INT54897

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.08
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA9) protein folding (HSPA9) mitochondrion (HSPA9)
enzyme binding (HSPA9) cytoplasm (HSPA9)
Anatomy Link Frequency
leukocyte 2
spinal 1
mucosa associated lymphoid tissue 1
HSPA9 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 100.00 Very High Very High Very High
analgesia 2 98.30 Very High Very High Very High
cINOD 10 93.56 High High
Inflammation 6 92.52 High High
Inflammatory response 2 90.56 High High
Analgesic 1 89.80 High High
local anesthetic 1 87.40 High High
carbamazepine 24 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Lamotrigine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Generalized Exanthematous Pustulosis 14 100.00 Very High Very High Very High
Shock 3 100.00 Very High Very High Very High
Marginal Zone B-cell Lymphoma 1 99.52 Very High Very High Very High
Apoptosis 23 99.24 Very High Very High Very High
Bullous Skin Disease 212 98.72 Very High Very High Very High
Alopecia 2 97.80 Very High Very High Very High
Reprotox - General 1 2 95.48 Very High Very High Very High
Nevus 2 93.12 High High
INFLAMMATION 8 92.52 High High
Keloid Scars 4 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This prospective study was designed to evaluate the influence of the subarachnoid position of 28-gauge spinal catheters on the speed of onset of analgesia and on the dose of plain bupivacaine 0.5% required for a block at the level of T-10 in CSA.
Negative_regulation (block) of CSA in spinal associated with anesthesia and analgesia
1) Confidence 0.41 Published 1994 Journal Reg Anesth Section Abstract Doc Link 7947422 Disease Relevance 0 Pain Relevance 0.87
Our data suggest decreases in defense response genes, including the heat-shock protein HSPA9B, CD69, and mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) associated with arsenic exposure.
Negative_regulation (decreases) of HSPA9B in mucosa associated lymphoid tissue associated with marginal zone b-cell lymphoma and shock
2) Confidence 0.30 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.39 Pain Relevance 0.05
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (pustulosis) of CsA in leukocyte associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
3) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.36 Pain Relevance 0.14
AGEP: acute generalized exanthematous pustulosis; CLA: cutaneous leukocyte antigen; CsA: ciclosporine; CTL: cytotoxic T lymphocytes; EM: erythema multiforme; HLA: human leukocyte antigen; IVIG: intravenous immunoglobuline; MHC: major histocompatibility complex; NSAID: non-steroidal anti-inflammatory drug; SJS: Stevens Johnson syndrome; SSSS: staphylococcal scalded skin syndrome; TEN: toxic epidermal necrolysis.


Negative_regulation (ciclosporine) of CsA in leukocyte associated with staphylococcus infection, skin infection, acute generalized exanthematous pustulosis, inflammation, syndrome, cinod and bullous skin disease
4) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 2.33 Pain Relevance 0.14

General Comments

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