INT5490

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 52
Total Number 52
Disease Relevance 9.73
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
smooth muscle 4
neurons 2
vesicle 2
plasma 1
red blood cells 1
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 58 100.00 Very High Very High Very High
imagery 49 100.00 Very High Very High Very High
Ziconotide 8 99.74 Very High Very High Very High
Pain 77 99.36 Very High Very High Very High
Ventral tegmentum 9 99.28 Very High Very High Very High
Migraine 8 99.24 Very High Very High Very High
headache 29 98.40 Very High Very High Very High
Dismenorea 6 97.52 Very High Very High Very High
antagonist 172 96.76 Very High Very High Very High
TRP channel 52 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 78 99.36 Very High Very High Very High
Headache 36 99.24 Very High Very High Very High
Disease 343 98.74 Very High Very High Very High
Tension-type Headache 1 98.72 Very High Very High Very High
Death 102 98.52 Very High Very High Very High
Reprotox - General 1 9 97.52 Very High Very High Very High
Targeted Disruption 41 97.40 Very High Very High Very High
Cardiovascular Disease 8 95.52 Very High Very High Very High
Neuroblastoma 27 95.36 Very High Very High Very High
INFLAMMATION 169 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gating of the cardiac Ca2+ release channel: the role of Na+ current and Na(+)-Ca2+ exchange.
Ca2 Binding (Gating) of
1) Confidence 0.36 Published 1992 Journal Science Section Title Doc Link 1311127 Disease Relevance 0 Pain Relevance 0.24
CP-10 (chemotactic protein of m.w. 10,000) is a member of the S100 superfamily of Ca2+ binding peptides, which has potent chemotactic activity for murine and human myeloid cells.
Ca2 Binding (member) of in myeloid cells
2) Confidence 0.36 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378879 Disease Relevance 0.77 Pain Relevance 0.19
Elevated Ca2+/Mg2+ ratios are also associated with the onset of migraine and tension headaches.[23]
Ca2 Binding (associated) of associated with tension-type headache, migraine and headache
3) Confidence 0.36 Published 2008 Journal Journal of Human Reproductive Sciences Section Body Doc Link PMC2700668 Disease Relevance 0.58 Pain Relevance 0.33
Thus, the specific but completely reversible inhibition by xenon of the G2-M transition and the block at metaphase suggest an interaction with a Ca2+-dependent event involved in the control of these processes.
Ca2 Binding (interaction) of
4) Confidence 0.31 Published 1999 Journal Pflugers Arch. Section Abstract Doc Link 10087152 Disease Relevance 0 Pain Relevance 0.11
Our data strongly suggest, for the first time, the molecular requirements for testosterone binding to L-type Ca2+ channels, thereby supporting its beneficial role as an endogenous Ca2+ channel antagonist in the treatment of cardiovascular disease.
Ca2 Binding (binding) of associated with cardiovascular disease and antagonist
5) Confidence 0.30 Published 2007 Journal Cell Calcium Section Abstract Doc Link 17173968 Disease Relevance 0.26 Pain Relevance 0.13
The missing DNA binding activity of CAR(SV5) is in agreement with the observation that the structural similar mouse CAR2 also did not bind to DNA [15].
CAR2 Neg (not) Binding (bind) of in CAR
6) Confidence 0.27 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
Systemically absorbed dorzolamide binds mainly to CA-II in the red blood cells with plasma protein binding of the drug at 33%.
CA-II Binding (binds) of in red blood cells
7) Confidence 0.26 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.14 Pain Relevance 0.13
Other important interactions are the sorption to organic matter, surface adsorption to mineral constituents, ion exchange, complex formation with metal ions such as Ca2+, Mg2+, Fe3+, or Al3+, and hydrogen bonding (Diaz-Cruz et al. 2003).
Ca2 Binding (formation) of
8) Confidence 0.26 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1314909 Disease Relevance 0 Pain Relevance 0
Preincubation of S100A8/S100A9 in the absence of Ca2+ led to an interaction with flavocytochrome b558 but not to a conformational change, supporting the fact that Ca2+, through S100 binding, is required for NADPH oxidase activity [157].
Ca2 Binding (binding) of
9) Confidence 0.25 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Taken together, this model predicts that in HEK293 cells, the level of cytosolic Ca2+ associated with Echinacea treatment increases through two mechanisms: initially the release of Ca2+ from ER Ca2+ stores, and subsequently Ca2+ influx via SOCE.
Ca2 Binding (associated) of
10) Confidence 0.23 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.15 Pain Relevance 0.04
Thapsigargin and 2-ABP inhibition experiments indicate that Echinacea extract may induce Ca2+ influx by activating SOCE following depletion of Ca2+ from intracellular stores
Ca2 Binding (influx) of
11) Confidence 0.23 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.11
In order for it to be produced, calmodulin must be bound to the enzyme, and it only binds in the presence of Ca2+, which it obtains from the cytoplasmic content [48].
Ca2 Binding (binds) of
12) Confidence 0.23 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0.05 Pain Relevance 0.04
Dorzolamide decreases the secretion of aqueous humor in the ciliary processes by inhibition of carbonic anhydrase II, the most active isoenzyme and found primarily in red blood cells.
carbonic anhydrase II Neg (inhibition) Binding (inhibition) of in red blood cells
13) Confidence 0.17 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693974 Disease Relevance 0.40 Pain Relevance 0.04
The Ca2+/calmodulin complex then activates MLCK, with subsequent phosphorylation of myosin light chain.60) Thus, the more intracellular Ca2+ concentration is increased, the more contraction of vascular smooth muscle will occur.
Ca2 Binding (complex) of in smooth muscle
14) Confidence 0.17 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 0.33 Pain Relevance 0.19
In several animal models of PD, while the majority of A10 neurons (mostly resistant) contain Ca2+- binding proteins, many fewer neurons in A9 (the vulnerable region) contain such Ca2+-buffering proteins (Gerfen et al., 1985; Liang et al., 1996a,b).
Ca2 Binding (binding) of in neurons associated with ventral tegmentum and disease
15) Confidence 0.15 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.63 Pain Relevance 0.13
Their argument was strengthened by experiments where Ca2+ dependence of these A?
Ca2 Binding (experiments) of associated with addiction
16) Confidence 0.11 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.26 Pain Relevance 0.05
Their argument was strengthened by experiments where Ca2+ dependence of these A?
Ca2 Binding (dependence) of associated with addiction
17) Confidence 0.11 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.26 Pain Relevance 0.05
Here, an N-terminal domain is capable of interacting with both the cyclic nucleotide binding region in the C terminus of the protein and Ca2+/CaM.
Ca2 Binding (interacting) of
18) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
DREAM contains four EF-hands, of which three are responsible for binding of Ca2+ ions (1).
Ca2 Binding (binding) of
19) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.19 Pain Relevance 0.14
The S100B increases Ca2+ absorption by buffering Ca2+ in the cytoplasm and increases ATP-dependent Ca2+ transport in duodenal membrane vesicles, involving second messengers, such as cAMP, cGMP, G-proteins, diacylglycerol through a phosphorylation cascade.
Ca2 Binding (absorption) of in vesicles
20) Confidence 0.09 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.08 Pain Relevance 0

General Comments

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