 2 75.00 Quite High
Teratocarcinoma 1 41.52 Quite Low
Tics 5 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the delta-opioid receptor inhibiting [3H]-acetylcholine release should not be located to cholinergic nerve terminals, but rather to interneurons.
Localization (inhibiting) of delta-opioid receptor in nerve associated with opioid receptor
1) Confidence 0.73 Published 1998 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 10198826 Disease Relevance 0 Pain Relevance 0.80
Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor.
Localization (localization) of delta opioid receptor associated with agonist and opioid receptor
2) Confidence 0.71 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16595649 Disease Relevance 0 Pain Relevance 0.20
To determine whether the increases in messenger RNAs were accompanied by an increased synthesis of the respective proteins, we examined the immunoperoxidase localization of N-methyl-D-aspartate receptor and delta opioid receptor antisera.
Spec (examined) Localization (localization) of delta opioid receptor associated with nmda receptor and opioid receptor
3) Confidence 0.65 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219948 Disease Relevance 0 Pain Relevance 0.67
Our findings provide evidence of a local opioid network, that is, the exact anatomical localization of proenkephalin, its functionally active peptide met-enkephalin, and the key processing enzymes as well as corresponding delta opioid receptor, linked to functionally important structures of the respiratory system.
Localization (localization) of delta opioid receptor in respiratory system associated with opioid receptor, enkephalin and opioid
4) Confidence 0.36 Published 2010 Journal Hum. Pathol. Section Abstract Doc Link 20040394 Disease Relevance 0.14 Pain Relevance 0.94
The relevance of intact enkephalin molecule in predominantly delta opioid receptor mediated superoxide anion release.
Localization (release) of delta opioid receptor associated with opioid receptor and enkephalin
5) Confidence 0.12 Published 1995 Journal Neuropeptides Section Title Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.27
Delta opioid receptor on equine sperm cells: subcellular localization and involvement in sperm motility analyzed by computer assisted sperm analyzer (CASA)

Background

Spec (analyzed) Localization (localization) of Delta opioid receptor in sperm associated with sperm disorder and opioid receptor
6) Confidence 0.02 Published 2010 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2901311 Disease Relevance 0.19 Pain Relevance 0.40
Thus suspending mice by the tail evoked a reflex enhancement of spinal mu agonist-induced analgesia that probably involved both the supraspinal release of beta-endorphin (an endogenous epsilon agonist) and the subsequent spinal release of an endogenous delta-receptor agonist in the reflex pathway.
Localization (release) of delta-receptor in spinal associated with agonist and analgesia
7) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932169 Disease Relevance 0.18 Pain Relevance 1.03
Thus suspending mice by the tail evoked a reflex enhancement of spinal mu agonist-induced analgesia that probably involved both the supraspinal release of beta-endorphin (an endogenous epsilon agonist) and the subsequent spinal release of an endogenous delta-receptor agonist in the reflex pathway.
Localization (release) of delta-receptor in spinal associated with agonist and analgesia
8) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932169 Disease Relevance 0.17 Pain Relevance 0.97

General Comments

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