INT54763

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 82
Total Number 86
Disease Relevance 63.27
Pain Relevance 12.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 4
macrophage 3
brain 3
colon 2
blood 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1328 100.00 Very High Very High Very High
cytokine 966 100.00 Very High Very High Very High
chemokine 141 100.00 Very High Very High Very High
ischemia 23 100.00 Very High Very High Very High
Neuropeptide 2 99.76 Very High Very High Very High
Osteoarthritis 396 99.64 Very High Very High Very High
Pain 71 99.00 Very High Very High Very High
Inflammatory marker 204 98.96 Very High Very High Very High
Spinal cord 27 98.68 Very High Very High Very High
rheumatoid arthritis 480 97.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1698 100.00 Very High Very High Very High
Cancer 1410 100.00 Very High Very High Very High
Adhesions 66 100.00 Very High Very High Very High
Coronary Artery Disease 49 100.00 Very High Very High Very High
Thrombosis 13 100.00 Very High Very High Very High
Rheumatoid Arthritis 965 99.88 Very High Very High Very High
Congenital Anomalies 24 99.88 Very High Very High Very High
Death 227 99.80 Very High Very High Very High
Cognitive Disorder 188 99.80 Very High Very High Very High
Aging 122 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After additional adjustment for other markers, only the association between IL-6 and poor outcome remained independently significant (OR: 2.4, 95% CI: 1.3–4.5).
IL-6 Binding (association) of
1) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.75 Pain Relevance 0
We extracted data from logistic regression models reporting the association between IL-6 and poor outcome or death after stroke, and the degree of adjustment for age, stroke severity, and other potential confounders.
IL-6 Binding (association) of associated with stroke and death
2) Confidence 0.48 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.98 Pain Relevance 0.08
Osteoporosis, a common systemic manifestation of RA, is also linked with IL-6.
IL-6 Binding (linked) of associated with rheumatoid arthritis and osteoporosis
3) Confidence 0.43 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.86 Pain Relevance 0.11
Once IL-6 binds its receptor and gp130 homodimerization occurs, a signalling cascade is triggered.
IL-6 Binding (binds) of
4) Confidence 0.43 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.75 Pain Relevance 0.16
This might recognize in IL-6 a credible candidate as a cooperating factor.
IL-6 Spec (might) Binding (recognize) of
5) Confidence 0.42 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 1.33 Pain Relevance 0.42
Infusion of IL-6 has also been shown to cause pulmonary vascular thrombosis and vessel occlusion, indicating prothrombotic and proinflammatory interactions with circulating cells [22,23].
IL-6 Binding (interactions) of in circulating cells associated with thrombosis
6) Confidence 0.37 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 2.11 Pain Relevance 0.11
Ci/ml of [3H] thymidine with IL-6, sIL-6-R, or both (100 ng/ml of each).
IL-6 Binding (thymidine) of
7) Confidence 0.37 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.11 Pain Relevance 0
After three washes, a conjugate of polyclonal IL-6 antibody and horseradish peroxidase was added and incubated for 2 h at room temperature.
IL-6 Binding (conjugate) of
8) Confidence 0.37 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.09 Pain Relevance 0
Aging increases IL-6 in plasma and brain
IL-6 Binding (brain) of in plasma associated with aging
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.41 Pain Relevance 0.15
Aging increases IL-6 in plasma and brain
IL-6 Binding (plasma) of in plasma associated with aging
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.41 Pain Relevance 0.15
We identified four relevant studies(Table 5) [27]–[30] that yielded, for the association between IL-6 and poor outcome, 1,037 patients, and IL-6 and death 1,122 patients.
IL-6 Binding (association) of associated with death
11) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.63 Pain Relevance 0
Blood samples for IL-6, CRP, and fibrinogen were transported to the laboratory on water ice, centrifuged to obtain serum and EDTA-anticoagulated plasma, and stored at ?
IL-6 Binding (samples) of in Blood
12) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.87 Pain Relevance 0.06
A systematic search of the literature revealed that previous studies that had looked at the potential association between interleukin-6 levels and outcome after stroke had found similar results.
interleukin-6 Binding (association) of associated with stroke
13) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2730573 Disease Relevance 1.07 Pain Relevance 0.19
We identified four relevant studies(Table 5) [27]–[30] that yielded, for the association between IL-6 and poor outcome, 1,037 patients, and IL-6 and death 1,122 patients.
IL-6 Binding (association) of associated with death
14) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.61 Pain Relevance 0
After adjustment for the six simple variables, the associations between IL-6, CRP, and white cell count remained statistically significant (Table 2).


IL-6 Binding (associations) of
15) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.65 Pain Relevance 0
In this large cohort of stroke patients, we found that higher levels of IL-6, CRP, and white cell count were independently and significantly associated with poor outcome and death at 6 mo after stroke.
IL-6 Binding (associated) of associated with stroke and death
16) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.89 Pain Relevance 0.06
However, the mechanisms underlying this association between IL-6 and cognitive vulnerability remain unclear.


IL-6 Binding (association) of associated with cognitive disorder
17) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2678193 Disease Relevance 1.09 Pain Relevance 0.15
We performed a systematic review of the literature and meta-analysis of the association between interleukin-6 and poor outcome after stroke to place our study in the context of previous research.
interleukin-6 Binding (association) of associated with stroke
18) Confidence 0.36 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2730573 Disease Relevance 0.76 Pain Relevance 0.18
Previous studies have shown that innate immune dysfunction, associated with absence of interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor, IL-1RI, and IL-18, leads to obesity [14]–[19].
IL-6 Neg (absence) Binding (absence) of in macrophage associated with obesity
19) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 1.65 Pain Relevance 0.11
We found indeed that the IL-6/gp130 ligand-receptor complex induced heat hypersensitivity both in vitro and in vivo.
IL-6 Binding (ligand) of associated with hypersensitivity
20) Confidence 0.35 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 1.27 Pain Relevance 0.99

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