INT5481

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 1.30
Pain Relevance 7.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
hypothalamus 1
pituitary 1
Bands 1
cerebellum 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 84 100.00 Very High Very High Very High
orphanin 13 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
Catecholamine 8 99.88 Very High Very High Very High
Enkephalin 17 99.80 Very High Very High Very High
Hippocampus 6 99.40 Very High Very High Very High
antagonist 13 99.32 Very High Very High Very High
opiate 19 98.64 Very High Very High Very High
Substantia nigra 3 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nevus 31 99.20 Very High Very High Very High
Melanoma 154 88.84 High High
Cancer 13 85.64 High High
Neuroblastoma 3 83.44 Quite High
Colon Cancer 5 75.00 Quite High
INFLAMMATION 1 64.20 Quite High
Apoptosis 3 62.88 Quite High
Adhesions 47 56.44 Quite High
Mental Disorders 18 53.04 Quite High
Sunburn 14 43.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyr-MIF-1, at a dose of 1 mg/kg IP, significantly augmented benzodiazepine binding in cortex and hippocampus but not in cerebellum, hypothalamus, or pons-medulla.
Tyr Binding (binding) of in hypothalamus associated with medulla and hippocampus
1) Confidence 0.47 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2893390 Disease Relevance 0 Pain Relevance 0.40
Tyr-MIF-1 augments benzodiazepine receptor binding in vivo.
Tyr Binding (binding) of
2) Confidence 0.47 Published 1987 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 2893390 Disease Relevance 0 Pain Relevance 0.38
Dextrorphan and the mu specific peptide morphiceptin (Tyr-Pro-Phe-Pro-CO-NH2) do not bind to the site.
Tyr Neg (not) Binding (bind) of
3) Confidence 0.47 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3000378 Disease Relevance 0.24 Pain Relevance 0.49
Dimeric analogues of the inactive enkephalin fragment Tyr-D-Ala-Gly were synthesized by cross-linking with alkanediamine at the C-terminus.
Tyr Binding (cross-linking) of associated with enkephalin
4) Confidence 0.36 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3039993 Disease Relevance 0 Pain Relevance 0.37
SFP was purified by affinity chromatography using Suc-Tyr-D-Leu-D-Val-pNA as the bound ligand.
Tyr Binding (bound) of
5) Confidence 0.35 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19797870 Disease Relevance 0 Pain Relevance 0.31
These findings can be interpreted to indicate that the mode of receptor binding of H-Tyr-D-Orn-Phe-Asp-NH2 is identical with that of dermorphin, but differs from that of beta-casomorphins.
Tyr Binding (binding) of
6) Confidence 0.35 Published 1987 Journal J. Med. Chem. Section Abstract Doc Link 2822930 Disease Relevance 0 Pain Relevance 0.31
Binding of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) to mu and delta opiate receptors was compared with other putative opiate antagonist peptides by displacement of iodinated ligands selective for mu (DAGO, FK33824, and morphiceptin) and delta (DPDPE) receptors.
Tyr Binding (Binding) of associated with antagonist and opiate
7) Confidence 0.35 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2880352 Disease Relevance 0 Pain Relevance 0.40
Catecholamines also bound to the mu opiate receptor agonist morphiceptin (Tyr-Pro-Phe-Pro-NH2).
Tyr Binding (bound) of associated with catecholamine, agonist and opioid receptor 1
8) Confidence 0.35 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 3607522 Disease Relevance 0 Pain Relevance 1.34
Further investigation of the TYR and CDKN2A/MTAP loci in families segregating CDKN2A mutations will allow assessment of whether common variants of these genes also modify penetrance of CDKN2A deleterious mutations.
TYR Binding (investigation) of
9) Confidence 0.23 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 0.76 Pain Relevance 0.37
There exist a pi-cation interaction between Tyr-104 and Pro-1.
Tyr Binding (interaction) of
10) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The Viterbi program designed the tripeptide Trp-Tyr-Tyr as the sequence with possible binding affinity to SPG-40.
Tyr Binding (affinity) of
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
There exist a pi-cation interaction between Arg-178 and Tyr-7.
Tyr Binding (interaction) of
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The Viterbi program designed the tripeptide Trp-Tyr-Tyr as the sequence with possible binding affinity to SPG-40.
Tyr Binding (affinity) of
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The known inhibitor Tyr-Pro-Tyr binding affinity for the target protein was determined as ?
Tyr Binding (affinity) of
14) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The known inhibitor Tyr-Pro-Tyr binding affinity for the target protein was determined as ?
Tyr Binding (affinity) of
15) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The binding of 125I-labelled Tyr-Ala-hexarelin to membrane-binding sites is a saturable and reversible process, depending on incubation time and pH of the buffer.
Tyr-Ala-hexarelin Binding (binding) of
16) Confidence 0.18 Published 1998 Journal J. Endocrinol. Section Abstract Doc Link 9614363 Disease Relevance 0 Pain Relevance 0.24
Tyr-MIF-1, at a dose of 1 mg/kg IP, significantly augmented benzodiazepine binding in cortex and hippocampus but not in cerebellum, hypothalamus, or pons-medulla.
Tyr Binding (binding) of in cerebellum associated with medulla and hippocampus
17) Confidence 0.16 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2893390 Disease Relevance 0 Pain Relevance 0.40
Receptor activity is sensitive to trypsin and phospholipase C digestion, suggesting that protein and phospholipids are essential for the binding of 125I-labelled Tyr-Ala-hexarelin.
Tyr-Ala-hexarelin Binding (binding) of
18) Confidence 0.13 Published 1998 Journal J. Endocrinol. Section Abstract Doc Link 9614363 Disease Relevance 0 Pain Relevance 0.39
The binding of 125I-labelled Tyr-Ala-hexarelin to pituitary and hypothalamic membranes was displaced in a dose-dependent manner by different unlabelled synthetic peptidyl (Tyr-Ala-hexarelin, GHRP2, hexarelin, GHRP6) and non-peptidyl (MK 0677) sGHS.
Tyr-Ala-hexarelin Binding (binding) of in pituitary
19) Confidence 0.11 Published 1998 Journal J. Endocrinol. Section Abstract Doc Link 9614363 Disease Relevance 0 Pain Relevance 0.40
Bands at 250, 130 and 100 kDa that displayed a consistent increase in intensity (indicating either an increase in Tyr phosphorylation or a binding to such a protein in the immunoprecipitate) after stretch were subjected mass spectrometric analysis.
Tyr Binding (binding) of in Bands
20) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.06 Pain Relevance 0

General Comments

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