INT54750

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Context Info
Confidence 0.14
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.99
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BTRC) signal transduction (BTRC) nucleus (BTRC)
ligase activity (BTRC) cytoplasm (BTRC)
Anatomy Link Frequency
C cells 1
BTRC (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
Opioid 9 98.44 Very High Very High Very High
opiate 3 94.96 High High
antagonist 3 90.04 High High
agonist 3 89.12 High High
Morphine 3 85.76 High High
cytokine 8 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.52 Very High Very High Very High
Hyperplasia 2 97.48 Very High Very High Very High
Bordatella Infection 3 93.24 High High
Hypersensitivity 10 87.92 High High
Erythrocytosis 22 50.00 Quite Low
Myelodysplastic Syndromes 30 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Infarction 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that BaF3 cells, expressing a mutated EPOR unable to bind beta-Trcp, are hypersensitive to EPO, suggesting beta-Trcp-mediated ubiquitination represents a negative modulator of EPO-induced cellular proliferation [35].
Neg (unable) Gene_expression (expressing) of beta-Trcp associated with hyperplasia
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.18 Pain Relevance 0
It is interesting that BaF3 cells, expressing a mutated EPOR unable to bind beta-Trcp, are hypersensitive to EPO, suggesting beta-Trcp-mediated ubiquitination represents a negative modulator of EPO-induced cellular proliferation [35].
Neg (unable) Gene_expression (expressing) of beta-Trcp-mediated associated with hyperplasia
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.19 Pain Relevance 0
The sum of the Bmax values in the selective binding assays (370 +/- 39 fmol/mg protein) approximates closely that observed with 3H-diprenorphine, suggesting that mu, delta and kappa 3 sites account for most of the binding.
Gene_expression (account) of kappa 3
3) Confidence 0.06 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.21 Pain Relevance 0.58
In addition to demonstrating that BE(2)-C cells provide a useful model system for studying mu, kappa 3 and delta receptors, these studies confirm that kappa 3 receptors represent a pharmacologically distinct receptor class in this cell line.
Gene_expression (represent) of kappa 3 in C cells
4) Confidence 0.06 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932177 Disease Relevance 0.17 Pain Relevance 0.42
Biochemical and pharmacological characterization of mu, delta and kappa 3 opioid receptors expressed in BE(2)-C neuroblastoma cells.
Gene_expression (expressed) of kappa 3 associated with neuroblastoma and opioid receptor
5) Confidence 0.05 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7932177 Disease Relevance 0.25 Pain Relevance 0.56

General Comments

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