INT54749

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Context Info
Confidence 0.09
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.88
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BTRC) signal transduction (BTRC) nucleus (BTRC)
ligase activity (BTRC) cytoplasm (BTRC)
Anatomy Link Frequency
brains 1
BTRC (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
Morphine 4 99.60 Very High Very High Very High
antagonist 4 98.20 Very High Very High Very High
Opioid 12 97.76 Very High Very High Very High
agonist 4 92.48 High High
opiate 4 91.80 High High
Kappa opioid receptor 3 75.00 Quite High
Central nervous system 3 72.40 Quite High
narcan 3 25.00 Low Low
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 8 91.04 High High
Bordatella Infection 4 84.32 Quite High
Hyperplasia 1 53.84 Quite High
Erythrocytosis 11 50.00 Quite Low
Hypersensitivity 5 46.80 Quite Low
Myelodysplastic Syndromes 15 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Infarction 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta-Trcp binds to Ser 462 within the intracellular part of the receptor and contributes to EPOR ubiquitination in the presence of the hormone.
Beta-Trcp Binding (binds) of
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.05 Pain Relevance 0
The selective mu ligand DAMGO competes with mu binding over 35-fold more potently than kappa 3 binding, whereas morphine shows a 10-fold selectivity.
kappa 3 Binding (binding) of associated with morphine
2) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.22 Pain Relevance 0.57
The binding profiles also distinguish clearly mu from kappa 3 binding.
kappa 3 Binding (binding) of
3) Confidence 0.04 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.22 Pain Relevance 0.57
The selective mu ligand DAMGO competes with mu binding over 35-fold more potently than kappa 3 binding, whereas morphine shows a 10-fold selectivity.
kappa 3 Binding (binding) of associated with morphine
4) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.22 Pain Relevance 0.56
Selective assays reveal a binding distribution of mu (38%), delta (16%) and kappa 3 (43%) opioid receptors.
kappa 3 Binding (binding) of associated with opioid receptor
5) Confidence 0.03 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.17 Pain Relevance 0.47
Tissue homogenates from these brains were analysed for mu1, mu2, delta, kappa1 and kappa3 opioid receptor binding using standard radioligand binding techniques.
kappa3 Spec (analysed) Binding (binding) of in brains associated with opioid receptor
6) Confidence 0.00 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.25
At 4 degrees C mu1, mu2, delta, kappa1 and kappa3 binding remained constant over the 24 hour period.
kappa3 Binding (binding) of
7) Confidence 0.00 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.23
At room temperature mu1, mu2 and delta opioid receptor binding was reduced between 6 and 12 hours, whereas kappa1 and kappa3 binding was reduced after 24 hours.
kappa3 Binding (binding) of associated with opioid receptor
8) Confidence 0.00 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.24

General Comments

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