INT54836

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Context Info
Confidence 0.30
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.68
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph node 2
thyroid 2
face 1
body 1
RHCE (Homo sapiens)
Pain Link Frequency Relevance Heat
Dysuria 2 94.32 High High
carpal tunnel syndrome 1 93.40 High High
Bioavailability 15 88.92 High High
Clonidine 5 84.88 Quite High
depression 12 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 4 99.08 Very High Very High Very High
Growth Hormone Deficiency 102 98.80 Very High Very High Very High
Thyroid Disease 84 97.68 Very High Very High Very High
Acromegaly 96 97.64 Very High Very High Very High
Metastasis 4 97.56 Very High Very High Very High
Disease 16 95.16 Very High Very High Very High
Pollakiuria 2 94.88 High High
Arthralgia 1 94.60 High High
Pressure And Volume Under Development 3 94.08 High High
Carpal Tunnel Syndrome 1 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By regression analysis, the only factor noted to affect rhGH response was the concurrent use of prednisone.
Regulation (response) of rhGH
1) Confidence 0.30 Published 1993 Journal Kidney Int. Suppl. Section Abstract Doc Link 8246373 Disease Relevance 0.13 Pain Relevance 0.06
Considering the beneficial effects of rhGH replacement in patients with GHD due to other causes than acromegaly, substitution in this particular subgroup is warranted.
Regulation (effects) of rhGH associated with acromegaly and growth hormone deficiency
2) Confidence 0.27 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 1.23 Pain Relevance 0
Body composition did not change during rhGH replacement, whereas it has been consistently found to be altered by rhGH replacement in patients with GHD due to other diseases (an increase in lean body mass and a decrease in body fat [1]).
Neg (not) Regulation (change) of rhGH in body associated with disease and growth hormone deficiency
3) Confidence 0.27 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 0.84 Pain Relevance 0
We did not find many marked beneficial effects of rhGH replacement in these patients.
Neg (not) Regulation (effects) of rhGH
4) Confidence 0.27 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 1.19 Pain Relevance 0
The efficacy of rhGH was evaluated using growth velocity index (GVI) and height standard deviation (Z) score.
Regulation (efficacy) of rhGH
5) Confidence 0.13 Published 1993 Journal Kidney Int. Suppl. Section Abstract Doc Link 8246373 Disease Relevance 0.23 Pain Relevance 0.08
The small uncontrolled studies conducted to date suggest that the most notable effect of rhGH treatment is the reduction of truncal adiposity and buffalo humps and that the agent has little effect on restoring the adiposity of the appendicular muscles, buttocks or face.
Regulation (effect) of rhGH in face
6) Confidence 0.10 Published 2000 Journal BioDrugs Section Abstract Doc Link 18034560 Disease Relevance 1.35 Pain Relevance 0.09
[Marked effectiveness of the LH-RH analogue in a case of prostate cancer with large lymph node metastasis].
Regulation (effectiveness) of LH-RH in lymph node associated with metastasis and reprotox - general 1
7) Confidence 0.06 Published 1994 Journal Hinyokika Kiyo Section Title Doc Link 7942372 Disease Relevance 0.46 Pain Relevance 0.09
[Marked effectiveness of the LH-RH analogue in a case of prostate cancer with large lymph node metastasis].
Regulation (effectiveness) of LH-RH in lymph node associated with metastasis and reprotox - general 1
8) Confidence 0.06 Published 1994 Journal Hinyokika Kiyo Section Title Doc Link 7942372 Disease Relevance 0.46 Pain Relevance 0.09
The relationships between GH secretion and thyroid function, as well as the effects of rhGH administration on thyroid hormone levels have been the subject of numerous studies.
Regulation (effects) of rhGH in thyroid
9) Confidence 0.04 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.07 Pain Relevance 0.04
First reports, concerning the effects of rhGH therapy on thyroid hormone levels in children also confirmed an increase of extrathyroidal conversion of T4 to T3 during the therapy [6].
Regulation (effects) of rhGH in thyroid
10) Confidence 0.04 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.24 Pain Relevance 0
It seems also important to establish - if possible - the threshold values of pre-rhGH-treatment TSH and/or FT4 levels predictive for revealing hypothyroidism during rhGH administration.


Regulation (values) of rhGH associated with thyroid disease
11) Confidence 0.02 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.49 Pain Relevance 0

General Comments

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