INT54911

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 3.27
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neurons 2
plasma 1
MDMs 1
central nervous system 1
dorsal horn 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 100.00 Very High Very High Very High
Neurotransmitter 3 100.00 Very High Very High Very High
Central nervous system 15 99.52 Very High Very High Very High
Glutamate 2 99.24 Very High Very High Very High
chemokine 8 98.70 Very High Very High Very High
Dopamine 18 98.68 Very High Very High Very High
Dorsal horn 1 98.68 Very High Very High Very High
Acupuncture 6 98.60 Very High Very High Very High
headache 3 97.44 Very High Very High Very High
Eae 42 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 14 100.00 Very High Very High Very High
Pancreatic Cancer 2 99.36 Very High Very High Very High
Headache 3 97.44 Very High Very High Very High
Pain 1 92.56 High High
INFLAMMATION 64 91.56 High High
Pituitary Cancer 39 89.40 High High
Stress 115 88.72 High High
Anxiety Disorder 3 85.16 High High
Adenocarcinoma 2 84.08 Quite High
Pancreatitis 4 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombin induced translocation of c-fos and c-jun to the nucleus of MDMs.
Localization (translocation) of c-fos in MDMs
1) Confidence 0.78 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 0.89 Pain Relevance 0.28
Immunohistochemical localisation of the c-fos oncoprotein in pancreatic cancers.
Localization (localisation) of c-fos associated with pancreatic cancer
2) Confidence 0.73 Published 1994 Journal Zentralbl. Pathol. Section Title Doc Link 7947635 Disease Relevance 0.80 Pain Relevance 0.27
In the present work, by studying co-localization of c-Fos immunoreactivity and preproenkephalin and preprodynorphin transcripts, we show that co-administration of the A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 increases the striatal expression of c-fos in GABAergic enkephalinergic but not in GABAergic dynorphinergic neurons.
Localization (co-localization) of c-Fos in CPA associated with gabaergic and agonist
3) Confidence 0.73 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.46
We examined the effects of a 30 min NO-donor infusion on CGRP release in jugular vein blood and c-fos LI within TNC of the rat.
Localization (release) of c-fos in TNC
4) Confidence 0.73 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.10 Pain Relevance 0.51
Sensitization of c-fos immunoreactivity does occur when animals are challenged after 2 days of abstinence (Hedou et al. 2002; Todtenkopf et al. 2002a, b), suggesting a role in the induction or early phases of sensitization.
Localization (Sensitization) of c-fos
5) Confidence 0.73 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.20
For visualization of c-fos, sections were defrosted and fixed in a 4% paraformaldehyde solution in phosphate-buffered saline (PBS; 0.1 M, pH 7.4).
Localization (visualization) of c-fos
6) Confidence 0.73 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry for c-fos
Localization (Immunohistochemistry) of c-fos
7) Confidence 0.73 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2914567 Disease Relevance 0 Pain Relevance 0.04
It is known that c-fos accumulation in nuclei depends on intracellular Ca2+ and second messenger increases as a consequence of changes in neuronal activity (Morgan and Curran, 1988; Sheng and Greenberg, 1990).
Localization (accumulation) of c-fos in neuronal
8) Confidence 0.73 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0.09 Pain Relevance 0.04
The development of diffuse noxious inhibitory controls (DNIC) was studied in postnatal rats aged 12, 21 and 42-days-old, using immunoreactive localization of the c-fos protein products induced in the dorsal horn by noxious stimulation.
Localization (localization) of c-fos in dorsal horn associated with dorsal horn
9) Confidence 0.68 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857953 Disease Relevance 0 Pain Relevance 0.05
Studies suggest that acupuncture and related techniques trigger a sequence of events that include the release of neurotransmitters, endogenous opioid-like substances, and activation of c-fos within the central nervous system.
Localization (release) of c-fos in central nervous system associated with neurotransmitter, endogenous opioid, central nervous system and acupuncture
10) Confidence 0.68 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18227322 Disease Relevance 0.09 Pain Relevance 0.92
Induction of c-fos and lipocortin II were confirmed at the protein level, with c-fos localized to myofiber nuclei and lipocortin II to intramuscular capillaries.
Localization (localized) of c-fos
11) Confidence 0.68 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12937035 Disease Relevance 0.09 Pain Relevance 0.16
The regional, normalized homer1a, arc, zif268, ngfi-b, and c-fos expression measurements were used to calculate Pearson product moment correlations with locomotor activity, plasma corticosterone, and gene expression in other regions within the water and Ensure cues groups.
Localization (normalized) of c-fos in plasma associated with aids-related complex and eae
12) Confidence 0.32 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.05
Notably, three phenomena were observed: (1) co-localization of FOS-ir and AVP-ir or OT-ir; (2) AVP-ir or OT-ir positive while FOS-ir negative; (3) FOS-ir positive while AVP-ir and OT-ir negative.
Localization (localization) of FOS-ir
13) Confidence 0.30 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0.10
However, co-localization of FOS-ir in many AVP and OT neurons was detected in both sides of the SON and PVN following i.c.v. carbachol in the fetal hypothalamus (Figure 5).
Localization (localization) of FOS-ir in hypothalamus
14) Confidence 0.28 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
Although many AVP and OT neurons were co-localized with positive FOS-ir, there were some AVP and OT cells not labeled with FOS-ir.
Localization (localized) of FOS-ir in neurons
15) Confidence 0.26 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570685 Disease Relevance 0 Pain Relevance 0
The potential target genes of miR-145 encode oncogenic proteins, such as myc, kras, fos, yes, fli, cyclin D2, and MAPK transduction proteins [31]. miR-145 targets the insulin receptor substrate-1 (IRS-1) and miR-151-3p targets the insulin receptor substrate-4 (IRS-4), which regulated cell communication, receptor and membrane activities.
Localization (kras) of fos
16) Confidence 0.14 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.29 Pain Relevance 0
Phorbol myristate 13 acetate (PMA) increased the number of fos-LIR cells equally effectively at all stages, but the predominant cellular localization of fos-LIR changed through ontogeny.
Localization (localization) of fos-LIR
17) Confidence 0.12 Published 1995 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8612322 Disease Relevance 0 Pain Relevance 0.49
Phorbol myristate 13 acetate (PMA) increased the number of fos-LIR cells equally effectively at all stages, but the predominant cellular localization of fos-LIR changed through ontogeny.
Localization (localization) of fos-LIR
18) Confidence 0.11 Published 1995 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8612322 Disease Relevance 0 Pain Relevance 0.49
Indeed, as for TNF or other chemokines such as IL-8 and RANTES, MCP-1 depends on the activation of the redox sensitive transcription factors AP-1 and NF-?
Localization (redox) of AP-1 associated with chemokine
19) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.73 Pain Relevance 0.24
In addition, the localization of c-fos gene expression identifies cells that respond to growth factors in vivo.
Localization (localization) of fos
20) Confidence 0.07 Published 1993 Journal Crit Rev Neurobiol Section Abstract Doc Link 8221912 Disease Relevance 0.09 Pain Relevance 0.27

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