INT54823

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.61
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
arms 1
platelets 1
stomach 1
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 92 95.60 Very High Very High Very High
substance P 1 93.36 High High
cINOD 11 93.00 High High
Lasting pain 1 91.44 High High
Opioid 3 88.80 High High
Inflammation 3 86.00 High High
Pain 4 84.16 Quite High
Arthritis 1 82.52 Quite High
Antinociceptive 5 79.20 Quite High
Central nervous system 1 76.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 4 95.68 Very High Very High Very High
Pain 4 91.44 High High
Cancer 1 91.28 High High
Thrombosis 2 90.08 High High
INFLAMMATION 7 86.00 High High
Arthritis 2 82.52 Quite High
Death 4 77.68 Quite High
Myocardial Infarction 10 54.56 Quite High
Acute Coronary Syndrome 7 44.08 Quite Low
Hemorrhage 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an effort to develop drugs with a safer profile for the stomach, a new form of cyclooxygenase was discovered.
Phosphorylation (form) of cyclooxygenase in stomach
1) Confidence 0.51 Published 2008 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 19075637 Disease Relevance 0.61 Pain Relevance 0.56
The several proposed mechanisms of action, involving serotoninergic, catecholaminergic, Ca2+ fluxes, protein phosphorylation, beta-endorphin production, cyclooxygenase inhibition and histamine interference are also reviewed.
Phosphorylation (phosphorylation) of cyclooxygenase
2) Confidence 0.27 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942319 Disease Relevance 0.18 Pain Relevance 0.68
To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A2 by cyclooxygenase in the platelets and the release of ADP from dense platelet granules.
Phosphorylation (formation) of cyclooxygenase in platelets
3) Confidence 0.17 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.07 Pain Relevance 0.15
In addition to inhibiting cyclooxygenase (COX) activity, this includes interfering with glucose metabolism through both arms of the pentose phosphate pathways and energy production via glycolysis and oxidative phosphorylation.
Phosphorylation (phosphorylation) of cyclooxygenase in arms
4) Confidence 0.16 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10844092 Disease Relevance 0.76 Pain Relevance 0.76

General Comments

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