INT54755

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 23
Disease Relevance 2.70
Pain Relevance 7.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
striatum 2
brain stem 2
NG108-15 1
neuron 1
brain 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 541 100.00 Very High Very High Very High
Potency 2 99.92 Very High Very High Very High
agonist 764 99.82 Very High Very High Very High
Enkephalin 15 99.76 Very High Very High Very High
medulla 5 99.56 Very High Very High Very High
Dopamine 19 99.36 Very High Very High Very High
Dynorphin 8 99.16 Very High Very High Very High
Neurotransmitter 19 99.08 Very High Very High Very High
Catecholamine 3 98.12 Very High Very High Very High
antagonist 153 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 60 99.96 Very High Very High Very High
Parkinson's Disease 12 97.52 Very High Very High Very High
Cancer 77 94.40 High High
Necrosis 8 93.84 High High
Dyskinesias 4 93.52 High High
Drug Induced Neurotoxicity 2 88.52 High High
Anxiety Disorder 10 85.28 High High
Urological Neuroanatomy 2 81.84 Quite High
Glioma 7 81.16 Quite High
Neuroblastoma 28 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in hindbrain, A2AR-stimulated [35S]GTPgammaS binding decreases during postnatal development in parallel with the decrease in A2AR levels, whereas [35S]GTPgammaS binding stimulated by other neurotransmitter receptor systems increases in parallel with basal [35S]GTPgammaS binding.
Negative_regulation (decrease) of A2AR in hindbrain associated with neurotransmitter
1) Confidence 0.58 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.34
These studies 1) demonstrate the functional measurement of A2AR-G protein coupling in native tissue for the first time, 2) demonstrate that A2AR are coupled to G proteins throughout postnatal development, and 3) describe developmental increases and decreases in functional A2AR in brain.
Negative_regulation (decreases) of A2AR in brain
2) Confidence 0.58 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.21
Unlike in the brainstem, castration caused a decrease in alpha2A-AR mRNA in the cortex and testosterone up-regulated this mRNA in the cortical region.
Negative_regulation (decrease) of alpha2A-AR in brainstem associated with medulla
3) Confidence 0.45 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965356 Disease Relevance 0.08 Pain Relevance 0.39
To assess the ability of A2A receptor blockade to normalize certain of these kinases and thus benefit motor dysfunction, the palliative and prophylactic effects of the selective antagonist KW6002 were first evaluated in rodent and primate models.
Negative_regulation (blockade) of A2A associated with antagonist and palliative
4) Confidence 0.43 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.47 Pain Relevance 0.31
However, for A2AR the decrease in receptor density is the overriding factor.
Negative_regulation (decrease) of A2AR
5) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.31
The results suggest that drugs capable of selectively blocking adenosine A2A receptors could confer therapeutic benefit to L-dopa-treated parkinsonian patients and warrant further evaluation in phase II studies.
Negative_regulation (blocking) of A2A associated with parkinson's disease and adenocard
6) Confidence 0.42 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.59 Pain Relevance 0.21
Studies in DA-denervated rats suggest that blockade of adenosine A2A receptors might be used in PD.
Negative_regulation (blockade) of A2A associated with adenocard
7) Confidence 0.41 Published 1999 Journal Neurology Section Abstract Doc Link 10331698 Disease Relevance 0.07 Pain Relevance 0.46
Age-related loss of mRNA encoding adenosine A2 receptor in the rat striatum.
Negative_regulation (loss) of adenosine A2 receptor in striatum associated with adenocard
8) Confidence 0.35 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8233082 Disease Relevance 0 Pain Relevance 0.68
In the old striatum, the levels of adenosine A2 receptor mRNA and adenosine A2 binding sites were reduced by 32% and 20%, respectively.
Negative_regulation (reduced) of adenosine A2 receptor mRNA in striatum associated with adenocard
9) Confidence 0.34 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8233082 Disease Relevance 0 Pain Relevance 0.50
In the unilateral 6-hydroxydopamine-lesioned rat model of Parkinson's disease, blockade of A2A receptors facilitates L-dopa-induced turning behavior by antagonism of A2A transmission, which is increased after dopamine depletion.
Negative_regulation (blockade) of A2A associated with dopamine and disease
10) Confidence 0.34 Published 2003 Journal Neurology Section Abstract Doc Link 14663008 Disease Relevance 0.10 Pain Relevance 0.31
Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats.
Negative_regulation (blockade) of A2A associated with dopamine, dynorphin and enkephalin
11) Confidence 0.30 Published 2002 Journal Synapse Section Title Doc Link 11954048 Disease Relevance 0.09 Pain Relevance 0.76
Longer exposure of NECA (20 min) to the NTS slices resulted in inhibition of the 5-HT release, probably caused by quick desensitization of the A2AR (15 min) and subsequent involvement of the A1R [65].
Negative_regulation (desensitization) of A2AR
12) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.26
Stable transfection of a GRK2Lys220Arg mutant in NG108-15 cells reduced desensitization of the A2AR by 50% following a 30-min treatment with the adenosine agonist NECA.
Negative_regulation (desensitization) of A2AR in NG108-15 associated with adenocard and agonist
13) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.19 Pain Relevance 0.20
This pretreatment did not affect the agonist-induced desensitization of the A2AR.
Negative_regulation (desensitization) of A2AR associated with agonist
14) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.14 Pain Relevance 0.27
The role of GRK2 in agonist-induced phosphorylation and subsequent desensitization of A2AR and A2BR was thoroughly investigated by Kelly and co-workers.
Negative_regulation (desensitization) of A2AR associated with agonist
15) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.16
Using a tissue preparation, Conti et al. investigated whether prolonged exposure of A2AR to the non-selective agonist NECA, or to the selective A2AR agonists CGS21680 and 2HE-NECA, influenced A2AR desensitization.
Spec (whether) Negative_regulation (desensitization) of A2AR associated with agonist
16) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.12 Pain Relevance 0.23
Cells exposed to NECA showed a rapid desensitization of A2AR-stimulated adenylyl cyclase activity with no obvious difference between pretreatment of 30 min or 24 h.
Negative_regulation (desensitization) of A2AR
17) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.16 Pain Relevance 0.29
However, the resensitization of the A2AR upon agonist removal was abolished in the presence of ConA or sucrose.
Negative_regulation (resensitization) of A2AR associated with agonist
18) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.13 Pain Relevance 0.27
In this study, the functionality of A1Rs was not affected by NMDA preconditioning, but this treatment promoted A2AR desensitization in concert with A1R activation [83].
Negative_regulation (desensitization) of A2AR
19) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.16 Pain Relevance 0.53
Treatment with AS-ODN significantly reduced the levels of alpha2A-AR mRNA in the brain stem.
Negative_regulation (reduced) of alpha2A-AR in brain stem
20) Confidence 0.12 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.09 Pain Relevance 0.19

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