INT5489

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Context Info
Confidence 0.80
First Reported 1986
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 172
Total Number 173
Disease Relevance 39.46
Pain Relevance 33.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
reticulum 14
internal 7
plasma 5
neutrophils 4
MCF-7 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 704 100.00 Very High Very High Very High
Eae 10 100.00 Very High Very High Very High
Nicotine 6 100.00 Very High Very High Very High
agonist 448 99.86 Very High Very High Very High
fluoxetine 23 99.84 Very High Very High Very High
Calcium channel 118 99.74 Very High Very High Very High
conotoxin 34 99.64 Very High Very High Very High
5HT 26 99.60 Very High Very High Very High
lidocaine 17 99.48 Very High Very High Very High
depression 89 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tinnitus 107 99.98 Very High Very High Very High
Congenital Anomalies 24 99.84 Very High Very High Very High
Anaplastic Astrocytoma 11 99.68 Very High Very High Very High
Death 223 99.60 Very High Very High Very High
Depression 92 99.46 Very High Very High Very High
Neuroblastoma 36 99.44 Very High Very High Very High
Apoptosis 316 99.16 Very High Very High Very High
Acute Renal Failure 10 98.84 Very High Very High Very High
Thrombosis Related Under Development 4 98.60 Very High Very High Very High
Infection 152 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Localization (release) of Ca2 in reticulum associated with versed
1) Confidence 0.80 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.16 Pain Relevance 0.27
Results showed that in the control group, E-Ca2+, IF, MCV and F-Hb were gradually increased and Ca2+-Mg2+-ATPase and Na+-K+-ATPase activities were decreased.
Localization (decreased) of Ca2
2) Confidence 0.73 Published 2004 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 15315180 Disease Relevance 0.22 Pain Relevance 0.12
Thus our studies have contributed to basic knowledge of regulation of Ca2+ release function.
Localization (release) of Ca2
3) Confidence 0.71 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9137560 Disease Relevance 0.17 Pain Relevance 0.08
Midazolam attenuates the smooth muscle contraction induced by norepinephrine, acting by an inhibition of Ca2+ influx occurring through voltage-operated Ca2+ channels and through agonist-mediated Ca2+ channels and by an inhibition of Ca2+ release from intracellular storage sites (sarcoplasmic reticulum) [33].
Localization (release) of Ca2 in reticulum associated with versed and agonist
4) Confidence 0.70 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.41 Pain Relevance 0.28
Gating of the cardiac Ca2+ release channel: the role of Na+ current and Na(+)-Ca2+ exchange.
Localization (release) of Ca2
5) Confidence 0.68 Published 1992 Journal Science Section Title Doc Link 1311127 Disease Relevance 0 Pain Relevance 0.24
These results suggest that the NO-induced rebound contraction involves both Ca2+-release from the ryanodine-sensitive store and Ca2+-influx through L-type channels.
Localization (release) of Ca2
6) Confidence 0.68 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12233818 Disease Relevance 0 Pain Relevance 0.09
We have investigated the effects of anesthetic and related agents on Ca(2+)-induced Ca2+ release (CICR) in heavy sarcoplasmic reticulum isolated from rabbit skeletal muscle.
Localization (release) of Ca2 in skeletal muscle
7) Confidence 0.68 Published 1989 Journal J Anesth Section Abstract Doc Link 15236048 Disease Relevance 0.17 Pain Relevance 0.32
The rate of Ca(2+)-induced Ca2+ release (CICR) was normal, suggesting that the mechanism of "MH" observed in our patient with BMD is not the same as that of classical MH.
Localization (release) of Ca2 associated with duchenne muscular dystrophy and malignant hyperthermia
8) Confidence 0.68 Published 1995 Journal Neuromuscul. Disord. Section Abstract Doc Link 7719142 Disease Relevance 1.30 Pain Relevance 0.07
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Localization (release) of Ca2 in reticulum associated with versed
9) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.16 Pain Relevance 0.27
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Localization (decrease) of Ca2 in reticulum associated with versed
10) Confidence 0.65 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.16 Pain Relevance 0.26
In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing.
Localization (release) of Ca2
11) Confidence 0.62 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9137560 Disease Relevance 0.13 Pain Relevance 0
In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing.
Localization (release) of Ca2
12) Confidence 0.62 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9137560 Disease Relevance 0.13 Pain Relevance 0
Ca2+ release test was performed.
Localization (release) of Ca2
13) Confidence 0.62 Published 1991 Journal Masui Section Abstract Doc Link 1875546 Disease Relevance 0.78 Pain Relevance 0.13
Muscarinic receptor-mediated Ca2+ release was also detected in kidney epithelial cells but not in rat fibroblasts, glial cells or differentiated neuroblastoma x glioma hybrid cells.
Localization (release) of Ca2 in epithelial cells associated with neuroblastoma and glioma
14) Confidence 0.62 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2443130 Disease Relevance 0.34 Pain Relevance 0.18
Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells leads to Ca2+ mobilization as measured by quin 2 fluorescence.
Localization (mobilization) of Ca2 in 1321N1 associated with anaplastic astrocytoma
15) Confidence 0.62 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2443130 Disease Relevance 0.17 Pain Relevance 0.15
Suppression of 1,4,5-trisphosphate (IP3) formation by 2 microM U73122 (a phospholipase C inhibitor) did not affect 100 microM fluoxetine-induced Ca2+ release.
Localization (release) of Ca2 associated with fluoxetine
16) Confidence 0.61 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11191831 Disease Relevance 0 Pain Relevance 0.60
In Ca2+-free medium pretreatment with 1 microM thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+ pump, abolished 100 microM fluoxetine-induced Ca2+ release.
Localization (release) of Ca2 in reticulum associated with fluoxetine
17) Confidence 0.61 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11191831 Disease Relevance 0 Pain Relevance 0.59
TMB-8 and ryanodine both partially blocked the increase in [Ca2+]i in the presence of external Ca2+, indicating that Ca2+ release from intracellular pools also occurred after the initial Ca2+ influx.
Localization (release) of Ca2 in external
18) Confidence 0.61 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7519371 Disease Relevance 0 Pain Relevance 0.13
However, the magnitude of the [Ca2+]i increase caused by NaCN was abolished in ionomycin-treated the [Ca2+]i increase caused by NaCN was abolished in ionomycin-treated cells, indicating that intracellular Ca2+ release induced by NaCN is derived from an ionomycin-sensitive Ca2+ pool.
Localization (release) of Ca2
19) Confidence 0.61 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7519371 Disease Relevance 0 Pain Relevance 0.12
CONCLUSIONS: Isoflurane reduction of the carbachol-evoked transient increase in cytoplasmic Ca2+ requires full caffeine-sensitive Ca2+ stores and Ca2+ release from the caffeine-sensitive stores through the ryanodine-sensitive Ca2+ release channels.
Localization (release) of Ca2
20) Confidence 0.61 Published 2003 Journal Anesthesiology Section Body Doc Link 14508321 Disease Relevance 0 Pain Relevance 0

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