INT54840

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Context Info
Confidence 0.73
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.67
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HTR4) plasma membrane (HTR4) cytoplasm (HTR4)
signal transducer activity (HTR4)
Anatomy Link Frequency
enterocytes 2
brain 2
smooth muscles 1
nerves 1
muscle 1
HTR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 21 99.92 Very High Very High Very High
spastic colon 33 98.48 Very High Very High Very High
agonist 10 89.72 High High
abdominal pain 5 87.36 High High
Sumatriptan 2 83.72 Quite High
antagonist 19 70.48 Quite High
tetrodotoxin 1 62.64 Quite High
qutenza 2 61.28 Quite High
headache 1 42.96 Quite Low
nud 3 34.08 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

26 98.48 Very High Very High Very High
Functional Bowel Disorder 8 98.28 Very High Very High Very High
Constipation 8 96.80 Very High Very High Very High
Gastrointestinal Disease 3 88.64 High High
Abdominal Pain 5 87.36 High High
Diarrhoea 11 72.80 Quite High
Flatulence 1 43.92 Quite Low
Headache 1 42.96 Quite Low
Vomiting 1 41.84 Quite Low
Dyspepsia 3 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin induces Cl- secretion in human jejunal mucosa in vitro via a nonneural pathway at a 5-HT4 receptor.
Localization (secretion) of 5-HT4 associated with serotonin
1) Confidence 0.73 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7943231 Disease Relevance 0 Pain Relevance 0.20
In situ hybridization experiments performed in guinea pig confirmed that 5-HT4 receptors are localized on the terminals of the striatopallidal and striatonigral projections. 5-HT7 binding sites were labelled in rat and guinea pig brains by incubating with 3H-5-CT in the presence of 100 microM WAY 100135 and 250 microM GR 127935; the distribution obtained in both species agreed, in general, with that of the corresponding mRNA coding for them.
Localization (localized) of 5-HT4 in brains
2) Confidence 0.73 Published 1996 Journal Histochem. J. Section Abstract Doc Link 8968727 Disease Relevance 0 Pain Relevance 0.17
By using 3H-ketanserin and 3H-mesulergine in parallel with in situ hybridization using the corresponding oligonucleotides, we were able to show that these ligands label respectively 5-HT2A and 5-HT2C binding sites in monkey brain. 5-HT4 receptors were localized in the brain of several species including humans by using 125I-SB 207710.
Localization (localized) of 5-HT4 in brain
3) Confidence 0.73 Published 1996 Journal Histochem. J. Section Abstract Doc Link 8968727 Disease Relevance 0 Pain Relevance 0.18
5-Hydroxytryptamine (5-HT) release and neural reflex pathways activated in response to mucosal stroking were investigated in muscle-stripped human jejunum mounted in modified Ussin</span>g chambers.
Localization (release) of 5-HT4 in muscle
4) Confidence 0.68 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10484375 Disease Relevance 0 Pain Relevance 0.06
The drug's stimulation of 5-HT4 receptors on intestinal enterocytes increases peristaltic activity and fluid secretion into the gut lumen, facilitating stool passage.
Localization (secretion) of 5-HT4 in enterocytes
5) Confidence 0.68 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17253916 Disease Relevance 0.58 Pain Relevance 0.59
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT4 in smooth muscles associated with serotonin
6) Confidence 0.30 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT4 in enterocytes associated with serotonin
7) Confidence 0.10 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74
Serotonin is secreted by enterochromaffin (EC) cells and acts on receptors located on smooth muscles, enterocytes and nerves (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT7).
Localization (secreted) of 5-HT4 in nerves associated with serotonin
8) Confidence 0.10 Published 2007 Journal Wiad. Lek. Section Abstract Doc Link 18175558 Disease Relevance 0.32 Pain Relevance 0.74

General Comments

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