INT5476

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 4.01
Pain Relevance 10.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gabbr1) plasma membrane (Gabbr1) transcription factor binding (Gabbr1)
cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Anatomy Link Frequency
spinal cord 2
spinal 1
neurons 1
olfactory bulb 1
dorsal horn 1
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 433 100.00 Very High Very High Very High
addiction 40 100.00 Very High Very High Very High
withdrawal 15 100.00 Very High Very High Very High
Ventral tegmentum 14 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
agonist 303 99.96 Very High Very High Very High
qutenza 2 99.92 Very High Very High Very High
antinociception 11 99.44 Very High Very High Very High
Enkephalin 2 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 25 99.64 Very High Very High Very High
Neurodegenerative Disease 31 99.12 Very High Very High Very High
Nociception 102 97.80 Very High Very High Very High
Pain 78 92.76 High High
Overactive Bladder 3 91.96 High High
Cognitive Disorder 23 90.56 High High
Epilepsy 12 89.56 High High
Nicotine Addiction 5 88.68 High High
Hyperalgesia 19 88.36 High High
Convulsion 6 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABAB receptors are also highly concentrated in the superficial dorsal horn, predominantly on afferent terminals of sensory neurons located in the dorsal root ganglia (DRG) [6-9].
Regulation (concentrated) of GABAB in dorsal horn associated with dorsal horn
1) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.35 Pain Relevance 0.59
To clarify the specific contribution of GABAB receptors on peripheral terminals, we performed electrophysiological recordings on peripheral polymodal C-fiber nociceptors and A?
Regulation (contribution) of GABAB in nociceptors associated with c fibre and nociceptor
2) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.06 Pain Relevance 0.43
Recent studies suggest that gamma-aminobutyric acid type B (GABA(B)) receptors located on dopaminergic cells in the ventral tegmental area (VTA) regulate mesolimbic dopaminergic (A10) activity.
Regulation (regulate) of gamma-aminobutyric acid type B in ventral associated with ventral tegmentum and gaba
3) Confidence 0.39 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11755254 Disease Relevance 0 Pain Relevance 0.76
As we will see now, such a complex structure offers a number of possibilities to modulate GABAB receptor function.


Spec (possibilities) Regulation (modulate) of GABAB receptor
4) Confidence 0.37 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.15
The effects of chronic morphine administration (dependence) and naloxone-induced withdrawal on cerebral GABAB receptor and its signal transduction system were examined.
Regulation (effects) of GABAB receptor associated with addiction, narcan, withdrawal and morphine
5) Confidence 0.30 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950321 Disease Relevance 0 Pain Relevance 0.51
The effect of GABAB PAMs on drug dependence and reinforcement has therefore been studied recently as a potential alternative to baclofen.
Regulation (effect) of GABAB associated with drug dependence and addiction
6) Confidence 0.27 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0.62 Pain Relevance 0.63
This study revealed that the GABAB2 HD was required and sufficient for CGP7930 action.
Regulation (required) of GABAB2
7) Confidence 0.27 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.25
The
GABAB1a and GABAB1b isoforms constitute two
independently regulated receptor subtypes, GABAB(1a,2) and
GABAB(1b,2), whereas the functional role of several secreted
GABAB1 isoforms remains unclear
(1,
14-17).

Neg (independently) Regulation (regulated) of GABAB
8) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.33 Pain Relevance 0.11
The
GABAB1a and GABAB1b isoforms constitute two
independently regulated receptor subtypes, GABAB(1a,2) and
GABAB(1b,2), whereas the functional role of several secreted
GABAB1 isoforms remains unclear
(1,
14-17).

Neg (independently) Regulation (regulated) of GABAB
9) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0.33 Pain Relevance 0.11
In the above experiments, RSDP effects on GABAB(1a,2) autoreceptors
or postsynaptic GABAB(1a,2) receptors may remain undetected due to
the concomitant action of GABAB(1b,2) receptors at GABAergic
terminals and postsynaptic sites. 
Regulation (effects) of GABAB associated with gabaergic
10) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576543 Disease Relevance 0 Pain Relevance 0.16
The antinociceptive effect of baclofen could be attributed to the effect of baclofen on GABA B receptors producing presynaptic inhibition of primary nociceptive afferents in the dorsal horn of the spinal cord.
Regulation (effect) of GABA B in spinal cord associated with nociception, gaba, dorsal horn, antinociceptive and spinal cord
11) Confidence 0.26 Published 1993 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 8276493 Disease Relevance 0.44 Pain Relevance 0.91
To identify the mode of action of CGP7930, Binet and colleagues studied its effect on various combinations of wild-type and chimeric GABAB subunits, and took advantage of the agonist activity of this molecule in their assay [3].
Regulation (effect) of GABAB associated with agonist
12) Confidence 0.24 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.35
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.
Regulation (responses) of GABAB
13) Confidence 0.23 Published 2004 Journal J. Neurosci. Section Title Doc Link 15240800 Disease Relevance 0.17 Pain Relevance 0.14
To our surprise and in contrast to GABAB(1)-/- mice, we still detect atypical electrophysiological GABAB responses in hippocampal slices of GABAB(2)-/- mice.
Regulation (responses) of GABAB
14) Confidence 0.23 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15240800 Disease Relevance 0.27 Pain Relevance 0.16
The present study was designed to investigate the modulatory effects of blockade of spinal GABAA and GABAB receptors on antinociception induced by supraspinally administered mu- and epsilon-opioid receptor agonists.
Spec (investigate) Regulation (effects) of GABAB in spinal associated with antinociception, agonist and opioid receptor
15) Confidence 0.23 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8832215 Disease Relevance 0 Pain Relevance 0.88
We examined the effects of the GABAB receptor agonist baclofen and the mu opioid receptor agonist DAGO on postsynaptic currents evoked by minimal stimulation of inhibitory fibers (meIPSCs) in area CA3.
Spec (examined) Regulation (effects) of GABAB receptor associated with mu opioid receptor and agonist
16) Confidence 0.20 Published 1993 Journal Neuron Section Abstract Doc Link 8274277 Disease Relevance 0.07 Pain Relevance 0.34
Whatever, these data revealed that it is possible to positively modulate GABAB receptor function with small molecules.
Spec (possible) Regulation (modulate) of GABAB receptor
17) Confidence 0.16 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.25
These results indicate that blockade of both GABAA and GABAC receptors is necessary to attenuate GABA inhibition of retinal rhythms with, again, no dependence on GABAB receptors.
Neg (no) Regulation (dependence) of GABAB associated with addiction and gaba
18) Confidence 0.13 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.74
Estrogen rapidly attenuates a GABAB response in hypothalamic neurons.
Regulation (response) of GABAB in neurons associated with enkephalin
19) Confidence 0.10 Published 1996 Journal Neuroendocrinology Section Title Doc Link 8857605 Disease Relevance 0 Pain Relevance 0.43
GABA acts on 2 classes of receptors-GABAA and GABAB.
Regulation (acts) of GABAB associated with gaba
20) Confidence 0.09 Published 1992 Journal Br J Urol Section Abstract Doc Link 1310630 Disease Relevance 0.18 Pain Relevance 0.50

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