INT54848

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Context Info
Confidence 0.96
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.80
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
cartilage 1
fibroblasts 1
articular cartilage 1
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 10 99.76 Very High Very High Very High
Morphine 10 99.50 Very High Very High Very High
Snapping jaw 7 98.88 Very High Very High Very High
metalloproteinase 12 98.76 Very High Very High Very High
addiction 1 98.52 Very High Very High Very High
Pain 13 97.48 Very High Very High Very High
antagonist 1 94.64 High High
Opioid 1 94.20 High High
narcan 1 93.76 High High
Osteoarthritis 6 90.40 High High
Disease Link Frequency Relevance Heat
Low Back Pain 15 99.76 Very High Very High Very High
Temporomandibular Joint Syndrome 7 98.88 Very High Very High Very High
Opiate Addiction 1 98.80 Very High Very High Very High
Pain 10 97.48 Very High Very High Very High
Hypercalcemia 2 92.80 High High
Osteoarthritis 6 90.40 High High
Osteoporosis 2 85.44 High High
Natriuresis 1 84.96 Quite High
Cv General 3 Under Development 1 84.40 Quite High
Injury 177 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ratios of type II collagen degradation markers to collagen synthesis markers were better than individual biomarkers at differentiating the OA subgroups, e.g., the ratio of [uCTX-II][uC1,2C] to sCPII was associated with a risk of ROA versus no OA of 3.47 (95% CI 1.34-9.03) and a risk of pre-ROA versus no OA of 2.56 (95% CI 1.03-6.40).
Protein_catabolism (degradation) of type
1) Confidence 0.96 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404937 Disease Relevance 0 Pain Relevance 0
Neutral endopeptidase is a mammalian type II integral membrane zinc-containing endopeptidase, which degrades and inactivates a number of bioactive peptides.
Protein_catabolism (degrades) of type
2) Confidence 0.96 Published 2000 Journal J. Mol. Biol. Section Abstract Doc Link 10669592 Disease Relevance 0.23 Pain Relevance 0.27
This project was originally designed to examine the expression of MMPs and the tissue inhibitors of MMPs (TIMPs) by diseased human TMJ synovial fibroblasts and to determine their ability to degrade Type I collagen.
Protein_catabolism (degrade) of Type in fibroblasts associated with snapping jaw and metalloproteinase
3) Confidence 0.96 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15652180 Disease Relevance 0.53 Pain Relevance 0.80
These results suggest that morphine may cause a decrease in degradation of type IV collagen in patients with heroin addiction.
Protein_catabolism (degradation) of type associated with addiction, opiate addiction and morphine
4) Confidence 0.64 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943361 Disease Relevance 0.15 Pain Relevance 1.09
We measured urinary excretion of cartilage-specific collagen type II fragments as a marker of cartilage degradation.
Protein_catabolism (degradation) of type in cartilage
5) Confidence 0.64 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18831886 Disease Relevance 0.61 Pain Relevance 0.68
Type 2 protease-activated receptors (PAR-2) are cleaved by serine-proteases such as trypsin and tryptase.
Protein_catabolism (cleaved) of Type
6) Confidence 0.64 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18482083 Disease Relevance 0 Pain Relevance 0
Matrix metalloproteinase-13 (MMP13) is a Zn(2+)-dependent protease that catalyzes the cleavage of type II collagen, the main structural protein in articular cartilage.
Protein_catabolism (cleavage) of type in articular cartilage associated with metalloproteinase
7) Confidence 0.64 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17623656 Disease Relevance 0.30 Pain Relevance 0.21
Matrix metalloproteinases are members of a family of secreted and membrane-bound enzymes that are capable of degrading highly proteolytic resistant fibrillar type I and III collagens.
Protein_catabolism (degrading) of type associated with metalloproteinase
8) Confidence 0.64 Published 2000 Journal Z Kardiol Section Abstract Doc Link 11098546 Disease Relevance 0.38 Pain Relevance 0.17
The elevation in the ratio TPyr/TDpyr in AS compared to controls indicates that in AS there is a type I-collagen degradation in tissues different from bone.
Protein_catabolism (degradation) of type associated with spinal inflammation
9) Confidence 0.64 Published 1999 Journal Clin. Chim. Acta Section Abstract Doc Link 10556657 Disease Relevance 0.79 Pain Relevance 0.52
Eighty-six (38%) subjects had Modic change at L5-S1; 25 (11%) had type I, 58 (25%) type II, and three subjects had both type I and type II change at L5-S1.
Protein_catabolism (had) of type
10) Confidence 0.12 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2373785 Disease Relevance 0.33 Pain Relevance 0.04
-actin DNA and mRNA without degrading Adenovirus Type 17 DNA.

5'-VVVVVVVVAA-3' Primers Enable Random Multiplex Amplification of Plasmid DNA

Protein_catabolism (degrading) of Type
11) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1950496 Disease Relevance 0 Pain Relevance 0
Prognosis and rate of union are closely related to both the fracture type and degree of displacement.
Protein_catabolism (degree) of type
12) Confidence 0.04 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989526 Disease Relevance 0.49 Pain Relevance 0

General Comments

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