INT54776

Context Info Confidence 0.42 First Reported 1993 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 0 Pain Relevance 4.45

plasma membrane (Cckbr) nucleus (Cckbr) cytoplasm (Cckbr) signal transducer activity (Cckbr)

Anatomy Link Frequency cerebral cortex 1 parietal cell 1 cortex 1 Cckbr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Cholecystokinin 29 100.00 opioid receptor 4 100.00 Opioid 16 99.80 cerebral cortex 3 99.68 withdrawal 3 99.32 Morphine 7 98.88 Analgesic 2 97.72 tolerance 2 97.04 analgesia 3 96.60 Kappa opioid receptor 2 96.56

Disease Link Frequency Relevance Heat Duodenal Ulcer 1 25.00 Disease 1 5.00 Ulcers 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results demonstrate an estrogen regulation of the MOP receptor and a protein-protein interaction between CCK1 receptor and MOP receptor.

CCK1 receptor Binding (interaction) of associated with opioid

1) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16472782 Disease Relevance 0 Pain Relevance 1.10

In contrast, L-365,260 binds to the isolated canine parietal cell gastrin receptor weakly, and without stereoselectivity.

gastrin receptor Binding (binds) of in parietal cell

2) Confidence 0.35 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510013 Disease Relevance 0 Pain Relevance 0.26

Compound 7a (S-0509) showed remarkable affinity for the CCK-B/gastrin receptor and a subtype selectivity profile in vitro.

CCK-B Binding (affinity) of

3) Confidence 0.35 Published 1997 Journal Bioorg. Med. Chem. Section Abstract Doc Link 9313871 Disease Relevance 0 Pain Relevance 0.23

CCK receptor binding in rat cerebral cortex never differed from the values obtained from animals implanted with saline-releasing minipumps.

CCK receptor Binding (binding) of in cerebral cortex associated with cerebral cortex and cholecystokinin

4) Confidence 0.33 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7936125 Disease Relevance 0 Pain Relevance 1.32

Estrogen and CCK1 receptor modification of mu-opioid receptor binding in the cortex of female rats.

CCK1 receptor Binding (binding) of in cortex associated with opioid receptor

5) Confidence 0.33 Published 2006 Journal Brain Res. Section Title Doc Link 16472782 Disease Relevance 0 Pain Relevance 1.19

All the title compounds were devoid of significant affinity for both CCK-A and CCK-B receptors, while some of them bound with nanomolar affinity and high selectivity for kappa-opioid receptors.

CCK-B Binding (affinity) of associated with kappa opioid receptor

6) Confidence 0.23 Published 1996 Journal J. Med. Chem. Section Abstract Doc Link 8632410 Disease Relevance 0 Pain Relevance 0.34

General Comments

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