INT54834

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Context Info
Confidence 0.72
First Reported 1994
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 13.50
Pain Relevance 9.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)
Anatomy Link Frequency
chondrocytes 8
cartilage 5
PSC 4
joints 4
tendon 3
Col2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 362 99.76 Very High Very High Very High
Inflammation 298 99.74 Very High Very High Very High
Snapping jaw 16 99.68 Very High Very High Very High
metalloproteinase 350 99.48 Very High Very High Very High
anesthesia 9 99.38 Very High Very High Very High
Potency 99 99.16 Very High Very High Very High
cINOD 23 98.86 Very High Very High Very High
cytokine 216 98.54 Very High Very High Very High
Arthritis 767 98.36 Very High Very High Very High
Osteoarthritis 438 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 318 99.74 Very High Very High Very High
Temporomandibular Joint Syndrome 16 99.68 Very High Very High Very High
Hypoxia 76 99.12 Very High Very High Very High
Chondrosarcoma 12 99.12 Very High Very High Very High
Aging 47 99.04 Very High Very High Very High
Arthritis 850 98.36 Very High Very High Very High
Osteoarthritis 457 98.28 Very High Very High Very High
Injury 61 97.84 Very High Very High Very High
Arthralgia 9 97.56 Very High Very High Very High
Osteoporosis 15 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, type II collagen synthesis of the mandibular condyle is restricted to its upper area.
Gene_expression (synthesis) of type II collagen in upper
1) Confidence 0.72 Published 2000 Journal J. Craniofac. Genet. Dev. Biol. Section Abstract Doc Link 11321599 Disease Relevance 0.23 Pain Relevance 0.13
Type II collagen synthesis of the fossal cartilage seems to increase as a function of age.
Gene_expression (synthesis) of Type II collagen in cartilage
2) Confidence 0.72 Published 2000 Journal J. Craniofac. Genet. Dev. Biol. Section Abstract Doc Link 11321599 Disease Relevance 0.21 Pain Relevance 0.13
All drugs except tiaprofenic acid decreased type II collagen synthesis by at least 40% at 100 micrograms/ml.
Gene_expression (synthesis) of type II collagen
3) Confidence 0.67 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942329 Disease Relevance 0.37 Pain Relevance 0.23
Treatment with certain nonsteroidal anti-inflammatory drugs could exacerbate cartilage destruction by impairing the synthesis of cartilage matrix proteins, type II collagen and proteoglycan.
Gene_expression (synthesis) of type II collagen in cartilage associated with inflammation and cinod
4) Confidence 0.67 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942329 Disease Relevance 0.35 Pain Relevance 0.15
Effects of certain antiarthritic agents on the synthesis of type II collagen and glycosaminoglycans in rat chondrosarcoma cultures.
Gene_expression (synthesis) of type II collagen associated with chondrosarcoma
5) Confidence 0.67 Published 1994 Journal Agents Actions Section Title Doc Link 7942329 Disease Relevance 0.37 Pain Relevance 0.23
Growth and type-II collagen expression in the glenoid fossa of the temporomandibular joint during altered loading: a study in the rat.
Gene_expression (expression) of type-II collagen in glenoid fossa associated with snapping jaw
6) Confidence 0.65 Published 1996 Journal Eur J Orthod Section Title Doc Link 8746172 Disease Relevance 0.10 Pain Relevance 0.10
The distribution of type I and II collagen synthesis in the temporomandibular joint (TMJ) area of 1- to 28-day-old rats was studied after hybridization with probes to pro alpha1(I) and pro alpha1(II) collagen mRNA, and stain intensity through the various cartilaginous zones of the mandibular condyle and other areas of TMJ was assessed.
Gene_expression (synthesis) of II collagen in mandibular condyle associated with snapping jaw
7) Confidence 0.63 Published 2000 Journal J. Craniofac. Genet. Dev. Biol. Section Abstract Doc Link 11321599 Disease Relevance 0.36 Pain Relevance 0.36
The presence of type-II collagen is obviously not regulated only by compressive forces but probably also by tension loading.
Gene_expression (presence) of type-II collagen
8) Confidence 0.58 Published 1996 Journal Eur J Orthod Section Abstract Doc Link 8746172 Disease Relevance 0.17 Pain Relevance 0.17
Many elements are involved in this particular biomechanical function, but a main one is the presence of chondrocytes producing type II collagen [4], [11].
Gene_expression (producing) of type II collagen in chondrocytes
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0.63 Pain Relevance 0
The numbers of cells in the clusters decreased over time, whereas type II collagen and GAG production increased (Fig. 3).
Gene_expression (production) of type II collagen
10) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
We find that chondrocytes produced type II collagen earlier than did MSCs, and the repaired insertion had a slightly stronger load-to-failure at 30 days than that produced by the MSCs.
Gene_expression (produced) of type II collagen in chondrocytes
11) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
However, the type II collagen and GAG production in insertions repaired with chondrocytes and MSCs was the same 45 days post-repair.
Gene_expression (production) of type II collagen in chondrocytes
12) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
First, neo-enthesis production at 15, 30 and 45 days was assessed by measuring type II collagen production at the bone-tendon junction, the GAG content and cell deposition (magnification ×25) (table 1, first three columns).
Gene_expression (production) of type II collagen in tendon
13) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
The effects of antiarthritic agents on type II collagen and glycosaminoglycan synthesis were examined in rat chondrosarcoma cultures.
Gene_expression (synthesis) of type II collagen associated with chondrosarcoma
14) Confidence 0.52 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942329 Disease Relevance 0.35 Pain Relevance 0.19
Keratan sulfate and type II collagen were expressed in cartilage of rats before strenuous running and were still present at 3 weeks after 15 km of strenuous running.
Gene_expression (expressed) of type II collagen in cartilage
15) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374454 Disease Relevance 0 Pain Relevance 0
Histological scores (1 to 4) were given for each of the following criteria: 1) the percentage contact between bone and tendon with type II collagen production, 2) type II collagen organization, 3) chondrocyte organization and 4) GAG production (table 1).
Gene_expression (production) of type II collagen in tendon
16) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
On day 0 under ether anesthesia, the experimental groups were immunized with 0.5 mg native chick collagen II (CII) solubilized in 0.1 M acetic acid and emulsified in Freund's incomplete adjuvant.
Gene_expression (immunized) of collagen II in CII associated with anesthesia
17) Confidence 0.42 Published 2006 Journal Arch. Toxicol. Section Abstract Doc Link 16609887 Disease Relevance 0.56 Pain Relevance 0.59
Chondrocytes are the natural cells of the enthesis and can produce type II collagen, the major promoter of anchorage.
Gene_expression (produce) of type II collagen in Chondrocytes
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
Histological scores (1 to 4) were given for each of the following criteria: 1) the percentage contact between bone and tendon with type II collagen production, 2) type II collagen organization, 3) chondrocyte organization and 4) GAG production (table 1).
Gene_expression (organization) of type II collagen in tendon
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
After 3 weeks these cells had differentiated into cells expressing chondrocytic phenotype (Collagen II and Sox-9).
Gene_expression (expressing) of Collagen II
20) Confidence 0.19 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18853431 Disease Relevance 0.34 Pain Relevance 0.10

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