INT54901

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Context Info
Confidence 0.02
First Reported 1993
Last Reported 1994
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FYN) endosome (FYN) plasma membrane (FYN)
Anatomy Link Frequency
dopaminergic neurons 4
FYN (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 5 99.98 Very High Very High Very High
Pain 4 99.60 Very High Very High Very High
Ventral tegmentum 8 98.72 Very High Very High Very High
Morphine 1 94.60 High High
midbrain 4 94.40 High High
analgesia 2 93.32 High High
Chronic pancreatitis 1 91.20 High High
Substantia nigra 3 76.60 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3 98.72 Very High Very High Very High
Cancer 1 93.52 High High
Pain 2 93.08 High High
Pancreatitis 1 91.20 High High
Hyperplasia 2 79.00 Quite High
Metastasis 1 42.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroacupuncture accelerated the expression of c-Fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat.
Positive_regulation (accelerated) of Gene_expression (expression) of protooncogene in dopaminergic neurons associated with ventral tegmentum and electroacupuncture
1) Confidence 0.02 Published 1993 Journal Int. J. Neurosci. Section Title Doc Link 8063541 Disease Relevance 0 Pain Relevance 0.80
On the molecularbiological level, point mutations of the K-ras gene, a mutation or deletion of the p53 suppressor gene and an excess production of the c-erbB-2 protooncogene are found in a great number of pancreatic carcinomas.
Positive_regulation (excess) of Gene_expression (production) of protooncogene associated with pancreatic cancer
2) Confidence 0.02 Published 1994 Journal Zentralbl. Pathol. Section Abstract Doc Link 7947629 Disease Relevance 0.51 Pain Relevance 0.09
Noxious stimulation accelerated the expression of c-fos protooncogene in cholecystokininergic and dopaminergic neurons in the ventral tegmental area.
Positive_regulation (accelerated) of Gene_expression (expression) of protooncogene in dopaminergic neurons associated with pain and ventral tegmentum
3) Confidence 0.01 Published 1993 Journal Peptides Section Title Doc Link 8332552 Disease Relevance 0.09 Pain Relevance 0.65

General Comments

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